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Molecular Probing of the HPV-16 E6 Protein Alpha Helix Binding Groove with Small Molecule Inhibitors.

Rietz A, Petrov DP, Bartolowits M, DeSmet M, Davisson VJ, Androphy EJ.

PLoS One. 2016 Feb 25;11(2):e0149845. doi: 10.1371/journal.pone.0149845. eCollection 2016.


Viral Mimicry to Usurp Ubiquitin and SUMO Host Pathways.

Wimmer P, Schreiner S.

Viruses. 2015 Aug 28;7(9):4854-72. doi: 10.3390/v7092849. Review.


Network Cluster Analysis of Protein-Protein Interaction Network-Identified Biomarker for Type 2 Diabetes.

Li Z, Qiao Z, Zheng W, Ma W.

Diabetes Technol Ther. 2015 Jul;17(7):475-81. doi: 10.1089/dia.2014.0204. Epub 2015 Apr 16.


E2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex.

Coey CT, Fitzgerald ME, Maiti A, Reiter KH, Guzzo CM, Matunis MJ, Drohat AC.

J Biol Chem. 2014 May 30;289(22):15810-9. doi: 10.1074/jbc.M114.572081. Epub 2014 Apr 21.


PEX5 and ubiquitin dynamics on mammalian peroxisome membranes.

Brown AI, Kim PK, Rutenberg AD.

PLoS Comput Biol. 2014 Jan;10(1):e1003426. doi: 10.1371/journal.pcbi.1003426. Epub 2014 Jan 16.


Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 function.

Cherry JJ, Rietz A, Malinkevich A, Liu Y, Xie M, Bartolowits M, Davisson VJ, Baleja JD, Androphy EJ.

PLoS One. 2013 Dec 23;8(12):e84506. doi: 10.1371/journal.pone.0084506. eCollection 2013.


The active form of E6-associated protein (E6AP)/UBE3A ubiquitin ligase is an oligomer.

Ronchi VP, Klein JM, Edwards DJ, Haas AL.

J Biol Chem. 2014 Jan 10;289(2):1033-48. doi: 10.1074/jbc.M113.517805. Epub 2013 Nov 22.


Potential biomarkers for adult acute myeloid leukemia minimal residual disease assessment searched by serum peptidome profiling.

Bai J, He A, Zhang W, Huang C, Yang J, Yang Y, Wang J, Zhang Y.

Proteome Sci. 2013 Aug 3;11:39. doi: 10.1186/1477-5956-11-39. eCollection 2013.


E6AP/UBE3A ubiquitin ligase harbors two E2~ubiquitin binding sites.

Ronchi VP, Klein JM, Haas AL.

J Biol Chem. 2013 Apr 12;288(15):10349-60. doi: 10.1074/jbc.M113.458059. Epub 2013 Feb 25.


Peptide interactions stabilize and restructure human papillomavirus type 16 E6 to interact with p53.

Ansari T, Brimer N, Vande Pol SB.

J Virol. 2012 Oct;86(20):11386-91. Epub 2012 Aug 15.


Crucial role of TSC-22 in preventing the proteasomal degradation of p53 in cervical cancer.

Yoon CH, Rho SB, Kim ST, Kho S, Park J, Jang IS, Woo S, Kim SS, Lee JH, Lee SH.

PLoS One. 2012;7(8):e42006. doi: 10.1371/journal.pone.0042006. Epub 2012 Aug 1.


Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity.

Maezawa S, Fukushima R, Matsushita T, Kato T, Takagaki Y, Nishiyama Y, Ando S, Matsumoto T, Kouda K, Hayano T, Suzuki M, Koiwai K, Koiwai O.

PLoS One. 2012;7(7):e39511. doi: 10.1371/journal.pone.0039511. Epub 2012 Jul 11.


Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling.

Brimer N, Lyons C, Wallberg AE, Vande Pol SB.

Oncogene. 2012 Oct 25;31(43):4639-46. doi: 10.1038/onc.2011.589. Epub 2012 Jan 16.


Ubiquitination of substrates by esterification.

Wang X, Herr RA, Hansen TH.

Traffic. 2012 Jan;13(1):19-24. doi: 10.1111/j.1600-0854.2011.01269.x. Epub 2011 Sep 13. Review.


JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress.

Liu J, Chung HJ, Vogt M, Jin Y, Malide D, He L, Dundr M, Levens D.

EMBO J. 2011 Mar 2;30(5):846-58. doi: 10.1038/emboj.2011.11. Epub 2011 Feb 1.


E3 ubiquitin protein ligase, E6-associated protein (E6-AP) regulates PI3K-Akt signaling and prostate cell growth.

Srinivasan S, Nawaz Z.

Biochim Biophys Acta. 2011 Feb;1809(2):119-27. doi: 10.1016/j.bbagrm.2010.08.011. Epub 2010 Sep 6.


Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3.

Baldwin A, Grueneberg DA, Hellner K, Sawyer J, Grace M, Li W, Harlow E, Munger K.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12463-8. doi: 10.1073/pnas.1007462107. Epub 2010 Jun 28.


SAMPLEX: automatic mapping of perturbed and unperturbed regions of proteins and complexes.

Krzeminski M, Loth K, Boelens R, Bonvin AM.

BMC Bioinformatics. 2010 Jan 26;11:51. doi: 10.1186/1471-2105-11-51.


Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates.

Wang X, Herr RA, Rabelink M, Hoeben RC, Wiertz EJ, Hansen TH.

J Cell Biol. 2009 Nov 30;187(5):655-68. doi: 10.1083/jcb.200908036.


Determinants of stability for the E6 protein of papillomavirus type 16.

Liu Y, Cherry JJ, Dineen JV, Androphy EJ, Baleja JD.

J Mol Biol. 2009 Mar 6;386(4):1123-37.

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