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Items: 1 to 20 of 89

1.

Structural characterization of nonactive site, TrkA-selective kinase inhibitors.

Su HP, Rickert K, Burlein C, Narayan K, Bukhtiyarova M, Hurzy DM, Stump CA, Zhang X, Reid J, Krasowska-Zoladek A, Tummala S, Shipman JM, Kornienko M, Lemaire PA, Krosky D, Heller A, Achab A, Chamberlin C, Saradjian P, Sauvagnat B, Yang X, Ziebell MR, Nickbarg E, Sanders JM, Bilodeau MT, Carroll SS, Lumb KJ, Soisson SM, Henze DA, Cooke AJ.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E297-E306. doi: 10.1073/pnas.1611577114.

PMID:
28039433
2.

Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion.

Houtz J, Borden P, Ceasrine A, Minichiello L, Kuruvilla R.

Dev Cell. 2016 Nov 7;39(3):329-345. doi: 10.1016/j.devcel.2016.10.003.

PMID:
27825441
3.

An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101.

Doebele RC, Davis LE, Vaishnavi A, Le AT, Estrada-Bernal A, Keysar S, Jimeno A, Varella-Garcia M, Aisner DL, Li Y, Stephens PJ, Morosini D, Tuch BB, Fernandes M, Nanda N, Low JA.

Cancer Discov. 2015 Oct;5(10):1049-57. doi: 10.1158/2159-8290.CD-15-0443.

4.

Amelioration of Auditory Response by DA9801 in Diabetic Mouse.

Lee YR, Hong BN, Her YR, Castañeda R, Moon HW, Kang TH.

Evid Based Complement Alternat Med. 2015;2015:230747. doi: 10.1155/2015/230747.

5.

Biogenesis and function of the NGF/TrkA signaling endosome.

Marlin MC, Li G.

Int Rev Cell Mol Biol. 2015;314:239-57. doi: 10.1016/bs.ircmb.2014.10.002. Review.

6.

TRKing down an old oncogene in a new era of targeted therapy.

Vaishnavi A, Le AT, Doebele RC.

Cancer Discov. 2015 Jan;5(1):25-34. doi: 10.1158/2159-8290.CD-14-0765. Review.

7.

Involvement of the Na+/Ca2+ exchanger isoform 1 (NCX1) in neuronal growth factor (NGF)-induced neuronal differentiation through Ca2+-dependent Akt phosphorylation.

Secondo A, Esposito A, Sirabella R, Boscia F, Pannaccione A, Molinaro P, Cantile M, Ciccone R, Sisalli MJ, Scorziello A, Di Renzo G, Annunziato L.

J Biol Chem. 2015 Jan 16;290(3):1319-31. doi: 10.1074/jbc.M114.555516.

8.

Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3β (GSK3β) pathway.

Kim MS, Shutov LP, Gnanasekaran A, Lin Z, Rysted JE, Ulrich JD, Usachev YM.

J Biol Chem. 2014 Nov 7;289(45):31349-60. doi: 10.1074/jbc.M114.587188.

9.

Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.

Uren RT, Turnley AM.

Front Mol Neurosci. 2014 May 14;7:39. doi: 10.3389/fnmol.2014.00039. Review.

10.

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.

Vaishnavi A, Capelletti M, Le AT, Kako S, Butaney M, Ercan D, Mahale S, Davies KD, Aisner DL, Pilling AB, Berge EM, Kim J, Sasaki H, Park SI, Kryukov G, Garraway LA, Hammerman PS, Haas J, Andrews SW, Lipson D, Stephens PJ, Miller VA, Varella-Garcia M, Jänne PA, Doebele RC.

Nat Med. 2013 Nov;19(11):1469-72. doi: 10.1038/nm.3352.

11.

A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation.

Ambjørn M, Dubreuil V, Miozzo F, Nigon F, Møller B, Issazadeh-Navikas S, Berg J, Lees M, Sap J.

PLoS One. 2013 Jun 13;8(6):e65371. doi: 10.1371/journal.pone.0065371.

12.

Dissecting the roles of tyrosines 490 and 785 of TrkA protein in the induction of downstream protein phosphorylation using chimeric receptors.

Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA.

J Biol Chem. 2013 Jun 7;288(23):16606-18. doi: 10.1074/jbc.M113.475285.

13.

Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole.

Ishima T, Iyo M, Hashimoto K.

Transl Psychiatry. 2012 Oct 16;2:e170. doi: 10.1038/tp.2012.97.

14.

The induction of serine/threonine protein phosphorylations by a PDGFR/TrkA chimera in stably transfected PC12 cells.

Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA.

Mol Cell Proteomics. 2012 May;11(5):15-30. doi: 10.1074/mcp.M111.013375.

15.

Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival.

Harrington AW, St Hillaire C, Zweifel LS, Glebova NO, Philippidou P, Halegoua S, Ginty DD.

Cell. 2011 Aug 5;146(3):421-34. doi: 10.1016/j.cell.2011.07.008.

16.

Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol.

Hashimoto K, Ishima T.

PLoS One. 2011 Mar 1;6(3):e17431. doi: 10.1371/journal.pone.0017431.

17.

A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI.

Hashimoto K, Ishima T.

PLoS One. 2010 Nov 8;5(11):e15430. doi: 10.1371/journal.pone.0015430. Erratum in: PLoS One. 2010;5(12) Doi: 10.1371/annotation/afc0a9a2-01c0-4e58-8d69-e0ed4ff953fa.

18.
19.

Vav3-deficient mice exhibit a transient delay in cerebellar development.

Quevedo C, Sauzeau V, Menacho-Márquez M, Castro-Castro A, Bustelo XR.

Mol Biol Cell. 2010 Mar 15;21(6):1125-39. doi: 10.1091/mbc.E09-04-0292.

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