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Knockdown of EWSR1/FLI1 expression alters the transcriptome of Ewing sarcoma cells in vitro.

Wang J, Jiang W, Yan Y, Chen C, Yu Y, Wang B, Zhao H.

J Bone Oncol. 2016 May 30;5(4):153-158. doi: 10.1016/j.jbo.2016.05.006.


Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing's sarcoma through the PI3K/Akt pathway.

Ren C, Ren T, Yang K, Wang S, Bao X, Zhang F, Guo W.

J Exp Clin Cancer Res. 2016 Mar 11;35:44. doi: 10.1186/s13046-016-0321-3.


Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting.

Theisen ER, Pishas KI, Saund RS, Lessnick SL.

Oncotarget. 2016 Apr 5;7(14):17616-30. doi: 10.18632/oncotarget.7124. Review.


Twenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?

Lawlor ER, Sorensen PH.

Crit Rev Oncog. 2015;20(3-4):155-71. Review.


PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1.

Giorgi C, Boro A, Rechfeld F, Lopez-Garcia LA, Gierisch ME, Schäfer BW, Niggli FK.

Oncotarget. 2015 Oct 6;6(30):28895-910. doi: 10.18632/oncotarget.5000.


Structure-function based molecular relationships in Ewing's sarcoma.

Todorova R.

Biomed Res Int. 2015;2015:798426. doi: 10.1155/2015/798426. Review.


Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma.

Chaturvedi A, Hoffman LM, Jensen CC, Lin YC, Grossmann AH, Randall RL, Lessnick SL, Welm AL, Beckerle MC.

Mol Biol Cell. 2014 Sep 15;25(18):2695-709. doi: 10.1091/mbc.E14-01-0007.


EWS and RE1-Silencing Transcription Factor Inhibit Neuronal Phenotype Development and Oncogenic Transformation in Ewing Sarcoma.

Sankar S, Gomez NC, Bell R, Patel M, Davis IJ, Lessnick SL, Luo W.

Genes Cancer. 2013 May;4(5-6):213-23. doi: 10.1177/1947601913489569.


Cancer stem cells in pediatric sarcomas.

Dela Cruz FS.

Front Oncol. 2013 Jun 27;3:168. doi: 10.3389/fonc.2013.00168.


EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice.

Yamada K, Ohno T, Aoki H, Semi K, Watanabe A, Moritake H, Shiozawa S, Kunisada T, Kobayashi Y, Toguchida J, Shimizu K, Hara A, Yamada Y.

J Clin Invest. 2013 Feb;123(2):600-10. doi: 10.1172/JCI63572.


Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

Sankar S, Bell R, Stephens B, Zhuo R, Sharma S, Bearss DJ, Lessnick SL.

Oncogene. 2013 Oct 17;32(42):5089-100. doi: 10.1038/onc.2012.525.


The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma.

Chaturvedi A, Hoffman LM, Welm AL, Lessnick SL, Beckerle MC.

Genes Cancer. 2012 Feb;3(2):102-16. doi: 10.1177/1947601912457024.


ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors.

Oh S, Shin S, Janknecht R.

Biochim Biophys Acta. 2012 Aug;1826(1):1-12. doi: 10.1016/j.bbcan.2012.02.002. Review.


Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.

Herrero-Martin D, Fourtouna A, Niedan S, Riedmann LT, Schwentner R, Aryee DN.

Sarcoma. 2011;2011:352580. doi: 10.1155/2011/352580.


Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription.

Patel M, Simon JM, Iglesia MD, Wu SB, McFadden AW, Lieb JD, Davis IJ.

Genome Res. 2012 Feb;22(2):259-70. doi: 10.1101/gr.125666.111.


Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets.

Lessnick SL, Ladanyi M.

Annu Rev Pathol. 2012;7:145-59. doi: 10.1146/annurev-pathol-011110-130237. Review.


Promiscuous partnerships in Ewing's sarcoma.

Sankar S, Lessnick SL.

Cancer Genet. 2011 Jul;204(7):351-65. doi: 10.1016/j.cancergen.2011.07.008. Review.


Copy Number Alterations and Methylation in Ewing's Sarcoma.

Jahromi MS, Jones KB, Schiffman JD.

Sarcoma. 2011;2011:362173. doi: 10.1155/2011/362173.


Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma.

Ban J, Jug G, Mestdagh P, Schwentner R, Kauer M, Aryee DN, Schaefer KL, Nakatani F, Scotlandi K, Reiter M, Strunk D, Speleman F, Vandesompele J, Kovar H.

Oncogene. 2011 May 5;30(18):2173-80. doi: 10.1038/onc.2010.581.


Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family.

Kovar H.

Sarcoma. 2011;2011:837474. doi: 10.1155/2011/837474.

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