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Items: 1 to 20 of 27


Why Ser and not Thr brokers catalysis in the trypsin fold.

Pelc LA, Chen Z, Gohara DW, Vogt AD, Pozzi N, Di Cera E.

Biochemistry. 2015 Feb 24;54(7):1457-64. doi: 10.1021/acs.biochem.5b00014. Epub 2015 Feb 11.


Design of activated serine-containing catalytic triads with atomic-level accuracy.

Rajagopalan S, Wang C, Yu K, Kuzin AP, Richter F, Lew S, Miklos AE, Matthews ML, Seetharaman J, Su M, Hunt JF, Cravatt BF, Baker D.

Nat Chem Biol. 2014 May;10(5):386-91. doi: 10.1038/nchembio.1498. Epub 2014 Apr 6.


Use of anion-aromatic interactions to position the general base in the ketosteroid isomerase active site.

Schwans JP, Sunden F, Lassila JK, Gonzalez A, Tsai Y, Herschlag D.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11308-13. doi: 10.1073/pnas.1206710110. Epub 2013 Jun 24.


Recombining low homology, functionally rich regions of bacterial subtilisins by combinatorial fragment exchange.

Jones DD.

PLoS One. 2011;6(9):e24319. doi: 10.1371/journal.pone.0024319. Epub 2011 Sep 7.


Structure and catalysis of acylaminoacyl peptidase: closed and open subunits of a dimer oligopeptidase.

Harmat V, Domokos K, Menyhárd DK, Palló A, Szeltner Z, Szamosi I, Beke-Somfai T, Náray-Szabó G, Polgár L.

J Biol Chem. 2011 Jan 21;286(3):1987-98. doi: 10.1074/jbc.M110.169862. Epub 2010 Nov 16.


Mutational and biochemical analysis of the DNA-entry nuclease EndA from Streptococcus pneumoniae.

Midon M, Schäfer P, Pingoud A, Ghosh M, Moon AF, Cuneo MJ, London RE, Meiss G.

Nucleic Acids Res. 2011 Jan;39(2):623-34. doi: 10.1093/nar/gkq802. Epub 2010 Sep 15.


Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).

Goettig P, Magdolen V, Brandstetter H.

Biochimie. 2010 Nov;92(11):1546-67. doi: 10.1016/j.biochi.2010.06.022. Epub 2010 Jul 6. Review.


Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis.

Brown NG, Shanker S, Prasad BV, Palzkill T.

J Biol Chem. 2009 Nov 27;284(48):33703-12. doi: 10.1074/jbc.M109.053819. Epub 2009 Oct 6.


Brought to life: targeted activation of enzyme function with small molecules.

Bishop AC, Chen VL.

J Chem Biol. 2009 Mar;2(1):1-9. doi: 10.1007/s12154-008-0012-4. Epub 2008 Sep 20.


The chemical biology of protein phosphorylation.

Tarrant MK, Cole PA.

Annu Rev Biochem. 2009;78:797-825. doi: 10.1146/annurev.biochem.78.070907.103047. Review.


Medical bioremediation of age-related diseases.

Mathieu JM, Schloendorn J, Rittmann BE, Alvarez PJ.

Microb Cell Fact. 2009 Apr 9;8:21. doi: 10.1186/1475-2859-8-21.


A remodelled protease that cleaves phosphotyrosine substrates.

Knight ZA, Garrison JL, Chan K, King DS, Shokat KM.

J Am Chem Soc. 2007 Sep 26;129(38):11672-3. Epub 2007 Sep 6. No abstract available.


The QM/MM molecular dynamics and free energy simulations of the acylation reaction catalyzed by the serine-carboxyl peptidase kumamolisin-As.

Xu Q, Guo HB, Wlodawer A, Nakayama T, Guo H.

Biochemistry. 2007 Mar 27;46(12):3784-92. Epub 2007 Feb 28.


PrrC-anticodon nuclease: functional organization of a prototypical bacterial restriction RNase.

Blanga-Kanfi S, Amitsur M, Azem A, Kaufmann G.

Nucleic Acids Res. 2006 Jun 21;34(11):3209-19. Print 2006.


Conversion of trypsin to a functional threonine protease.

Baird TT Jr, Wright WD, Craik CS.

Protein Sci. 2006 Jun;15(6):1229-38. Epub 2006 May 2.


Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity.

Varadarajan N, Gam J, Olsen MJ, Georgiou G, Iverson BL.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6855-60. Epub 2005 May 2.


Zeptomole detection of a viral nucleic acid using a target-activated ribozyme.

Vaish NK, Jadhav VR, Kossen K, Pasko C, Andrews LE, McSwiggen JA, Polisky B, Seiwert SD.

RNA. 2003 Sep;9(9):1058-72.


A clogged gutter mechanism for protease inhibitors.

Radisky ES, Koshland DE Jr.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10316-21. Epub 2002 Jul 25.


Substrate-assisted catalysis: molecular basis and biological significance.

Dall'Acqua W, Carter P.

Protein Sci. 2000 Jan;9(1):1-9. Review.


Breaking the low barrier hydrogen bond in a serine protease.

Kidd RD, Sears P, Huang DH, Witte K, Wong CH, Farber GK.

Protein Sci. 1999 Feb;8(2):410-7.

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