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Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1.

Datta D, Anbarasu K, Rajabather S, Priya RS, Desai P, Mahalingam S.

J Biol Chem. 2015 Aug 28;290(35):21536-52. doi: 10.1074/jbc.M115.637280. Epub 2015 Jul 9.


The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes.

Paternot S, Colleoni B, Bisteau X, Roger PP.

Cell Cycle. 2014;13(18):2879-88. doi: 10.4161/15384101.2014.946841.


TSC2 epigenetic defect in primary LAM cells. Evidence of an anchorage-independent survival.

Lesma E, Ancona S, Sirchia SM, Orpianesi E, Grande V, Colapietro P, Chiaramonte E, Di Giulio AM, Gorio A.

J Cell Mol Med. 2014 May;18(5):766-79. doi: 10.1111/jcmm.12237. Epub 2014 Mar 7.


Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors.

Cerqueira A, Martín A, Symonds CE, Odajima J, Dubus P, Barbacid M, Santamaría D.

Mol Cell Biol. 2014 Apr;34(8):1452-9. doi: 10.1128/MCB.01163-13. Epub 2014 Feb 10.


The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations.

Bisteau X, Caldez MJ, Kaldis P.

Cancers (Basel). 2014 Jan 13;6(1):79-111. doi: 10.3390/cancers6010079.


CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.

Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, Declercq W, Hengst L, Roger PP.

PLoS Genet. 2013 May;9(5):e1003546. doi: 10.1371/journal.pgen.1003546. Epub 2013 May 30.


The CDK Network: Linking Cycles of Cell Division and Gene Expression.

Fisher RP.

Genes Cancer. 2012 Nov;3(11-12):731-8. doi: 10.1177/1947601912473308.


CDK4: A Key Player in the Cell Cycle, Development, and Cancer.

Baker SJ, Reddy EP.

Genes Cancer. 2012 Nov;3(11-12):658-69. doi: 10.1177/1947601913478972.


Incomplete folding upon binding mediates Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein.

Ou L, Ferreira AM, Otieno S, Xiao L, Bashford D, Kriwacki RW.

J Biol Chem. 2011 Aug 26;286(34):30142-51. doi: 10.1074/jbc.M111.244095. Epub 2011 Jun 29.


PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b.

Meng H, Tian L, Zhou J, Li Z, Jiao X, Li WW, Plomann M, Xu Z, Lisanti MP, Wang C, Pestell RG.

Cell Cycle. 2011 Jan 1;10(1):73-81. Epub 2011 Jan 1.


Alternative cyclin D1 splice forms differentially regulate the DNA damage response.

Li Z, Jiao X, Wang C, Shirley LA, Elsaleh H, Dahl O, Wang M, Soutoglou E, Knudsen ES, Pestell RG.

Cancer Res. 2010 Nov 1;70(21):8802-11. doi: 10.1158/0008-5472.CAN-10-0312. Epub 2010 Oct 12.


Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178.

Gomes FC, Ali NO, Brown E, Walker RG, Grant KM, Mottram JC.

Mol Biochem Parasitol. 2010 Jun;171(2):89-96. doi: 10.1016/j.molbiopara.2010.03.002. Epub 2010 Mar 23.


Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation.

Alfieri R, Barberis M, Chiaradonna F, Gaglio D, Milanesi L, Vanoni M, Klipp E, Alberghina L.

BMC Bioinformatics. 2009 Oct 15;10 Suppl 12:S16. doi: 10.1186/1471-2105-10-S12-S16.


Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.

Bockstaele L, Bisteau X, Paternot S, Roger PP.

Mol Cell Biol. 2009 Aug;29(15):4188-200. doi: 10.1128/MCB.01823-08. Epub 2009 Jun 1.


Crystal structure of human CDK4 in complex with a D-type cyclin.

Day PJ, Cleasby A, Tickle IJ, O'Reilly M, Coyle JE, Holding FP, McMenamin RL, Yon J, Chopra R, Lengauer C, Jhoti H.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4166-70. doi: 10.1073/pnas.0809645106. Epub 2009 Feb 23.


The structure of CDK4/cyclin D3 has implications for models of CDK activation.

Takaki T, Echalier A, Brown NR, Hunt T, Endicott JA, Noble ME.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4171-6. doi: 10.1073/pnas.0809674106. Epub 2009 Feb 23.


p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.

Ray A, James MK, Larochelle S, Fisher RP, Blain SW.

Mol Cell Biol. 2009 Feb;29(4):986-99. doi: 10.1128/MCB.00898-08. Epub 2008 Dec 15.


G0S2 is an all-trans-retinoic acid target gene.

Kitareewan S, Blumen S, Sekula D, Bissonnette RP, Lamph WW, Cui Q, Gallagher R, Dmitrovsky E.

Int J Oncol. 2008 Aug;33(2):397-404.


P21 and p27: roles in carcinogenesis and drug resistance.

Abukhdeir AM, Park BH.

Expert Rev Mol Med. 2008 Jul 1;10:e19. doi: 10.1017/S1462399408000744. Review.

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