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Items: 1 to 20 of 32


Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers.

Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z.

Genes Dev. 2018 Feb 1;32(3-4):244-257. doi: 10.1101/gad.301366.117. Epub 2018 Feb 26.


Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma.

Aguilera KY, Huang H, Du W, Hagopian MM, Wang Z, Hinz S, Hwang TH, Wang H, Fleming JB, Castrillon DH, Ren X, Ding K, Brekken RA.

Mol Cancer Ther. 2017 Nov;16(11):2473-2485. doi: 10.1158/1535-7163.MCT-16-0834. Epub 2017 Sep 1.


Discoidin domain receptor 1 activity drives an aggressive phenotype in bladder cancer.

Xie X, Rui W, He W, Shao Y, Sun F, Zhou W, Wu Y, Zhu Y.

Am J Transl Res. 2017 May 15;9(5):2500-2507. eCollection 2017.


Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.

Wang Z, Zhang Y, Bartual SG, Luo J, Xu T, Du W, Xun Q, Tu Z, Brekken RA, Ren X, Bullock AN, Liang G, Lu X, Ding K.

ACS Med Chem Lett. 2017 Feb 9;8(3):327-332. doi: 10.1021/acsmedchemlett.6b00497. eCollection 2017 Mar 9.


Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma.

Hur H, Ham IH, Lee D, Jin H, Aguilera KY, Oh HJ, Han SU, Kwon JE, Kim YB, Ding K, Brekken RA.

BMC Cancer. 2017 Jan 31;17(1):87. doi: 10.1186/s12885-017-3051-9.


DDR1 promotes E-cadherin stability via inhibition of integrin-β1-Src activation-mediated E-cadherin endocytosis.

Chen HR, Yeh YC, Liu CY, Wu YT, Lo FY, Tang MJ, Wang YK.

Sci Rep. 2016 Nov 8;6:36336. doi: 10.1038/srep36336.


Discoidin Domain Receptors: Potential Actors and Targets in Cancer.

Rammal H, Saby C, Magnien K, Van-Gulick L, Garnotel R, Buache E, El Btaouri H, Jeannesson P, Morjani H.

Front Pharmacol. 2016 Mar 14;7:55. doi: 10.3389/fphar.2016.00055. eCollection 2016. Review. Erratum in: Front Pharmacol. 2016 Sep 30;7:346.


Evaluation of discoidin domain receptor-2 (DDR2) expression level in normal, benign, and malignant human prostate tissues.

Azemikhah M, Ashtiani HA, Aghaei M, Rastegar H.

Res Pharm Sci. 2015 Jul-Aug;10(4):356-63.


Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2) gene in squamous cell lung cancer of Chinese patients.

Miao L, Wang Y, Zhu S, Shi M, Li Y, Ding J, Yang J, Ye Q, Cai H, Zhang D, Liu H, Song Y.

BMC Cancer. 2014 May 24;14:369. doi: 10.1186/1471-2407-14-369.


Discoidin domain receptor functions in physiological and pathological conditions.

Leitinger B.

Int Rev Cell Mol Biol. 2014;310:39-87. doi: 10.1016/B978-0-12-800180-6.00002-5. Review.


Myocardial fibroblast-matrix interactions and potential therapeutic targets.

Goldsmith EC, Bradshaw AD, Zile MR, Spinale FG.

J Mol Cell Cardiol. 2014 May;70:92-9. doi: 10.1016/j.yjmcc.2014.01.008. Epub 2014 Jan 26. Review.


Blood Clotting Factor VIII: From Evolution to Therapy.

Orlova NA, Kovnir SV, Vorobiev II, Gabibov AG, Vorobiev AI.

Acta Naturae. 2013 Apr;5(2):19-39.


Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.

Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R.

J Biol Chem. 2013 Mar 15;288(11):7430-7. doi: 10.1074/jbc.R112.444158. Epub 2013 Jan 18. Review.


Collagen recognition and transmembrane signalling by discoidin domain receptors.

Carafoli F, Hohenester E.

Biochim Biophys Acta. 2013 Oct;1834(10):2187-94. doi: 10.1016/j.bbapap.2012.10.014. Epub 2012 Nov 2. Review.


DDR2 polymorphisms and mRNA expression in lung cancers of Japanese patients.

Sasaki H, Shitara M, Yokota K, Okuda K, Hikosaka Y, Moriyama S, Yano M, Fujii Y.

Oncol Lett. 2012 Jul;4(1):33-37. Epub 2012 Apr 18.


Chemical proteomics: terra incognita for novel drug target profiling.

Huang F, Zhang B, Zhou S, Zhao X, Bian C, Wei Y.

Chin J Cancer. 2012 Nov;31(11):507-18. doi: 10.5732/cjc.011.10377. Epub 2012 May 23. Review.


Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling.

Carafoli F, Mayer MC, Shiraishi K, Pecheva MA, Chan LY, Nan R, Leitinger B, Hohenester E.

Structure. 2012 Apr 4;20(4):688-97. doi: 10.1016/j.str.2012.02.011. Epub 2012 Apr 3.


Discoidin domain receptor 1: isoform expression and potential functions in cirrhotic human liver.

Song S, Shackel NA, Wang XM, Ajami K, McCaughan GW, Gorrell MD.

Am J Pathol. 2011 Mar;178(3):1134-44. doi: 10.1016/j.ajpath.2010.11.068.


DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin.

Yeh YC, Wu CC, Wang YK, Tang MJ.

Mol Biol Cell. 2011 Apr;22(7):940-53. doi: 10.1091/mbc.E10-08-0678. Epub 2011 Feb 2.


Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

Hidalgo-Carcedo C, Hooper S, Chaudhry SI, Williamson P, Harrington K, Leitinger B, Sahai E.

Nat Cell Biol. 2011 Jan;13(1):49-58. doi: 10.1038/ncb2133. Epub 2010 Dec 19.

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