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Items: 1 to 20 of 48


Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain.

Ji QQ, Fang ZP, Ye Q, Chi CW, Wang ED.

Nucleic Acids Res. 2017 Jul 7;45(12):7367-7381. doi: 10.1093/nar/gkx487.


Acetylation of lysine ϵ-amino groups regulates aminoacyl-tRNA synthetase activity in Escherichia coli.

Ye Q, Ji QQ, Yan W, Yang F, Wang ED.

J Biol Chem. 2017 Jun 23;292(25):10709-10722. doi: 10.1074/jbc.M116.770826. Epub 2017 Apr 28.


The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities.

Zhang Y, Gao B, Zheng F, Lu S, Li Y, Xiong Y, Yang Q, Yang Y, Fu P, Xiao F, Wang X.

Front Mol Neurosci. 2017 Apr 7;10:100. doi: 10.3389/fnmol.2017.00100. eCollection 2017.


Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.

Chopra S, Palencia A, Virus C, Schulwitz S, Temple BR, Cusack S, Reader J.

Nat Commun. 2016 Oct 7;7:12928. doi: 10.1038/ncomms12928.


Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair.

Sun L, Gomes AC, He W, Zhou H, Wang X, Pan DW, Schimmel P, Pan T, Yang XL.

J Am Chem Soc. 2016 Oct 5;138(39):12948-12955. Epub 2016 Sep 26.


Translational Quality Control by Bacterial Threonyl-tRNA Synthetases.

Zhou XL, Chen Y, Fang ZP, Ruan ZR, Wang Y, Liu RJ, Xue MQ, Wang ED.

J Biol Chem. 2016 Sep 30;291(40):21208-21221. Epub 2016 Aug 19.


Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.

Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6271-80. doi: 10.1128/AAC.01339-16. Print 2016 Oct.


Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.

Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5817-27. doi: 10.1128/AAC.00873-16. Print 2016 Oct.


Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.

Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4886-95. doi: 10.1128/AAC.00820-16. Print 2016 Aug.


Elongation Factor Tu Prevents Misediting of Gly-tRNA(Gly) Caused by the Design Behind the Chiral Proofreading Site of D-Aminoacyl-tRNA Deacylase.

Routh SB, Pawar KI, Ahmad S, Singh S, Suma K, Kumar M, Kuncha SK, Yadav K, Kruparani SP, Sankaranarayanan R.

PLoS Biol. 2016 May 25;14(5):e1002465. doi: 10.1371/journal.pbio.1002465. eCollection 2016 May.


Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations.

Perli E, Fiorillo A, Giordano C, Pisano A, Montanari A, Grazioli P, Campese AF, Di Micco P, Tuppen HA, Genovese I, Poser E, Preziuso C, Taylor RW, Morea V, Colotti G, d'Amati G.

Hum Mol Genet. 2016 Mar 1;25(5):903-15. doi: 10.1093/hmg/ddv619. Epub 2015 Dec 31.


First independent replication of the involvement of LARS2 in Perrault syndrome by whole-exome sequencing of an Italian family.

Soldà G, Caccia S, Robusto M, Chiereghin C, Castorina P, Ambrosetti U, Duga S, Asselta R.

J Hum Genet. 2016 Apr;61(4):295-300. doi: 10.1038/jhg.2015.149. Epub 2015 Dec 10.


Temperature dependent mistranslation in a hyperthermophile adapts proteins to lower temperatures.

Schwartz MH, Pan T.

Nucleic Acids Res. 2016 Jan 8;44(1):294-303. doi: 10.1093/nar/gkv1379. Epub 2015 Dec 10.


LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure.

Riley LG, Rudinger-Thirion J, Schmitz-Abe K, Thorburn DR, Davis RL, Teo J, Arbuckle S, Cooper ST, Campagna DR, Frugier M, Markianos K, Sue CM, Fleming MD, Christodoulou J.

JIMD Rep. 2016;28:49-57. Epub 2015 Nov 5.


Trans-oligomerization of duplicated aminoacyl-tRNA synthetases maintains genetic code fidelity under stress.

Rubio MÁ, Napolitano M, Ochoa de Alda JA, Santamaría-Gómez J, Patterson CJ, Foster AW, Bru-Martínez R, Robinson NJ, Luque I.

Nucleic Acids Res. 2015 Nov 16;43(20):9905-17. doi: 10.1093/nar/gkv1020. Epub 2015 Oct 12.


SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis.

Wang C, Guo Y, Tian Q, Jia Q, Gao Y, Zhang Q, Zhou C, Xie W.

Nucleic Acids Res. 2015 Dec 2;43(21):10534-45. doi: 10.1093/nar/gkv996. Epub 2015 Oct 3.


EF-Tu dynamics during pre-translocation complex formation: EF-Tu·GDP exits the ribosome via two different pathways.

Liu W, Chen C, Kavaliauskas D, Knudsen CR, Goldman YE, Cooperman BS.

Nucleic Acids Res. 2015 Oct 30;43(19):9519-28. doi: 10.1093/nar/gkv856. Epub 2015 Sep 3.


Degenerate connective polypeptide 1 (CP1) domain from human mitochondrial leucyl-tRNA synthetase.

Ye Q, Wang M, Fang ZP, Ruan ZR, Ji QQ, Zhou XL, Wang ED.

J Biol Chem. 2015 Oct 2;290(40):24391-402. doi: 10.1074/jbc.M115.672824. Epub 2015 Aug 13.


A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.

Koh CY, Siddaramaiah LK, Ranade RM, Nguyen J, Jian T, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG.

Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1684-98. doi: 10.1107/S1399004715007683. Epub 2015 Jul 31.


MD Simulations of tRNA and Aminoacyl-tRNA Synthetases: Dynamics, Folding, Binding, and Allostery.

Li R, Macnamara LM, Leuchter JD, Alexander RW, Cho SS.

Int J Mol Sci. 2015 Jul 13;16(7):15872-902. doi: 10.3390/ijms160715872. Review.

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