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Items: 1 to 20 of 61

1.
2.

Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2.

Shearstone JR, Golonzhka O, Chonkar A, Tamang D, van Duzer JH, Jones SS, Jarpe MB.

PLoS One. 2016 Apr 13;11(4):e0153767. doi: 10.1371/journal.pone.0153767.

3.

Thalidomide is more efficient than sodium butyrate in enhancing GATA-1 and EKLF gene expression in erythroid progenitors derived from HSCs with β-globin gene mutation.

Jalali Far MA, Dehghani Fard A, Hajizamani S, Mossahebi-Mohammadi M, Yaghooti H, Saki N.

Int J Hematol Oncol Stem Cell Res. 2016 Jan 1;10(1):37-41.

4.

Regulation of the fetal hemoglobin silencing factor BCL11A.

Basak A, Sankaran VG.

Ann N Y Acad Sci. 2016 Mar;1368(1):25-30. doi: 10.1111/nyas.13024.

PMID:
26963603
5.

The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).

Rivers A, Vaitkus K, Ibanez V, Ruiz MA, Jagadeeswaran R, Saunthararajah Y, Cui S, Engel JD, DeSimone J, Lavelle D.

Haematologica. 2016 Jun;101(6):688-97. doi: 10.3324/haematol.2015.140749.

6.

Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice.

Boosalis MS, Sangerman JI, White GL, Wolf RF, Shen L, Dai Y, White E, Makala LH, Li B, Pace BS, Nouraie M, Faller DV, Perrine SP.

PLoS One. 2015 Dec 29;10(12):e0144660. doi: 10.1371/journal.pone.0144660.

7.

Sickle Cell Disease: Reappraisal of the Role of Foetal Haemoglobin Levels in the Frequency of Vaso-Occlusive Crisis.

Antwi-Boasiako C, Frimpong E, Ababio GK, Dzudzor B, Ekem I, Gyan B, Sodzi-Tettey NA, Antwi DA.

Ghana Med J. 2015 Jun;49(2):102-6.

8.

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.

Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL.

Blood. 2015 Oct 15;126(16):1930-9. doi: 10.1182/blood-2015-06-649087.

9.

Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease.

Pace BS, Liu L, Li B, Makala LH.

Exp Biol Med (Maywood). 2015 Aug;240(8):1050-64. doi: 10.1177/1535370215596859. Review.

10.

Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation.

Ruiz MA, Rivers A, Ibanez V, Vaitkus K, Mahmud N, DeSimone J, Lavelle D.

Epigenetics. 2015;10(5):397-407. doi: 10.1080/15592294.2015.1039220.

11.

Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation.

Esrick EB, McConkey M, Lin K, Frisbee A, Ebert BL.

Am J Hematol. 2015 Jul;90(7):624-8. doi: 10.1002/ajh.24019.

12.

Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors.

Lessard S, Beaudoin M, Benkirane K, Lettre G.

Genome Med. 2015 Jan 20;7(1):1. doi: 10.1186/s13073-014-0122-2.

13.

A cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathies.

Peterson KR, Costa FC, Fedosyuk H, Neades RY, Chazelle AM, Zelenchuk L, Fonteles AH, Dalal P, Roy A, Chaguturu R, Li B, Pace BS.

PLoS One. 2014 Sep 16;9(9):e107006. doi: 10.1371/journal.pone.0107006.

14.

Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies.

Suzuki M, Yamamoto M, Engel JD.

Mol Cell Biol. 2014 Oct 1;34(19):3560-9. doi: 10.1128/MCB.00714-14. Review.

15.

Epigenetic regulation of fetal globin gene expression in adult erythroid cells.

Ginder GD.

Transl Res. 2015 Jan;165(1):115-25. doi: 10.1016/j.trsl.2014.05.002. Review.

16.

Evaluation of Novel Fetal Hemoglobin Inducer Drugs in Treatment of β-Hemoglobinopathy Disorders.

Fard AD, Hosseini SA, Shahjahani M, Salari F, Jaseb K.

Int J Hematol Oncol Stem Cell Res. 2013;7(3):47-54. Review.

17.

Evaluation of Signaling Pathways Involved in γ-Globin Gene Induction Using Fetal Hemoglobin Inducer Drugs.

Rahim F, Allahmoradi H, Salari F, Shahjahani M, Fard AD, Hosseini SA, Mousakhani H.

Int J Hematol Oncol Stem Cell Res. 2013;7(3):41-6. Review.

18.

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.

Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6518-23. doi: 10.1073/pnas.1303976110.

19.

Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.

Amaya M, Desai M, Gnanapragasam MN, Wang SZ, Zu Zhu S, Williams DC Jr, Ginder GD.

Blood. 2013 Apr 25;121(17):3493-501. doi: 10.1182/blood-2012-11-466227.

20.

The switch from fetal to adult hemoglobin.

Sankaran VG, Orkin SH.

Cold Spring Harb Perspect Med. 2013 Jan 1;3(1):a011643. doi: 10.1101/cshperspect.a011643.

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