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A fully integrated new paradigm for lithium's mode of action - lithium utilizes latent cellular fail-safe mechanisms.

van Woerkom AE.

Neuropsychiatr Dis Treat. 2017 Jan 31;13:275-302. doi: 10.2147/NDT.S123612. eCollection 2017.


Metalloneurochemistry and the Pierian Spring: 'Shallow Draughts Intoxicate the Brain'.

Goldberg JM, Loas A, Lippard SJ.

Isr J Chem. 2016 Oct;56(9-10):791-802. doi: 10.1002/ijch.201600034. Epub 2016 Jul 29.


IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.

Sade Y, Toker L, Kara NZ, Einat H, Rapoport S, Moechars D, Berry GT, Bersudsky Y, Agam G.

Transl Psychiatry. 2016 Dec 6;6(12):e968. doi: 10.1038/tp.2016.217.


Valproate Induces the Unfolded Protein Response by Increasing Ceramide Levels.

Jadhav S, Russo S, Cottier S, Schneiter R, Cowart A, Greenberg ML.

J Biol Chem. 2016 Oct 14;291(42):22253-22261. Epub 2016 Sep 1.


Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models.

Choi CH, Schoenfeld BP, Bell AJ, Hinchey J, Rosenfelt C, Gertner MJ, Campbell SR, Emerson D, Hinchey P, Kollaros M, Ferrick NJ, Chambers DB, Langer S, Sust S, Malik A, Terlizzi AM, Liebelt DA, Ferreiro D, Sharma A, Koenigsberg E, Choi RJ, Louneva N, Arnold SE, Featherstone RE, Siegel SJ, Zukin RS, McDonald TV, Bolduc FV, Jongens TA, McBride SM.

Front Behav Neurosci. 2016 Jun 30;10:136. doi: 10.3389/fnbeh.2016.00136. eCollection 2016.


Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme.

Ferruz N, Tresadern G, Pineda-Lucena A, De Fabritiis G.

Sci Rep. 2016 Jul 21;6:30275. doi: 10.1038/srep30275.


Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.

Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA; Members of the International Cohort Collection for Bipolar Disorder (ICCBD), Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK, Jones I, Jones L, Scolnick EM, Sklar P, Smoller JW, Lichtenstein P, Hultman C, Craddock N, Landén M, Smoller JW, Perlis RH, Lee PH, Castro VM, Hoffnagle AG, Sklar P, Stahl EA, Purcell SM, Ruderfer DM, Charney AW, Roussos P, Michele Pato CP, Medeiros H, Sobel J, Craddock N, Jones I, Forty L, Florio AD, Green E, Jones L, Gordon-Smith K, Landen M, Hultman C, Jureus A, Bergen S, McCarroll S, Moran J, Smoller JW, Chambert K, Belliveau RA.

Mol Psychiatry. 2016 Sep;21(9):1290-7. doi: 10.1038/mp.2015.165. Epub 2015 Oct 27. Erratum in: Mol Psychiatry. 2017 Aug;22(8):1223.


The potential of metabolomic analysis techniques for the characterisation of α1-adrenergic receptors in cultured N1E-115 mouse neuroblastoma cells.

Wenner MI, Maker GL, Dawson LF, Drummond PD, Mullaney I.

Cytotechnology. 2016 Aug;68(4):1561-75. doi: 10.1007/s10616-015-9915-4. Epub 2015 Sep 25.


Inositol synthesis regulates the activation of GSK-3α in neuronal cells.

Ye C, Greenberg ML.

J Neurochem. 2015 Apr;133(2):273-83. doi: 10.1111/jnc.12978. Epub 2014 Nov 17.


Genetic variations of PIP4K2A confer vulnerability to poor antipsychotic response in severely ill schizophrenia patients.

Kaur H, Jajodia A, Grover S, Baghel R, Gupta M, Jain S, Kukreti R.

PLoS One. 2014 Jul 15;9(7):e102556. doi: 10.1371/journal.pone.0102556. eCollection 2014.


Molecular actions and clinical pharmacogenetics of lithium therapy.

Can A, Schulze TG, Gould TD.

Pharmacol Biochem Behav. 2014 Aug;123:3-16. doi: 10.1016/j.pbb.2014.02.004. Epub 2014 Feb 15. Review.


Lithium: the pharmacodynamic actions of the amazing ion.

Brown KM, Tracy DK.

Ther Adv Psychopharmacol. 2013 Jun;3(3):163-76. doi: 10.1177/2045125312471963.


The unfolded protein response has a protective role in yeast models of classic galactosemia.

De-Souza EA, Pimentel FS, Machado CM, Martins LS, da-Silva WS, Montero-Lomelí M, Masuda CA.

Dis Model Mech. 2014 Jan;7(1):55-61. doi: 10.1242/dmm.012641. Epub 2013 Sep 25.


Inositol-related gene knockouts mimic lithium's effect on mitochondrial function.

Toker L, Bersudsky Y, Plaschkes I, Chalifa-Caspi V, Berry GT, Buccafusca R, Moechars D, Belmaker RH, Agam G.

Neuropsychopharmacology. 2014 Jan;39(2):319-28. doi: 10.1038/npp.2013.194. Epub 2013 Aug 8.


Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae.

Ye C, Bandara WM, Greenberg ML.

J Biol Chem. 2013 Aug 23;288(34):24898-908. doi: 10.1074/jbc.M113.493353. Epub 2013 Jul 2.


Rab35 regulates cadherin-mediated adherens junction formation and myoblast fusion.

Charrasse S, Comunale F, De Rossi S, Echard A, Gauthier-Rouvière C.

Mol Biol Cell. 2013 Feb;24(3):234-45. doi: 10.1091/mbc.E12-02-0167. Epub 2012 Nov 28.


Converging levels of analysis on a genomic hotspot for psychosis: insights from 22q11.2 deletion syndrome.

Schreiner MJ, Lazaro MT, Jalbrzikowski M, Bearden CE.

Neuropharmacology. 2013 May;68:157-73. doi: 10.1016/j.neuropharm.2012.09.012. Epub 2012 Oct 23. Review.


Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx.

Jarrard RE, Wang Y, Salyer AE, Pratt EP, Soderling IM, Guerra ML, Lange AM, Broderick HJ, Hockerman GH.

Mol Pharmacol. 2013 Jan;83(1):191-205. doi: 10.1124/mol.112.081943. Epub 2012 Oct 15.


Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.

Singh N, Halliday AC, Knight M, Lack NA, Lowe E, Churchill GC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1149-52. doi: 10.1107/S1744309112035191. Epub 2012 Sep 22.

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