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Items: 19


Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly.

Wang H, Guo H, Su J, Rui Y, Zheng W, Gao W, Zhang W, Li Z, Liu G, Markham RB, Wei W, Yu XF.

J Virol. 2017 Apr 13;91(9). pii: e00225-17. doi: 10.1128/JVI.00225-17. Print 2017 May 1.


Structural Basis of Clade-specific Engagement of SAMHD1 (Sterile α Motif and Histidine/Aspartate-containing Protein 1) Restriction Factors by Lentiviral Viral Protein X (Vpx) Virulence Factors.

Wu Y, Koharudin LM, Mehrens J, DeLucia M, Byeon CH, Byeon IJ, Calero G, Ahn J, Gronenborn AM.

J Biol Chem. 2015 Jul 17;290(29):17935-45. doi: 10.1074/jbc.M115.665513. Epub 2015 Jun 4.


The susceptibility of primate lentiviruses to nucleosides and Vpx during infection of dendritic cells is regulated by CA.

Barateau V, Nguyen XN, Bourguillault F, Berger G, Cordeil S, Cimarelli A.

J Virol. 2015 Apr;89(7):4030-4. doi: 10.1128/JVI.03315-14. Epub 2015 Jan 21.


Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.

White TE, Brandariz-Nuñez A, Valle-Casuso JC, Knowlton C, Kim B, Sawyer SL, Diaz-Griffero F.

Virology. 2014 Jul;460-461:34-44. doi: 10.1016/j.virol.2014.04.023. Epub 2014 May 29.


Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1.

Brandariz-Nuñez A, Valle-Casuso JC, White TE, Nguyen L, Bhattacharya A, Wang Z, Demeler B, Amie S, Knowlton C, Kim B, Ivanov DN, Diaz-Griffero F.

Retrovirology. 2013 Nov 12;10:131. doi: 10.1186/1742-4690-10-131.


Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins.

Wei W, Guo H, Gao Q, Markham R, Yu XF.

J Virol. 2014 Jan;88(1):583-91. doi: 10.1128/JVI.02866-13. Epub 2013 Oct 30.


Non-simian foamy viruses: molecular virology, tropism and prevalence and zoonotic/interspecies transmission.

Kehl T, Tan J, Materniak M.

Viruses. 2013 Sep 13;5(9):2169-209. doi: 10.3390/v5092169. Review.


SAMHD1-dependent retroviral control and escape in mice.

Rehwinkel J, Maelfait J, Bridgeman A, Rigby R, Hayward B, Liberatore RA, Bieniasz PD, Towers GJ, Moita LF, Crow YJ, Bonthron DT, Reis e Sousa C.

EMBO J. 2013 Sep 11;32(18):2454-62. doi: 10.1038/emboj.2013.163. Epub 2013 Jul 19.


Gene loss and adaptation to hominids underlie the ancient origin of HIV-1.

Etienne L, Hahn BH, Sharp PM, Matsen FA, Emerman M.

Cell Host Microbe. 2013 Jul 17;14(1):85-92. doi: 10.1016/j.chom.2013.06.002.


HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation.

DeLucia M, Mehrens J, Wu Y, Ahn J.

J Biol Chem. 2013 Jun 28;288(26):19116-26. doi: 10.1074/jbc.M113.469007. Epub 2013 May 15.


The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation.

White TE, Brandariz-Nuñez A, Valle-Casuso JC, Amie S, Nguyen LA, Kim B, Tuzova M, Diaz-Griffero F.

Cell Host Microbe. 2013 Apr 17;13(4):441-51. doi: 10.1016/j.chom.2013.03.005.


The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals.

Yu H, Usmani SM, Borch A, Krämer J, Stürzel CM, Khalid M, Li X, Krnavek D, van der Ende ME, Osterhaus AD, Gruters RA, Kirchhoff F.

Retrovirology. 2013 Mar 5;10:27. doi: 10.1186/1742-4690-10-27.


Breaking Barriers to an AIDS Model with Macaque-Tropic HIV-1 Derivatives.

Thippeshappa R, Ruan H, Kimata JT.

Biology (Basel). 2012 May 12;1(2):134-64. doi: 10.3390/biology1020134.


SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons.

St Gelais C, de Silva S, Amie SM, Coleman CM, Hoy H, Hollenbaugh JA, Kim B, Wu L.

Retrovirology. 2012 Dec 11;9:105. doi: 10.1186/1742-4690-9-105.


Evolutionary dynamics of the interferon-induced transmembrane gene family in vertebrates.

Zhang Z, Liu J, Li M, Yang H, Zhang C.

PLoS One. 2012;7(11):e49265. doi: 10.1371/journal.pone.0049265. Epub 2012 Nov 15.


Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.

White TE, Brandariz-Nuñez A, Valle-Casuso JC, Amie S, Nguyen L, Kim B, Brojatsch J, Diaz-Griffero F.

Virology. 2013 Feb 5;436(1):81-90. doi: 10.1016/j.virol.2012.10.029. Epub 2012 Nov 13.


The restriction factors of human immunodeficiency virus.

Harris RS, Hultquist JF, Evans DT.

J Biol Chem. 2012 Nov 30;287(49):40875-83. doi: 10.1074/jbc.R112.416925. Epub 2012 Oct 5. Review.


Macrophages and their relevance in Human Immunodeficiency Virus Type I infection.

Koppensteiner H, Brack-Werner R, Schindler M.

Retrovirology. 2012 Oct 4;9:82. doi: 10.1186/1742-4690-9-82. Review.

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