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Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.

Medina-Ramírez M, Sanders RW, Sattentau QJ.

Curr Opin HIV AIDS. 2017 May;12(3):241-249. doi: 10.1097/COH.0000000000000363.


Driving HIV-1 into a Vulnerable Corner by Taking Advantage of Viral Adaptation and Evolution.

Harada S, Yoshimura K.

Front Microbiol. 2017 Mar 16;8:390. doi: 10.3389/fmicb.2017.00390. eCollection 2017. Review.


Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality.

Beauparlant D, Rusert P, Magnus C, Kadelka C, Weber J, Uhr T, Zagordi O, Oberle C, Duenas-Decamp MJ, Clapham PR, Metzner KJ, Günthard HF, Trkola A.

PLoS Pathog. 2017 Mar 6;13(3):e1006255. doi: 10.1371/journal.ppat.1006255. eCollection 2017 Mar.


Neuronal Stress and Injury Caused by HIV-1, cART and Drug Abuse: Converging Contributions to HAND.

Sanchez AB, Kaul M.

Brain Sci. 2017 Feb 23;7(3). pii: E25. doi: 10.3390/brainsci7030025. Review.


Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein.

Nguyen HT, Madani N, Ding H, Elder E, Princiotto A, Gu C, Darby P, Alin J, Herschhorn A, Kappes JC, Mao Y, Sodroski JG.

Virol J. 2017 Feb 16;14(1):33. doi: 10.1186/s12985-017-0704-x.


Antigenic characterization of the human immunodeficiency virus (HIV-1) envelope glycoprotein precursor incorporated into nanodiscs.

Witt KC, Castillo-Menendez L, Ding H, Espy N, Zhang S, Kappes JC, Sodroski J.

PLoS One. 2017 Feb 2;12(2):e0170672. doi: 10.1371/journal.pone.0170672. eCollection 2017.


Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells.

Hale M, Mesojednik T, Romano Ibarra GS, Sahni J, Bernard A, Sommer K, Scharenberg AM, Rawlings DJ, Wagner TA.

Mol Ther. 2017 Mar 1;25(3):570-579. doi: 10.1016/j.ymthe.2016.12.023. Epub 2017 Jan 28.


Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors.

Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB 3rd, Sodroski J, Finzi A.

J Virol. 2017 Feb 14;91(5). pii: e02219-16. doi: 10.1128/JVI.02219-16. Print 2017 Mar 1.


Staphylococcus aureus Leukocidin LukED and HIV-1 gp120 Target Different Sequence Determinants on CCR5.

Tam K, Schultz M, Reyes-Robles T, Vanwalscappel B, Horton J, Alonzo F 3rd, Wu B, Landau NR, Torres VJ.

MBio. 2016 Dec 13;7(6). pii: e02024-16. doi: 10.1128/mBio.02024-16.


C-C chemokine receptor type five (CCR5): An emerging target for the control of HIV infection.

Barmania F, Pepper MS.

Appl Transl Genom. 2013 May 26;2:3-16. eCollection 2013 Dec 1. Review.


Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells.

DiGiusto DL, Cannon PM, Holmes MC, Li L, Rao A, Wang J, Lee G, Gregory PD, Kim KA, Hayward SB, Meyer K, Exline C, Lopez E, Henley J, Gonzalez N, Bedell V, Stan R, Zaia JA.

Mol Ther Methods Clin Dev. 2016 Nov 9;3:16067. eCollection 2016.


Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.

Madani N, Princiotto AM, Zhao C, Jahanbakhshsefidi F, Mertens M, Herschhorn A, Melillo B, Smith AB 3rd, Sodroski J.

J Virol. 2017 Jan 18;91(3). pii: e01880-16. doi: 10.1128/JVI.01880-16. Print 2017 Feb 1.


Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc.

Borm K, Jakobsen MR, Cashin K, Flynn JK, Ellenberg P, Ostergaard L, Lee B, Churchill MJ, Roche M, Gorry PR.

Retrovirology. 2016 Nov 3;13(1):74.


Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins.

Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB 3rd, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J.

MBio. 2016 Oct 25;7(5). pii: e01598-16. doi: 10.1128/mBio.01598-16.


A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.

Connell BJ, Chang SY, Prakash E, Yousfi R, Mohan V, Posch W, Wilflingseder D, Moog C, Kodama EN, Clayette P, Lortat-Jacob H.

PLoS One. 2016 Oct 27;11(10):e0165386. doi: 10.1371/journal.pone.0165386. eCollection 2016.


Cytokines and Chemokines in Mycobacterium tuberculosis Infection.

Domingo-Gonzalez R, Prince O, Cooper A, Khader SA.

Microbiol Spectr. 2016 Oct;4(5). doi: 10.1128/microbiolspec.TBTB2-0018-2016.


Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.

Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A, Kiem HP, Rawlings DJ.

Mol Ther Nucleic Acids. 2016 Aug 23;5(8):e352. doi: 10.1038/mtna.2016.56.


The Envelope Cytoplasmic Tail of HIV-1 Subtype C Contributes to Poor Replication Capacity through Low Viral Infectivity and Cell-to-Cell Transmission.

Santos da Silva E, Mulinge M, Lemaire M, Masquelier C, Beraud C, Rybicki A, Servais JY, Iserentant G, Schmit JC, Seguin-Devaux C, Perez Bercoff D.

PLoS One. 2016 Sep 6;11(9):e0161596. doi: 10.1371/journal.pone.0161596. eCollection 2016.


Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.

Liu Z, Huang X, Hu L, Pham L, Poole KM, Tang Y, Mahon BP, Tang W, Li K, Goldfarb NE, Dunn BM, McKenna R, Fanucci GE.

J Biol Chem. 2016 Oct 21;291(43):22741-22756. Epub 2016 Aug 30.


Lineage-Specific Differences between the gp120 Inner Domain Layer 3 of Human Immunodeficiency Virus and That of Simian Immunodeficiency Virus.

Ding S, Medjahed H, Prévost J, Coutu M, Xiang SH, Finzi A.

J Virol. 2016 Oct 28;90(22):10065-10073. Print 2016 Nov 15.

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