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Items: 1 to 20 of 106


Regulation of amino-acid metabolism controls flux to lipid accumulation in Yarrowia lipolytica.

Kerkhoven EJ, Pomraning KR, Baker SE, Nielsen J.

NPJ Syst Biol Appl. 2016 Mar 3;2:16005. doi: 10.1038/npjsba.2016.5. eCollection 2016.


Leucine Biosynthesis Is Involved in Regulating High Lipid Accumulation in Yarrowia lipolytica.

Kerkhoven EJ, Kim YM, Wei S, Nicora CD, Fillmore TL, Purvine SO, Webb-Robertson BJ, Smith RD, Baker SE, Metz TO, Nielsen J.

MBio. 2017 Jun 20;8(3). pii: e00857-17. doi: 10.1128/mBio.00857-17.


The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability.

Wilms T, Swinnen E, Eskes E, Dolz-Edo L, Uwineza A, Van Essche R, Rosseels J, Zabrocki P, Cameroni E, Franssens V, De Virgilio C, Smits GJ, Winderickx J.

PLoS Genet. 2017 Jun 12;13(6):e1006835. doi: 10.1371/journal.pgen.1006835. eCollection 2017 Jun.


Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition.

Liu NN, Flanagan PR, Zeng J, Jani NM, Cardenas ME, Moran GP, Köhler JR.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6346-6351. doi: 10.1073/pnas.1617799114. Epub 2017 May 31.


General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae.

Yuan W, Guo S, Gao J, Zhong M, Yan G, Wu W, Chao Y, Jiang Y.

J Biol Chem. 2017 Feb 17;292(7):2660-2669. doi: 10.1074/jbc.M116.772194. Epub 2017 Jan 5.


General Amino Acid Control and 14-3-3 Proteins Bmh1/2 Are Required for Nitrogen Catabolite Repression-Sensitive Regulation of Gln3 and Gat1 Localization.

Tate JJ, Buford D, Rai R, Cooper TG.

Genetics. 2017 Feb;205(2):633-655. doi: 10.1534/genetics.116.195800. Epub 2016 Dec 22.


Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.

Sun L, Song Y, Blocquel D, Yang XL, Schimmel P.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14300-14305. Epub 2016 Nov 28.


Proliferating Helper T Cells Require Rictor/mTORC2 Complex to Integrate Signals from Limiting Environmental Amino Acids.

Van de Velde LA, Murray PJ.

J Biol Chem. 2016 Dec 9;291(50):25815-25822. Epub 2016 Oct 31.


mTORC1 and mTORC2 in cancer and the tumor microenvironment.

Kim LC, Cook RS, Chen J.

Oncogene. 2017 Apr 20;36(16):2191-2201. doi: 10.1038/onc.2016.363. Epub 2016 Oct 17. Review.


Experimental approaches for investigation of aminoacyl tRNA synthetase phosphorylation.

Arif A, Jia J, Halawani D, Fox PL.

Methods. 2017 Jan 15;113:72-82. doi: 10.1016/j.ymeth.2016.10.004. Epub 2016 Oct 8. Review.


Dynamics of mTORC1 activation in response to amino acids.

Manifava M, Smith M, Rotondo S, Walker S, Niewczas I, Zoncu R, Clark J, Ktistakis NT.

Elife. 2016 Oct 11;5. pii: e19960. doi: 10.7554/eLife.19960.


Recent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1.

Zheng L, Zhang W, Zhou Y, Li F, Wei H, Peng J.

Int J Mol Sci. 2016 Sep 29;17(10). pii: E1636. Review.


Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting.

Semba RD, Trehan I, Gonzalez-Freire M, Kraemer K, Moaddel R, Ordiz MI, Ferrucci L, Manary MJ.

Adv Nutr. 2016 Sep 15;7(5):853-65. doi: 10.3945/an.116.013276. Print 2016 Sep.


The lysosome as a command-and-control center for cellular metabolism.

Lim CY, Zoncu R.

J Cell Biol. 2016 Sep 12;214(6):653-64. doi: 10.1083/jcb.201607005. Review.


Rags to riches: Amino acid sensing by the Rag GTPases in health and disease.

Brady OA, Diab HI, Puertollano R.

Small GTPases. 2016 Oct;7(4):197-206. Epub 2016 Aug 31.


The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance.

Yoon MS, Choi CS.

Exp Mol Med. 2016 Jan 8;48(1):e201. doi: 10.1038/emm.2015.93. Review.


Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling.

Yoon MS, Son K, Arauz E, Han JM, Kim S, Chen J.

Cell Rep. 2016 Aug 9;16(6):1510-7. doi: 10.1016/j.celrep.2016.07.008. Epub 2016 Jul 28.


Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling.

Powis K, De Virgilio C.

Cell Discov. 2016 Mar 8;2:15049. doi: 10.1038/celldisc.2015.49. eCollection 2016. Review.


Unsolved mysteries of Rag GTPase signaling in yeast.

Hatakeyama R, De Virgilio C.

Small GTPases. 2016 Oct;7(4):239-246. Epub 2016 Jul 11.


Sub-Cellular Localization and Complex Formation by Aminoacyl-tRNA Synthetases in Cyanobacteria: Evidence for Interaction of Membrane-Anchored ValRS with ATP Synthase.

Santamaría-Gómez J, Ochoa de Alda JA, Olmedo-Verd E, Bru-Martínez R, Luque I.

Front Microbiol. 2016 Jun 6;7:857. doi: 10.3389/fmicb.2016.00857. eCollection 2016.

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