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Items: 17


Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.

Duchez AC, Boudreau LH, Naika GS, Bollinger J, Belleannée C, Cloutier N, Laffont B, Mendoza-Villarroel RE, Lévesque T, Rollet-Labelle E, Rousseau M, Allaeys I, Tremblay JJ, Poubelle PE, Lambeau G, Pouliot M, Provost P, Soulet D, Gelb MH, Boilard E.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3564-73. doi: 10.1073/pnas.1507905112. Erratum in: Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6825. Naika, Gajendra S [added].


Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner.

Tang K, Cai Y, Joshi S, Tovar E, Tucker SC, Maddipati KR, Crissman JD, Repaskey WT, Honn KV.

Mol Cancer. 2015 Jun 3;14:111. doi: 10.1186/s12943-015-0382-5.


Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.

Rai G, Joshi N, Jung JE, Liu Y, Schultz L, Yasgar A, Perry S, Diaz G, Zhang Q, Kenyon V, Jadhav A, Simeonov A, Lo EH, van Leyen K, Maloney DJ, Holman TR.

J Med Chem. 2014 May 22;57(10):4035-48. doi: 10.1021/jm401915r.


The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.

Muñoz-Garcia A, Thomas CP, Keeney DS, Zheng Y, Brash AR.

Biochim Biophys Acta. 2014 Mar;1841(3):401-8. doi: 10.1016/j.bbalip.2013.08.020. Review.


Rationally designed multitarget agents against inflammation and pain.

Hwang SH, Wecksler AT, Wagner K, Hammock BD.

Curr Med Chem. 2013;20(13):1783-99. Review.


Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.

Ikei KN, Yeung J, Apopa PL, Ceja J, Vesci J, Holman TR, Holinstat M.

J Lipid Res. 2012 Dec;53(12):2546-59. doi: 10.1194/jlr.M026385.


Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB 2nd, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR.

J Med Chem. 2011 Aug 11;54(15):5485-97. doi: 10.1021/jm2005089.


Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, Maloney DJ.

J Med Chem. 2010 Oct 28;53(20):7392-404. doi: 10.1021/jm1008852.


Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.

Wecksler AT, Kenyon V, Garcia NK, Deschamps JD, van der Donk WA, Holman TR.

Biochemistry. 2009 Sep 15;48(36):8721-30. doi: 10.1021/bi9009242.


p63 directly induces expression of Alox12, a regulator of epidermal barrier formation.

Kim S, Choi IF, Quante JR, Zhang L, Roop DR, Koster MI.

Exp Dermatol. 2009 Dec;18(12):1016-21. doi: 10.1111/j.1600-0625.2009.00894.x.


Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.

Wecksler AT, Jacquot C, van der Donk WA, Holman TR.

Biochemistry. 2009 Jul 7;48(26):6259-67. doi: 10.1021/bi802332j.


Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation.

Wecksler AT, Kenyon V, Deschamps JD, Holman TR.

Biochemistry. 2008 Jul 15;47(28):7364-75. doi: 10.1021/bi800550n.


Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.

Deschamps JD, Gautschi JT, Whitman S, Johnson TA, Gassner NC, Crews P, Holman TR.

Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.


A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression.

Boeglin WE, Kim RB, Brash AR.

Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6744-9.


Discovery of a second 15S-lipoxygenase in humans.

Brash AR, Boeglin WE, Chang MS.

Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6148-52.


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