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Items: 1 to 20 of 103


PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium.

Pérez-Lara Á, Thapa A, Nyenhuis SB, Nyenhuis DA, Halder P, Tietzel M, Tittmann K, Cafiso DS, Jahn R.

Elife. 2016 Oct 28;5. pii: e15886. doi: 10.7554/eLife.15886.


In silico analysis of calcium binding pocket of perforin like protein 1: insights into the regulation of pore formation.

Garg S, Sharma V, Ramu D, Singh S.

Syst Synth Biol. 2015 Dec;9(Suppl 1):17-21. doi: 10.1007/s11693-015-9166-x. Epub 2015 Apr 8.


Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.

Bacaj T, Wu D, Burré J, Malenka RC, Liu X, Südhof TC.

PLoS Biol. 2015 Oct 5;13(10):e1002267. doi: 10.1371/journal.pbio.1002267. eCollection 2015 Oct.


Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strength.

Park Y, Seo JB, Fraind A, Pérez-Lara A, Yavuz H, Han K, Jung SR, Kattan I, Walla PJ, Choi M, Cafiso DS, Koh DS, Jahn R.

Nat Struct Mol Biol. 2015 Oct;22(10):815-23. doi: 10.1038/nsmb.3097. Epub 2015 Sep 21.


Site-directed Mutagenesis Shows the Significance of Interactions with Phospholipids and the G-protein OsYchF1 for the Physiological Functions of the Rice GTPase-activating Protein 1 (OsGAP1).

Yung YL, Cheung MY, Miao R, Fong YH, Li KP, Yu MH, Chye ML, Wong KB, Lam HM.

J Biol Chem. 2015 Sep 25;290(39):23984-96. doi: 10.1074/jbc.M115.655639. Epub 2015 Aug 18.


Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.

Zhou Q, Lai Y, Bacaj T, Zhao M, Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Sauter NK, Cohen AE, Soltis SM, Alonso-Mori R, Chollet M, Lemke HT, Pfuetzner RA, Choi UB, Weis WI, Diao J, Südhof TC, Brunger AT.

Nature. 2015 Sep 3;525(7567):62-7. doi: 10.1038/nature14975. Epub 2015 Aug 17.


Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering.

Idevall-Hagren O, Lü A, Xie B, De Camilli P.

EMBO J. 2015 Sep 2;34(17):2291-305. doi: 10.15252/embj.201591565. Epub 2015 Jul 22.


Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle.

Cheng Y, Wang J, Wang Y, Ding M.

Elife. 2015 Feb 24;4. doi: 10.7554/eLife.05118.


Synaptotagmin's role in neurotransmitter release likely involves Ca(2+)-induced conformational transition.

Wu Z, Schulten K.

Biophys J. 2014 Sep 2;107(5):1156-66. doi: 10.1016/j.bpj.2014.07.041.


Synaptotagmin 1 and Ca2+ drive trans SNARE zippering.

Lai Y, Lou X, Wang C, Xia T, Tong J.

Sci Rep. 2014 Apr 3;4:4575. doi: 10.1038/srep04575.


Dissecting the molecular mechanism underlying the intimate relationship between cellulose microfibrils and cortical microtubules.

Lei L, Li S, Bashline L, Gu Y.

Front Plant Sci. 2014 Mar 13;5:90. doi: 10.3389/fpls.2014.00090. eCollection 2014. Review.


Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2.

Xu J, Bacaj T, Zhou A, Tomchick DR, Südhof TC, Rizo J.

Structure. 2014 Feb 4;22(2):269-80. doi: 10.1016/j.str.2013.11.011. Epub 2013 Dec 26.


Neurotransmitter release: the last millisecond in the life of a synaptic vesicle.

Südhof TC.

Neuron. 2013 Oct 30;80(3):675-90. doi: 10.1016/j.neuron.2013.10.022. Review.


Richard Scheller and Thomas Südhof receive the 2013 Albert Lasker Basic Medical Research Award.

Hurst JH.

J Clin Invest. 2013 Oct;123(10):4095-101. doi: 10.1172/JCI72681. Epub 2013 Sep 9. No abstract available.


Differential roles for snapin and synaptotagmin in the synaptic vesicle cycle.

Yu SC, Klosterman SM, Martin AA, Gracheva EO, Richmond JE.

PLoS One. 2013;8(2):e57842. doi: 10.1371/journal.pone.0057842. Epub 2013 Feb 28.


Ancient complexity, opisthokont plasticity, and discovery of the 11th subfamily of Arf GAP proteins.

Schlacht A, Mowbrey K, Elias M, Kahn RA, Dacks JB.

Traffic. 2013 Jun;14(6):636-49. doi: 10.1111/tra.12063. Epub 2013 Mar 20.


Protein-protein and protein-membrane associations in the lignin pathway.

Bassard JE, Richert L, Geerinck J, Renault H, Duval F, Ullmann P, Schmitt M, Meyer E, Mutterer J, Boerjan W, De Jaeger G, Mely Y, Goossens A, Werck-Reichhart D.

Plant Cell. 2012 Nov;24(11):4465-82. doi: 10.1105/tpc.112.102566. Epub 2012 Nov 21.


Controlling synaptotagmin activity by electrostatic screening.

Park Y, Hernandez JM, van den Bogaart G, Ahmed S, Holt M, Riedel D, Jahn R.

Nat Struct Mol Biol. 2012 Oct;19(10):991-7. doi: 10.1038/nsmb.2375. Epub 2012 Sep 2.


Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold.

van den Bogaart G, Meyenberg K, Diederichsen U, Jahn R.

J Biol Chem. 2012 May 11;287(20):16447-53. doi: 10.1074/jbc.M112.343418. Epub 2012 Mar 23.


Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity.

Al-Tawashi A, Jung SY, Liu D, Su B, Qin J.

J Biol Chem. 2012 Apr 27;287(18):14644-58. doi: 10.1074/jbc.M111.261875. Epub 2012 Feb 28.

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