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Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.

LaRochelle JR, Fodor M, Xu X, Durzynska I, Fan L, Stams T, Chan HM, LaMarche MJ, Chopra R, Wang P, Fortin PD, Acker MG, Blacklow SC.

Biochemistry. 2016 Apr 19;55(15):2269-77. doi: 10.1021/acs.biochem.5b01287.


The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events.

Craig J, Mikhailenko I, Noyes N, Migliorini M, Strickland DK.

PLoS One. 2013 Jul 26;8(7):e70432. doi: 10.1371/journal.pone.0070432.


A single amino acid substitution converts a transmembrane protein activator of the platelet-derived growth factor β receptor into an inhibitor.

Petti LM, Talbert-Slagle K, Hochstrasser ML, DiMaio D.

J Biol Chem. 2013 Sep 20;288(38):27273-86. doi: 10.1074/jbc.M113.470054.


Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.

Ruusala A, Pawson T, Heldin CH, Aspenström P.

J Biol Chem. 2008 Oct 31;283(44):30034-44. doi: 10.1074/jbc.M800913200.


Structure-based kinetic models of modular signaling protein function: focus on Shp2.

Barua D, Faeder JR, Haugh JM.

Biophys J. 2007 Apr 1;92(7):2290-300.


Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells.

Takeuchi H, Kanzawa T, Kondo Y, Kondo S.

Br J Cancer. 2004 Mar 8;90(5):1069-75.


Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.

Persson C, Sävenhed C, Bourdeau A, Tremblay ML, Markova B, Böhmer FD, Haj FG, Neel BG, Elson A, Heldin CH, Rönnstrand L, Ostman A, Hellberg C.

Mol Cell Biol. 2004 Mar;24(5):2190-201.


Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation.

Ferjoux G, Lopez F, Esteve JP, Ferrand A, Vivier E, Vely F, Saint-Laurent N, Pradayrol L, Buscail L, Susini C.

Mol Biol Cell. 2003 Sep;14(9):3911-28.


Profiling the global tyrosine phosphorylation state by Src homology 2 domain binding.

Nollau P, Mayer BJ.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13531-6.


Vav family proteins couple to diverse cell surface receptors.

Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W.

Mol Cell Biol. 2000 Sep;20(17):6364-73.


Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.

Heinrich PC, Behrmann I, Müller-Newen G, Schaper F, Graeve L.

Biochem J. 1998 Sep 1;334 ( Pt 2):297-314. Review.


Molecular characterization of a tyrosine-specific protein phosphatase encoded by a stress-responsive gene in Arabidopsis.

Xu Q, Fu HH, Gupta R, Luan S.

Plant Cell. 1998 May;10(5):849-57. Erratum in: Plant Cell 1998 Oct;10(10):1769.

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