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Aflibercept exhibits VEGF binding stoichiometry distinct from bevacizumab and does not support formation of immune-like complexes.

MacDonald DA, Martin J, Muthusamy KK, Luo JK, Pyles E, Rafique A, Huang T, Potocky T, Liu Y, Cao J, Bono F, Delesque N, Savi P, Francis J, Amirkhosravi A, Meyer T, Romano C, Glinka M, Yancopoulos GD, Stahl N, Wiegand SJ, Papadopoulos N.

Angiogenesis. 2016 Jul;19(3):389-406. doi: 10.1007/s10456-016-9515-8. Epub 2016 May 27.


Maternal diabetes impairs oxidative and inflammatory response in murine placenta.

Saad MI, Abdelkhalek TM, Saleh MM, Haiba MM, Tawfik SH, Kamel MA.

Springerplus. 2016 Apr 26;5:532. doi: 10.1186/s40064-016-2180-y. eCollection 2016.


Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6β: implications for the pathophysiology of human pregnancy complications.

Mizuuchi M, Cindrova-Davies T, Olovsson M, Charnock-Jones DS, Burton GJ, Yung HW.

J Pathol. 2016 Mar;238(4):550-61. doi: 10.1002/path.4678. Epub 2016 Jan 12.


New insights into molecular mechanisms of diabetic kidney disease.

Badal SS, Danesh FR.

Am J Kidney Dis. 2014 Feb;63(2 Suppl 2):S63-83. doi: 10.1053/j.ajkd.2013.10.047. Review.


Flt-1 in colorectal cancer cells is required for the tumor invasive effect of placental growth factor through a p38-MMP9 pathway.

Wei SC, Tsao PN, Weng MT, Cao Z, Wong JM.

J Biomed Sci. 2013 Jun 21;20:39. doi: 10.1186/1423-0127-20-39.


Proteolytic processing regulates placental growth factor activities.

Hoffmann DC, Willenborg S, Koch M, Zwolanek D, Müller S, Becker AK, Metzger S, Ehrbar M, Kurschat P, Hellmich M, Hubbell JA, Eming SA.

J Biol Chem. 2013 Jun 21;288(25):17976-89. doi: 10.1074/jbc.M113.451831. Epub 2013 May 3.


PlGF: a multitasking cytokine with disease-restricted activity.

Dewerchin M, Carmeliet P.

Cold Spring Harb Perspect Med. 2012 Aug 1;2(8). pii: a011056. doi: 10.1101/cshperspect.a011056. Review.


Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis.

Matsubara H, Hogan DE, Morgan EF, Mortlock DP, Einhorn TA, Gerstenfeld LC.

Bone. 2012 Jul;51(1):168-80. doi: 10.1016/j.bone.2012.02.017. Epub 2012 Feb 25.


Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab.

Papadopoulos N, Martin J, Ruan Q, Rafique A, Rosconi MP, Shi E, Pyles EA, Yancopoulos GD, Stahl N, Wiegand SJ.

Angiogenesis. 2012 Jun;15(2):171-85. doi: 10.1007/s10456-011-9249-6. No abstract available.


The discovery of placenta growth factor and its biological activity.

De Falco S.

Exp Mol Med. 2012 Jan 31;44(1):1-9. doi: 10.3858/emm.2012.44.1.025. Review.


Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model.

Binsalamah ZM, Paul A, Khan AA, Prakash S, Shum-Tim D.

Int J Nanomedicine. 2011;6:2667-78. doi: 10.2147/IJN.S25175. Epub 2011 Oct 31.


Tying the knot: the cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines.

Iyer S, Acharya KR.

FEBS J. 2011 Nov;278(22):4304-22. doi: 10.1111/j.1742-4658.2011.08350.x. Epub 2011 Oct 7. Review.


Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease.

Patel N, Gonsalves CS, Yang M, Malik P, Kalra VK.

Blood. 2009 Jan 29;113(5):1129-38. doi: 10.1182/blood-2008-07-169821. Epub 2008 Oct 22.


Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha.

Patel N, Gonsalves CS, Malik P, Kalra VK.

Blood. 2008 Aug 1;112(3):856-65. doi: 10.1182/blood-2007-12-130567. Epub 2008 Apr 14.


Vascular endothelial growth factor and placenta growth factor in intrauterine growth-restricted fetuses and neonates.

Malamitsi-Puchner A, Boutsikou T, Economou E, Sarandakou A, Makrakis E, Hassiakos D, Creatsas G.

Mediators Inflamm. 2005 Oct 24;2005(5):293-7.


Placenta growth factor expression is correlated with survival of patients with colorectal cancer.

Wei SC, Tsao PN, Yu SC, Shun CT, Tsai-Wu JJ, Wu CH, Su YN, Hsieh FJ, Wong JM.

Gut. 2005 May;54(5):666-72.


The relationship between transplacental O2 diffusion and placental expression of PlGF, VEGF and their receptors in a placental insufficiency model of fetal growth restriction.

Regnault TR, de Vrijer B, Galan HL, Davidsen ML, Trembler KA, Battaglia FC, Wilkening RB, Anthony RV.

J Physiol. 2003 Jul 15;550(Pt 2):641-56. Epub 2003 May 9.


Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide.

Bussolati B, Dunk C, Grohman M, Kontos CD, Mason J, Ahmed A.

Am J Pathol. 2001 Sep;159(3):993-1008.

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