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SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.

Daddacha W, Koyen AE, Bastien AJ, Head PE, Dhere VR, Nabeta GN, Connolly EC, Werner E, Madden MZ, Daly MB, Minten EV, Whelan DR, Schlafstein AJ, Zhang H, Anand R, Doronio C, Withers AE, Shepard C, Sundaram RK, Deng X, Dynan WS, Wang Y, Bindra RS, Cejka P, Rothenberg E, Doetsch PW, Kim B, Yu DS.

Cell Rep. 2017 Aug 22;20(8):1921-1935. doi: 10.1016/j.celrep.2017.08.008.


A CRISPR/Cas9 approach reveals that the polymerase activity of DNA polymerase β is dispensable for HIV-1 infection in dividing and nondividing cells.

Goetze RW, Kim DH, Schinazi RF, Kim B.

J Biol Chem. 2017 Aug 25;292(34):14016-14025. doi: 10.1074/jbc.M117.793661. Epub 2017 Jul 6.


Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2729-2734. doi: 10.1073/pnas.1613635114. Epub 2017 Feb 22.


SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.

Ordonez P, Kunzelmann S, Groom HC, Yap MW, Weising S, Meier C, Bishop KN, Taylor IA, Stoye JP.

Sci Rep. 2017 Feb 21;7:42824. doi: 10.1038/srep42824.


Substrates and Inhibitors of SAMHD1.

Hollenbaugh JA, Shelton J, Tao S, Amiralaei S, Liu P, Lu X, Goetze RW, Zhou L, Nettles JH, Schinazi RF, Kim B.

PLoS One. 2017 Jan 3;12(1):e0169052. doi: 10.1371/journal.pone.0169052. eCollection 2017.


A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.

Bloch N, Gläsker S, Sitaram P, Hofmann H, Shepard CN, Schultz ML, Kim B, Landau NR.

J Biol Chem. 2017 Jan 20;292(3):1068-1080. doi: 10.1074/jbc.M116.743740. Epub 2016 Dec 5.


Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.

Riess M, Fuchs NV, Idica A, Hamdorf M, Flory E, Pedersen IM, König R.

J Biol Chem. 2017 Jan 6;292(1):264-277. doi: 10.1074/jbc.M116.752584. Epub 2016 Dec 1.


Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.

Bhattacharya A, Wang Z, White T, Buffone C, Nguyen LA, Shepard CN, Kim B, Demeler B, Diaz-Griffero F, Ivanov DN.

Sci Rep. 2016 Aug 11;6:31353. doi: 10.1038/srep31353.


Modulation of LINE-1 Retrotransposition by a Human SAMHD1 Polymorphism.

White TE, Brandariz-Nuñez A, Han K, Sawyer SL, Kim B, Diaz-Griffero F.

Virol Rep. 2016 Dec;6:53-60.


SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells.

Bonifati S, Daly MB, St Gelais C, Kim SH, Hollenbaugh JA, Shepard C, Kennedy EM, Kim DH, Schinazi RF, Kim B, Wu L.

Virology. 2016 Aug;495:92-100. doi: 10.1016/j.virol.2016.05.002. Epub 2016 May 14.


Dual anti-HIV mechanism of clofarabine.

Daly MB, Roth ME, Bonnac L, Maldonado JO, Xie J, Clouser CL, Patterson SE, Kim B, Mansky LM.

Retrovirology. 2016 Mar 24;13:20. doi: 10.1186/s12977-016-0254-0.


Commentary: MARCH8 Inhibits HIV-1 Infection by Reducing Virion Incorporation of Envelope Glycoproteins.

Fujita M.

Front Microbiol. 2016 Feb 24;7:254. doi: 10.3389/fmicb.2016.00254. eCollection 2016. No abstract available.


SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load.

Buchanan EL, Espinoza DA, McAlexander MA, Myers SL, Moyer A, Witwer KW.

Sci Rep. 2016 Mar 3;6:22629. doi: 10.1038/srep22629.


Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages.

Hollenbaugh JA, Montero C, Schinazi RF, Munger J, Kim B.

Virology. 2016 Apr;491:106-14. doi: 10.1016/j.virol.2016.01.023. Epub 2016 Feb 16.


Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1.

Welbourn S, Strebel K.

Virology. 2016 Jan 15;488:271-7. doi: 10.1016/j.virol.2015.11.022. Epub 2015 Dec 4.


Fluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus.

Desai TM, Marin M, Sood C, Shi J, Nawaz F, Aiken C, Melikyan GB.

Retrovirology. 2015 Oct 29;12:88. doi: 10.1186/s12977-015-0215-z.


The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.

Nguyen XN, Barateau V, Wu N, Berger G, Cimarelli A.

PLoS One. 2015 Oct 23;10(10):e0140561. doi: 10.1371/journal.pone.0140561. eCollection 2015.


Structural Insights into the High-efficiency Catalytic Mechanism of the Sterile α-Motif/Histidine-Aspartate Domain-containing Protein.

Li Y, Kong J, Peng X, Hou W, Qin X, Yu XF.

J Biol Chem. 2015 Dec 4;290(49):29428-37. doi: 10.1074/jbc.M115.663658. Epub 2015 Oct 5.

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