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Items: 20


Recurrent mutations in a SERPINC1 hotspot associate with venous thrombosis without apparent antithrombin deficiency.

Zeng W, Hu B, Tang L, You YY, Toderici M, de la Morena-Barrio ME, Corral J, Hu Y.

Oncotarget. 2017 Sep 28;8(48):84417-84425. doi: 10.18632/oncotarget.21365. eCollection 2017 Oct 13.


Conformational preludes to the latency transition in PAI-1 as determined by atomistic computer simulations and hydrogen/deuterium-exchange mass spectrometry.

Petersen M, Madsen JB, Jørgensen TJD, Trelle MB.

Sci Rep. 2017 Jul 26;7(1):6636. doi: 10.1038/s41598-017-06290-0.


A hydrophobic patch surrounding Trp154 in human neuroserpin controls the helix F dynamics with implications in inhibition and aggregation.

Ali MF, Kaushik A, Kapil C, Gupta D, Jairajpuri MA.

Sci Rep. 2017 Feb 23;7:42987. doi: 10.1038/srep42987.


Structural dynamics associated with intermediate formation in an archetypal conformational disease.

Nyon MP, Segu L, Cabrita LD, Lévy GR, Kirkpatrick J, Roussel BD, Patschull AO, Barrett TE, Ekeowa UI, Kerr R, Waudby CA, Kalsheker N, Hill M, Thalassinos K, Lomas DA, Christodoulou J, Gooptu B.

Structure. 2012 Mar 7;20(3):504-12. doi: 10.1016/j.str.2012.01.012.


Hepatic fibrosis and carcinogenesis in α1-antitrypsin deficiency: a prototype for chronic tissue damage in gain-of-function disorders.

Perlmutter DH, Silverman GA.

Cold Spring Harb Perspect Biol. 2011 Mar 1;3(3). pii: a005801. doi: 10.1101/cshperspect.a005801. Review.


Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes.

Garrett M, Fullaondo A, Troxler L, Micklem G, Gubb D.

BMC Genomics. 2009 Oct 22;10:489. doi: 10.1186/1471-2164-10-489.


Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1.

Soukup SF, Culi J, Gubb D.

PLoS Genet. 2009 Jun;5(6):e1000532. doi: 10.1371/journal.pgen.1000532. Epub 2009 Jun 26.


Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates.

Mallya M, Phillips RL, Saldanha SA, Gooptu B, Brown SC, Termine DJ, Shirvani AM, Wu Y, Sifers RN, Abagyan R, Lomas DA.

J Med Chem. 2007 Nov 1;50(22):5357-63. Epub 2007 Oct 5.


Probing the local conformational change of alpha1-antitrypsin.

Baek JH, Im H, Kang UB, Seong KM, Lee C, Kim J, Yu MH.

Protein Sci. 2007 Sep;16(9):1842-50. Epub 2007 Jul 27.


L-asparaginase-induced antithrombin type I deficiency: implications for conformational diseases.

Hernández-Espinosa D, Miñano A, Martínez C, Pérez-Ceballos E, Heras I, Fuster JL, Vicente V, Corral J.

Am J Pathol. 2006 Jul;169(1):142-53.


An overview of the serpin superfamily.

Law RH, Zhang Q, McGowan S, Buckle AM, Silverman GA, Wong W, Rosado CJ, Langendorf CG, Pike RN, Bird PI, Whisstock JC.

Genome Biol. 2006;7(5):216. Epub 2006 May 30. Review.


Alpha1-antitrypsin deficiency. 4: Molecular pathophysiology.

Lomas DA, Parfrey H.

Thorax. 2004 Jun;59(6):529-35. Review.


The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2.

Green C, Levashina E, McKimmie C, Dafforn T, Reichhart JM, Gubb D.

Genetics. 2000 Nov;156(3):1117-27.


Heteropolymerization of S, I, and Z alpha1-antitrypsin and liver cirrhosis.

Mahadeva R, Chang WS, Dafforn TR, Oakley DJ, Foreman RC, Calvin J, Wight DG, Lomas DA.

J Clin Invest. 1999 Apr;103(7):999-1006.


Genetics and respiratory disease. 2. Alpha 1-antitrypsin deficiency, cirrhosis and emphysema.

Mahadeva R, Lomas DA.

Thorax. 1998 Jun;53(6):501-5. Review. No abstract available.


Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins.

Chang WS, Whisstock J, Hopkins PC, Lesk AM, Carrell RW, Wardell MR.

Protein Sci. 1997 Jan;6(1):89-98.


Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy.

Koloczek H, Banbula A, Salvesen GS, Potempa J.

Protein Sci. 1996 Nov;5(11):2226-35.


Probing serpin reactive-loop conformations by proteolytic cleavage.

Chang WS, Wardell MR, Lomas DA, Carrell RW.

Biochem J. 1996 Mar 1;314 ( Pt 2):647-53.


Studies of serpins unfold at a feverish pace.

Madison EL.

J Clin Invest. 1994 Dec;94(6):2174-5. No abstract available.

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