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Items: 13


In vivo information-guided prediction approach for assessing the risks of drug-drug interactions associated with circulating inhibitory metabolites.

Hu ZY, Parker RB, Laizure SC.

Drug Metab Dispos. 2012 Aug;40(8):1487-94. doi: 10.1124/dmd.112.045799. Epub 2012 May 4.


Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G.

Chest. 2012 Feb;141(2 Suppl):e44S-e88S. doi: 10.1378/chest.11-2292. Review.


Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data?

Ito K, Chiba K, Horikawa M, Ishigami M, Mizuno N, Aoki J, Gotoh Y, Iwatsubo T, Kanamitsu S, Kato M, Kawahara I, Niinuma K, Nishino A, Sato N, Tsukamoto Y, Ueda K, Itoh T, Sugiyama Y.

AAPS PharmSci. 2002;4(4):E25.


Cytochrome P4502C9: an enzyme of major importance in human drug metabolism.

Miners JO, Birkett DJ.

Br J Clin Pharmacol. 1998 Jun;45(6):525-38. Review.


Plasma protein binding displacement interactions--why are they still regarded as clinically important?

Rolan PE.

Br J Clin Pharmacol. 1994 Feb;37(2):125-8. Review. No abstract available.


Disposition of warfarin enantiomers and metabolites in patients during multiple dosing with rac-warfarin.

Chan E, McLachlan AJ, Pegg M, MacKay AD, Cole RB, Rowland M.

Br J Clin Pharmacol. 1994 Jun;37(6):563-9.


Stereoselective drug disposition: potential for misinterpretation of drug disposition data.

Evans AM, Nation RL, Sansom LN, Bochner F, Somogyi AA.

Br J Clin Pharmacol. 1988 Dec;26(6):771-80.


Investigations into the potential effects of multiple dose ketorolac on the pharmacokinetics and pharmacodynamics of racemic warfarin.

Toon S, Holt BL, Mullins FG, Bullingham R, Aarons L, Rowland M.

Br J Clin Pharmacol. 1990 Nov;30(5):743-50.


Further insight into the stereoselective interaction between warfarin and cimetidine in man.

Niopas I, Toon S, Rowland M.

Br J Clin Pharmacol. 1991 Oct;32(4):508-11.


Stereoselective disposition of flurbiprofen in normal volunteers.

Knadler MP, Brater DC, Hall SD.

Br J Clin Pharmacol. 1992 Apr;33(4):369-75.

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