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Cryo-EM structure of human DNA-PK holoenzyme.

Yin X, Liu M, Tian Y, Wang J, Xu Y.

Cell Res. 2017 Nov;27(11):1341-1350. doi: 10.1038/cr.2017.110. Epub 2017 Aug 25.


DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.

Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH.

Cell Metab. 2017 May 2;25(5):1135-1146.e7. doi: 10.1016/j.cmet.2017.04.008. Erratum in: Cell Metab. 2017 Aug 1;26(2):447.


Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition.

Huang Z, Zhou X, He Y, Ke X, Wen Y, Zou F, Chen X.

Sci Rep. 2016 Dec 2;6:38072. doi: 10.1038/srep38072.


ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation.

Elaimy AL, Ahsan A, Marsh K, Pratt WB, Ray D, Lawrence TS, Nyati MK.

Oncotarget. 2016 Dec 13;7(50):82450-82457. doi: 10.18632/oncotarget.12557.


Hsp90: A New Player in DNA Repair?

Pennisi R, Ascenzi P, di Masi A.

Biomolecules. 2015 Oct 16;5(4):2589-618. doi: 10.3390/biom5042589. Review. Erratum in: Biomolecules. 2016 Oct 18;6(4):.


HSP90AB1: Helping the good and the bad.

Haase M, Fitze G.

Gene. 2016 Jan 10;575(2 Pt 1):171-86. doi: 10.1016/j.gene.2015.08.063. Epub 2015 Sep 7. Review. No abstract available.


Regulation and function of the human HSP90AA1 gene.

Zuehlke AD, Beebe K, Neckers L, Prince T.

Gene. 2015 Oct 1;570(1):8-16. doi: 10.1016/j.gene.2015.06.018. Epub 2015 Jun 10. Review.


Dynamic structures in DNA damage responses & cancer.

Tainer JA.

Prog Biophys Mol Biol. 2015 Mar;117(2-3):129-33. doi: 10.1016/j.pbiomolbio.2015.04.003. No abstract available.


The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis.

Jette N, Lees-Miller SP.

Prog Biophys Mol Biol. 2015 Mar;117(2-3):194-205. doi: 10.1016/j.pbiomolbio.2014.12.003. Epub 2014 Dec 27. Review.


Alternative approaches to Hsp90 modulation for the treatment of cancer.

Hall JA, Forsberg LK, Blagg BS.

Future Med Chem. 2014 Sep;6(14):1587-605. doi: 10.4155/fmc.14.89.


Plastid casein kinase 2 knockout reduces abscisic acid (ABA) sensitivity, thermotolerance, and expression of ABA- and heat-stress-responsive nuclear genes.

Wang Y, Chang H, Hu S, Lu X, Yuan C, Zhang C, Wang P, Xiao W, Xiao L, Xue GP, Guo X.

J Exp Bot. 2014 Aug;65(15):4159-75. doi: 10.1093/jxb/eru190. Epub 2014 May 6. Erratum in: J Exp Bot. 2017 Mar 1;68(7):1811-1812.


DNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulation.

Kotula E, Faigle W, Berthault N, Dingli F, Loew D, Sun JS, Dutreix M, Quanz M.

PLoS One. 2013 Nov 25;8(11):e80313. doi: 10.1371/journal.pone.0080313. eCollection 2013.


Regulation of molecular chaperones through post-translational modifications: decrypting the chaperone code.

Cloutier P, Coulombe B.

Biochim Biophys Acta. 2013 May;1829(5):443-54. doi: 10.1016/j.bbagrm.2013.02.010. Epub 2013 Feb 28. Review.


Hsp90, an unlikely ally in the war on cancer.

Barrott JJ, Haystead TA.

FEBS J. 2013 Mar;280(6):1381-96. doi: 10.1111/febs.12147. Epub 2013 Feb 24. Review.


An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells.

Muñoz DP, Kawahara M, Yannone SM.

Nucleic Acids Res. 2013 Mar 1;41(5):2894-906. doi: 10.1093/nar/gks1478. Epub 2013 Jan 15.


Safety control for apoptotic irreversibility.

Dutreix M.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12844-5. doi: 10.1073/pnas.1210736109. Epub 2012 Jul 24. No abstract available.


Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy.

Alarcon SV, Mollapour M, Lee MJ, Tsutsumi S, Lee S, Kim YS, Prince T, Apolo AB, Giaccone G, Xu W, Neckers LM, Trepel JB.

Curr Mol Med. 2012 Nov 1;12(9):1125-41. Review.


Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response.

Solier S, Kohn KW, Scroggins B, Xu W, Trepel J, Neckers L, Pommier Y.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12866-72. doi: 10.1073/pnas.1203617109. Epub 2012 Jul 2.


Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci.

Quanz M, Herbette A, Sayarath M, de Koning L, Dubois T, Sun JS, Dutreix M.

J Biol Chem. 2012 Mar 16;287(12):8803-15. doi: 10.1074/jbc.M111.320887. Epub 2012 Jan 23.


Post-translational modifications of Hsp90 and their contributions to chaperone regulation.

Mollapour M, Neckers L.

Biochim Biophys Acta. 2012 Mar;1823(3):648-55. doi: 10.1016/j.bbamcr.2011.07.018. Epub 2011 Aug 10. Review.

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