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Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells.

Chen HC, Chen PY, Wu MJ, Tai MH, Yen JH.

PLoS One. 2016 Sep 12;11(9):e0162414. doi: 10.1371/journal.pone.0162414. eCollection 2016.


Patched1 and Patched2 inhibit Smoothened non-cell autonomously.

Roberts B, Casillas C, Alfaro AC, Jägers C, Roelink H.

Elife. 2016 Aug 23;5. pii: e17634. doi: 10.7554/eLife.17634.


Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.

Li X, Saha P, Li J, Blobel G, Pfeffer SR.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10079-84. doi: 10.1073/pnas.1611956113. Epub 2016 Aug 22.


Structural basis of transcobalamin recognition by human CD320 receptor.

Alam A, Woo JS, Schmitz J, Prinz B, Root K, Chen F, Bloch JS, Zenobi R, Locher KP.

Nat Commun. 2016 Jul 14;7:12100. doi: 10.1038/ncomms12100.


Clues to NPC1-mediated cholesterol export from lysosomes.

Pfeffer SR.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):7941-3. doi: 10.1073/pnas.1608530113. Epub 2016 Jul 7. No abstract available.


A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model.

Wang HY, Quan C, Hu C, Xie B, Du Y, Chen L, Yang W, Yang L, Chen Q, Shen B, Hu B, Zheng Z, Zhu H, Huang X, Xu G, Chen S.

Biol Open. 2016 Jul 15;5(7):979-86. doi: 10.1242/bio.019802.


Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease.

Chen X, Wagener JF, Ghribi O, Geiger JD.

Front Aging Neurosci. 2016 Jun 8;8:129. doi: 10.3389/fnagi.2016.00129. eCollection 2016.


Total Synthesis of (+)-SCH 351448: Efficiency via Chemoselectivity and Redox-Economy Powered by Metal Catalysis.

Wang G, Krische MJ.

J Am Chem Soc. 2016 Jul 6;138(26):8088-91. doi: 10.1021/jacs.6b04917. Epub 2016 Jun 23.


Lipids, lysosomes, and autophagy.

Jaishy B, Abel ED.

J Lipid Res. 2016 Sep;57(9):1619-35. doi: 10.1194/jlr.R067520. Epub 2016 Jun 21. Review.


Structure of human Niemann-Pick C1 protein.

Li X, Wang J, Coutavas E, Shi H, Hao Q, Blobel G.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8212-7. doi: 10.1073/pnas.1607795113. Epub 2016 Jun 15.


Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture.

Ollikainen E, Tulamo R, Lehti S, Lee-Rueckert M, Hernesniemi J, Niemelä M, Ylä-Herttuala S, Kovanen PT, Frösen J.

J Neuropathol Exp Neurol. 2016 Jul;75(7):689-99. doi: 10.1093/jnen/nlw041. Epub 2016 Jun 9.


Variable expressivity and co-occurrence of LDLR and LDLRAP1 mutations in familial hypercholesterolemia: failure of the dominant and recessive dichotomy.

Fahed AC, Khalaf R, Salloum R, Andary RR, Safa R, El-Rassy I, Moubarak E, Azar ST, Bitar FF, Nemer G.

Mol Genet Genomic Med. 2016 Feb 24;4(3):283-91. doi: 10.1002/mgg3.203. eCollection 2016 May.


Genistein upregulates LDLR levels via JNK-mediated activation of SREBP-2.

Kartawijaya M, Han HW, Kim Y, Lee SM.

Food Nutr Res. 2016 May 20;60:31120. doi: 10.3402/fnr.v60.31120. eCollection 2016.


The Apoe(-/-) mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction.

Lo Sasso G, Schlage WK, Boué S, Veljkovic E, Peitsch MC, Hoeng J.

J Transl Med. 2016 May 20;14(1):146. doi: 10.1186/s12967-016-0901-1. Review.


Effects of single-dose morning and evening administration of pravastatin on antioxidant markers in cholesterol-fed rabbits.

Kamal SM.

J Exp Pharmacol. 2011 May 12;3:51-8. doi: 10.2147/JEP.S19449. eCollection 2011.


The genetics and screening of familial hypercholesterolaemia.

Henderson R, O'Kane M, McGilligan V, Watterson S.

J Biomed Sci. 2016 Apr 16;23:39. doi: 10.1186/s12929-016-0256-1. Review.


Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats.

Jia L, Song N, Yang G, Ma Y, Li X, Lu R, Cao H, Zhang N, Zhu M, Wang J, Leng X, Cao Y, Du Y, Xu Y.

Mol Med Rep. 2016 Jun;13(6):4627-35. doi: 10.3892/mmr.2016.5133. Epub 2016 Apr 14.


A lysosome-centered view of nutrient homeostasis.

Mony VK, Benjamin S, O'Rourke EJ.

Autophagy. 2016;12(4):619-31. doi: 10.1080/15548627.2016.1147671.


Update on Mechanisms of Renal Tubule Injury Caused by Advanced Glycation End Products.

Sun H, Yuan Y, Sun Z.

Biomed Res Int. 2016;2016:5475120. doi: 10.1155/2016/5475120. Epub 2016 Feb 29.

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