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Items: 9


Withaferin-A--A Natural Anticancer Agent with Pleitropic Mechanisms of Action.

Lee IC, Choi BY.

Int J Mol Sci. 2016 Mar 4;17(3):290. doi: 10.3390/ijms17030290. Review.


Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system.

Devkar ST, Kandhare AD, Sloley BD, Jagtap SD, Lin J, Tam YK, Katyare SS, Bodhankar SL, Hegde MV.

J Adv Pharm Technol Res. 2015 Oct-Dec;6(4):159-64. doi: 10.4103/2231-4040.165023.


Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone.

Vyas AR, Singh SV.

AAPS J. 2014 Jan;16(1):1-10. doi: 10.1208/s12248-013-9531-1. Epub 2013 Sep 18. Review.


Withaferin A induces proteasome inhibition, endoplasmic reticulum stress, the heat shock response and acquisition of thermotolerance.

Khan S, Rammeloo AW, Heikkila JJ.

PLoS One. 2012;7(11):e50547. doi: 10.1371/journal.pone.0050547. Epub 2012 Nov 30.


Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences.

Vaishnavi K, Saxena N, Shah N, Singh R, Manjunath K, Uthayakumar M, Kanaujia SP, Kaul SC, Sekar K, Wadhwa R.

PLoS One. 2012;7(9):e44419. doi: 10.1371/journal.pone.0044419. Epub 2012 Sep 4.


Withaferin a suppresses estrogen receptor-α expression in human breast cancer cells.

Hahm ER, Lee J, Huang Y, Singh SV.

Mol Carcinog. 2011 Aug;50(8):614-24. doi: 10.1002/mc.20760. Epub 2011 Mar 22.


Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells.

Lee J, Hahm ER, Singh SV.

Carcinogenesis. 2010 Nov;31(11):1991-8. doi: 10.1093/carcin/bgq175. Epub 2010 Aug 19.


Ayurvedic medicine constituent withaferin a causes G2 and M phase cell cycle arrest in human breast cancer cells.

Stan SD, Zeng Y, Singh SV.

Nutr Cancer. 2008;60 Suppl 1:51-60. doi: 10.1080/01635580802381477.


Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo.

Stan SD, Hahm ER, Warin R, Singh SV.

Cancer Res. 2008 Sep 15;68(18):7661-9. doi: 10.1158/0008-5472.CAN-08-1510.

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