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Items: 1 to 20 of 51


A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.

Wang Y, Lichter-Konecki U, Anyane-Yeboa K, Shaw JE, Lu JT, Östlund C, Shin JY, Clark LN, Gundersen GG, Nagy PL, Worman HJ.

J Cell Sci. 2016 May 15;129(10):1975-80. doi: 10.1242/jcs.187302. Epub 2016 Mar 31.


Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders.

Casasola A, Scalzo D, Nandakumar V, Halow J, Recillas-Targa F, Groudine M, Rincón-Arano H.

Nucleus. 2016;7(1):84-102. doi: 10.1080/19491034.2016.1150397.


Mutant lamin A links prophase to a p53 independent senescence program.

Moiseeva O, Lessard F, Acevedo-Aquino M, Vernier M, Tsantrizos YS, Ferbeyre G.

Cell Cycle. 2015 Aug 3;14(15):2408-21. doi: 10.1080/15384101.2015.1053671. Epub 2015 Jun 1.


An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin.

Jung HJ, Tatar A, Tu Y, Nobumori C, Yang SH, Goulbourne CN, Herrmann H, Fong LG, Young SG.

Mol Cell Biol. 2014 Dec;34(24):4534-44. doi: 10.1128/MCB.00997-14. Epub 2014 Oct 13.


Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum.

Li X, Roberti R, Blobel G.

Nature. 2015 Jan 1;517(7532):104-7. doi: 10.1038/nature13797. Epub 2014 Oct 12.


Porcine LMNA Is a Positional Candidate Gene Associated with Growth and Fat Deposition.

Choi BH, Lee JS, Lee SH, Kim SC, Kim SW, Kim KS, Lee JH, Seong HH, Kim TH.

Asian-Australas J Anim Sci. 2012 Dec;25(12):1649-59. doi: 10.5713/ajas.2012.12288.


Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting.

Wu D, Flannery AR, Cai H, Ko E, Cao K.

Nucleus. 2014 Jan-Feb;5(1):66-74. doi: 10.4161/nucl.28068. Epub 2014 Feb 4.


Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association.

Kalinowski A, Qin Z, Coffey K, Kodali R, Buehler MJ, Lösche M, Dahl KN.

Biophys J. 2013 May 21;104(10):2246-53. doi: 10.1016/j.bpj.2013.04.016.


Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration.

Jung HJ, Nobumori C, Goulbourne CN, Tu Y, Lee JM, Tatar A, Wu D, Yoshinaga Y, de Jong PJ, Coffinier C, Fong LG, Young SG.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1923-32. doi: 10.1073/pnas.1303916110. Epub 2013 May 6.


When lamins go bad: nuclear structure and disease.

Schreiber KH, Kennedy BK.

Cell. 2013 Mar 14;152(6):1365-75. doi: 10.1016/j.cell.2013.02.015. Review.


Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors.

Adam SA, Butin-Israeli V, Cleland MM, Shimi T, Goldman RD.

Nucleus. 2013 Mar-Apr;4(2):142-50. doi: 10.4161/nucl.24089. Epub 2013 Mar 1.


Nuclear lamins in the brain - new insights into function and regulation.

Jung HJ, Lee JM, Yang SH, Young SG, Fong LG.

Mol Neurobiol. 2013 Feb;47(1):290-301. doi: 10.1007/s12035-012-8350-1. Epub 2012 Oct 14. Review.


Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24.

Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG.

J Lipid Res. 2012 Jun;53(6):1176-82. doi: 10.1194/jlr.M026161. Epub 2012 Mar 23.


Understanding the roles of nuclear A- and B-type lamins in brain development.

Young SG, Jung HJ, Coffinier C, Fong LG.

J Biol Chem. 2012 May 11;287(20):16103-10. doi: 10.1074/jbc.R112.354407. Epub 2012 Mar 13. Review.


Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24.

Barrowman J, Hamblet C, Kane MS, Michaelis S.

PLoS One. 2012;7(2):e32120. doi: 10.1371/journal.pone.0032120. Epub 2012 Feb 15.


Lamin A, farnesylation and aging.

Reddy S, Comai L.

Exp Cell Res. 2012 Jan 1;318(1):1-7. doi: 10.1016/j.yexcr.2011.08.009. Epub 2011 Aug 16. Review.


Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells.

Mehta IS, Eskiw CH, Arican HD, Kill IR, Bridger JM.

Genome Biol. 2011 Aug 12;12(8):R74. doi: 10.1186/gb-2011-12-8-r74.


Determining nuclear shape: the role of farnesylated nuclear membrane proteins.

Polychronidou M, Grobhans J.

Nucleus. 2011 Jan-Feb;2(1):17-23. doi: 10.4161/nucl.2.1.13992.


Investigating the purpose of prelamin A processing.

Davies BS, Coffinier C, Yang SH, Barnes RH 2nd, Jung HJ, Young SG, Fong LG.

Nucleus. 2011 Jan-Feb;2(1):4-9. doi: 10.1093/hmg/ddq158. Review.


Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria.

Hernandez L, Roux KJ, Wong ES, Mounkes LC, Mutalif R, Navasankari R, Rai B, Cool S, Jeong JW, Wang H, Lee HS, Kozlov S, Grunert M, Keeble T, Jones CM, Meta MD, Young SG, Daar IO, Burke B, Perantoni AO, Stewart CL.

Dev Cell. 2010 Sep 14;19(3):413-25. doi: 10.1016/j.devcel.2010.08.013.

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