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Items: 1 to 20 of 87


Limited proteolysis as a tool to probe the tertiary conformation of dysferlin and structural consequences of patient missense variant L344P.

Woolger N, Bournazos A, Sophocleous RA, Evesson FJ, Lek A, Driemer B, Sutton RB, Cooper ST.

J Biol Chem. 2017 Nov 10;292(45):18577-18591. doi: 10.1074/jbc.M117.790014. Epub 2017 Sep 13.


Structural basis for interdomain communication in SHIP2 providing high phosphatase activity.

Le Coq J, Camacho-Artacho M, Velázquez JV, Santiveri CM, Gallego LH, Campos-Olivas R, Dölker N, Lietha D.

Elife. 2017 Aug 9;6. pii: e26640. doi: 10.7554/eLife.26640.


Phospholipase Cδ1 suppresses cell migration and invasion of breast cancer cells by modulating KIF3A-mediated ERK1/2/β- catenin/MMP7 signalling.

Shao Q, Luo X, Yang D, Wang C, Cheng Q, Xiang T, Ren G.

Oncotarget. 2017 Apr 25;8(17):29056-29066. doi: 10.18632/oncotarget.16072.


Dynamic Response of the C2 Domain of Protein Kinase Cα to Ca2+ Binding.

Morales KA, Yang Y, Cole TR, Igumenova TI.

Biophys J. 2016 Oct 18;111(8):1655-1667. doi: 10.1016/j.bpj.2016.09.008.


Intrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-β Exposes a Gβγ Protein Binding Site.

Kadamur G, Ross EM.

J Biol Chem. 2016 May 20;291(21):11394-406. doi: 10.1074/jbc.M116.723940. Epub 2016 Mar 21.


Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP.

Escoffier J, Lee HC, Yassine S, Zouari R, Martinez G, Karaouzène T, Coutton C, Kherraf ZE, Halouani L, Triki C, Nef S, Thierry-Mieg N, Savinov SN, Fissore R, Ray PF, Arnoult C.

Hum Mol Genet. 2016 Mar 1;25(5):878-91. doi: 10.1093/hmg/ddv617. Epub 2015 Dec 31.


Membrane Repair: Mechanisms and Pathophysiology.

Cooper ST, McNeil PL.

Physiol Rev. 2015 Oct;95(4):1205-40. doi: 10.1152/physrev.00037.2014. Review.


Inositol phosphate pathway controls transcription of telomeric expression sites in trypanosomes.

Cestari I, Stuart K.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2803-12. doi: 10.1073/pnas.1501206112. Epub 2015 May 11.


Phosphoinositide-specific phospholipase C in health and disease.

Cocco L, Follo MY, Manzoli L, Suh PG.

J Lipid Res. 2015 Oct;56(10):1853-60. doi: 10.1194/jlr.R057984. Epub 2015 Mar 27. Review.


Network analysis of circular permutations in multidomain proteins reveals functional linkages for uncharacterized proteins.

Adjeroh D, Jiang Y, Jiang BH, Lin J.

Cancer Inform. 2015 Feb 19;13(Suppl 5):109-24. doi: 10.4137/CIN.S14059. eCollection 2014.


Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes.

Smrcka AV.

J Cardiovasc Pharmacol. 2015 Mar;65(3):203-10. doi: 10.1097/FJC.0000000000000195. Review.


Molecular mechanisms of phospholipase C β3 autoinhibition.

Lyon AM, Begley JA, Manett TD, Tesmer JJ.

Structure. 2014 Dec 2;22(12):1844-54.


Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2.

Xu J, Bacaj T, Zhou A, Tomchick DR, Südhof TC, Rizo J.

Structure. 2014 Feb 4;22(2):269-80. doi: 10.1016/j.str.2013.11.011. Epub 2013 Dec 26.


Ca2+-independent binding of anionic phospholipids by phospholipase C δ1 EF-hand domain.

Cai J, Guo S, Lomasney JW, Roberts MF.

J Biol Chem. 2013 Dec 27;288(52):37277-88. doi: 10.1074/jbc.M113.512186. Epub 2013 Nov 14.


Phosphoinositides: tiny lipids with giant impact on cell regulation.

Balla T.

Physiol Rev. 2013 Jul;93(3):1019-137. doi: 10.1152/physrev.00028.2012. Review.


Structural insights into phospholipase C-β function.

Lyon AM, Tesmer JJ.

Mol Pharmacol. 2013 Oct;84(4):488-500. doi: 10.1124/mol.113.087403. Epub 2013 Jul 23. Review.


The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes.

Shen W, Martinez K, Chuang CC, McIntosh M.

J Nutr. 2013 May;143(5):584-90. doi: 10.3945/jn.112.173161. Epub 2013 Mar 6.


Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain.

Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJ.

Nat Struct Mol Biol. 2013 Mar;20(3):355-62. doi: 10.1038/nsmb.2497. Epub 2013 Feb 3.


Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C.

Wang X, Barrett M, Sondek J, Harden TK, Zhang Q.

Biochemistry. 2012 Jul 3;51(26):5300-6. Epub 2012 Jun 22.

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