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DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma.

Cao Y, Ke R, Wang S, Zhu X, Chen J, Huang C, Jiang Y, Lv L.

Oncol Lett. 2017 Jun;13(6):4109-4116. doi: 10.3892/ol.2017.5999. Epub 2017 Apr 6.


Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.

Kozuki T, Chikamori K, Surleac MD, Micluta MA, Petrescu AJ, Norris EJ, Elson P, Hoeltge GA, Grabowski DR, Porter ACG, Ganapathi RN, Ganapathi MK.

Nucleic Acids Res. 2017 Jun 2;45(10):5995-6010. doi: 10.1093/nar/gkx325.


Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells.

Chang YW, Singh KP.

PLoS One. 2017 Mar 21;12(3):e0174227. doi: 10.1371/journal.pone.0174227. eCollection 2017.


Inhibition of DNA Topoisomerase Type IIα (TOP2A) by Mitoxantrone and Its Halogenated Derivatives: A Combined Density Functional and Molecular Docking Study.

Abu Saleh M, Solayman M, Hoque MM, Khan MA, Sarwar MG, Halim MA.

Biomed Res Int. 2016;2016:6817502. doi: 10.1155/2016/6817502. Epub 2016 Feb 15.


The Mechanistic Targets of Antifungal Agents: An Overview.

Mazu TK, Bricker BA, Flores-Rozas H, Ablordeppey SY.

Mini Rev Med Chem. 2016;16(7):555-78. Review.


Allelic imbalance at the HER2/TOP2A locus in breast cancer.

Huijsmans CJ, van den Brule AJ, Rigter H, Poodt J, van der Linden JC, Savelkoul PH, Hilbink M, Hermans MH.

Diagn Pathol. 2015 May 29;10:56. doi: 10.1186/s13000-015-0289-x.


TOP2A amplification and overexpression in hepatocellular carcinoma tissues.

Panvichian R, Tantiwetrueangdet A, Angkathunyakul N, Leelaudomlipi S.

Biomed Res Int. 2015;2015:381602. doi: 10.1155/2015/381602. Epub 2015 Jan 28.


Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery.

Balaña-Fouce R, Alvarez-Velilla R, Fernández-Prada C, García-Estrada C, Reguera RM.

Int J Parasitol Drugs Drug Resist. 2014 Aug 24;4(3):326-37. doi: 10.1016/j.ijpddr.2014.07.006. eCollection 2014 Dec. Review.


Topoisomerase IIα in chromosome instability and personalized cancer therapy.

Chen T, Sun Y, Ji P, Kopetz S, Zhang W.

Oncogene. 2015 Jul 30;34(31):4019-31. doi: 10.1038/onc.2014.332. Epub 2014 Oct 20. Review.


Mechanisms regulating resistance to inhibitors of topoisomerase II.

Ganapathi RN, Ganapathi MK.

Front Pharmacol. 2013 Aug 1;4:89. doi: 10.3389/fphar.2013.00089. eCollection 2013.


Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs.

Baikar S, Malpathak N.

Pharmacogn Rev. 2010 Jan;4(7):12-26. doi: 10.4103/0973-7847.65320.


A tri-marker proliferation index predicts biochemical recurrence after surgery for prostate cancer.

Malhotra S, Lapointe J, Salari K, Higgins JP, Ferrari M, Montgomery K, van de Rijn M, Brooks JD, Pollack JR.

PLoS One. 2011;6(5):e20293. doi: 10.1371/journal.pone.0020293. Epub 2011 May 23.


Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells.

Gardner L, Malik R, Shimizu Y, Mullins N, ElShamy WM.

Breast Cancer Res. 2011 May 19;13(3):R53. doi: 10.1186/bcr2884.


Chromosome breakage is regulated by the interaction of the BLM helicase and topoisomerase IIalpha.

Russell B, Bhattacharyya S, Keirsey J, Sandy A, Grierson P, Perchiniak E, Kavecansky J, Acharya S, Groden J.

Cancer Res. 2011 Jan 15;71(2):561-71. doi: 10.1158/0008-5472.CAN-10-1727. Epub 2011 Jan 11.


The function of DNA topoisomerase IIβ in neuronal development.

Heng X, Le WD.

Neurosci Bull. 2010 Oct;26(5):411-6. doi: 10.1007/s12264-010-0625-9. Review.


Inferring the transcriptional landscape of bovine skeletal muscle by integrating co-expression networks.

Hudson NJ, Reverter A, Wang Y, Greenwood PL, Dalrymple BP.

PLoS One. 2009 Oct 1;4(10):e7249. doi: 10.1371/journal.pone.0007249.


Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish.

Dovey M, Patton EE, Bowman T, North T, Goessling W, Zhou Y, Zon LI.

Mol Cell Biol. 2009 Jul;29(13):3746-53. doi: 10.1128/MCB.01684-08. Epub 2009 Apr 20.


Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.

Grozav AG, Chikamori K, Kozuki T, Grabowski DR, Bukowski RM, Willard B, Kinter M, Andersen AH, Ganapathi R, Ganapathi MK.

Nucleic Acids Res. 2009 Feb;37(2):382-92. doi: 10.1093/nar/gkn934. Epub 2008 Nov 29.


Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1.

Wyles JP, Wu Z, Mirski SE, Cole SP.

Nucleic Acids Res. 2007;35(12):4076-85. Epub 2007 Jun 12.

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