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Items: 1 to 20 of 92


Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets.

Maciejewski M, Lounkine E, Whitebread S, Farmer P, DuMouchel W, Shoichet BK, Urban L.

Elife. 2017 Aug 8;6. pii: e25818. doi: 10.7554/eLife.25818.


Data-driven prediction of adverse drug reactions induced by drug-drug interactions.

Liu R, AbdulHameed MDM, Kumar K, Yu X, Wallqvist A, Reifman J.

BMC Pharmacol Toxicol. 2017 Jun 8;18(1):44. doi: 10.1186/s40360-017-0153-6.


Characterization of the mechanism of drug-drug interactions from PubMed using MeSH terms.

Lu Y, Figler B, Huang H, Tu YC, Wang J, Cheng F.

PLoS One. 2017 Apr 19;12(4):e0173548. doi: 10.1371/journal.pone.0173548. eCollection 2017.


Data-Driven Prediction of Beneficial Drug Combinations in Spontaneous Reporting Systems.

Li Y, Zhang P, Sun Z, Hu J.

AMIA Annu Symp Proc. 2017 Feb 10;2016:808-817. eCollection 2016.


Positive-Unlabeled Learning for inferring drug interactions based on heterogeneous attributes.

Hameed PN, Verspoor K, Kusljic S, Halgamuge S.

BMC Bioinformatics. 2017 Mar 1;18(1):140. doi: 10.1186/s12859-017-1546-7.


Drug voyager: a computational platform for exploring unintended drug action.

Oh M, Ahn J, Lee T, Jang G, Park C, Yoon Y.

BMC Bioinformatics. 2017 Feb 28;18(1):131. doi: 10.1186/s12859-017-1558-3.


Biomedical Informatics Approaches to Identifying Drug-Drug Interactions: Application to Insulin Secretagogues.

Han X, Chiang C, Leonard CE, Bilker WB, Brensinger CM, Li L, Hennessy S.

Epidemiology. 2017 May;28(3):459-468. doi: 10.1097/EDE.0000000000000638.


Predicting potential drug-drug interactions by integrating chemical, biological, phenotypic and network data.

Zhang W, Chen Y, Liu F, Luo F, Tian G, Li X.

BMC Bioinformatics. 2017 Jan 5;18(1):18. doi: 10.1186/s12859-016-1415-9.


Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation.

Lorberbaum T, Sampson KJ, Chang JB, Iyer V, Woosley RL, Kass RS, Tatonetti NP.

J Am Coll Cardiol. 2016 Oct 18;68(16):1756-1764. doi: 10.1016/j.jacc.2016.07.761.


MeSHDD: Literature-based drug-drug similarity for drug repositioning.

Brown AS, Patel CJ.

J Am Med Inform Assoc. 2017 May 1;24(3):614-618. doi: 10.1093/jamia/ocw142.


Big Data Mining and Adverse Event Pattern Analysis in Clinical Drug Trials.

Federer C, Yoo M, Tan AC.

Assay Drug Dev Technol. 2016 Dec;14(10):557-566. Epub 2016 Sep 15.


Clustering drug-drug interaction networks with energy model layouts: community analysis and drug repurposing.

Udrescu L, Sbârcea L, Topîrceanu A, Iovanovici A, Kurunczi L, Bogdan P, Udrescu M.

Sci Rep. 2016 Sep 7;6:32745. doi: 10.1038/srep32745.


Clinical phenotyping in selected national networks: demonstrating the need for high-throughput, portable, and computational methods.

Richesson RL, Sun J, Pathak J, Kho AN, Denny JC.

Artif Intell Med. 2016 Jul;71:57-61. doi: 10.1016/j.artmed.2016.05.005. Epub 2016 Jun 25.


Patient-Level Adverse Event Patterns in a Single-Institution Study of the Multi-Kinase Inhibitor Sorafenib.

Karovic S, Shiuan EF, Zhang SQ, Cao H, Maitland ML.

Clin Transl Sci. 2016 Jul 21. doi: 10.1111/cts.12408. [Epub ahead of print]


Laboratory tests as short-term correlates of stroke.

Sughrue T, Swiernik MA, Huang Y, Brody JP.

BMC Neurol. 2016 Jul 21;16:112. doi: 10.1186/s12883-016-0619-y.


A curated and standardized adverse drug event resource to accelerate drug safety research.

Banda JM, Evans L, Vanguri RS, Tatonetti NP, Ryan PB, Shah NH.

Sci Data. 2016 May 10;3:160026. doi: 10.1038/sdata.2016.26.


Deep Patient: An Unsupervised Representation to Predict the Future of Patients from the Electronic Health Records.

Miotto R, Li L, Kidd BA, Dudley JT.

Sci Rep. 2016 May 17;6:26094. doi: 10.1038/srep26094.


Drug-induced adverse events prediction with the LINCS L1000 data.

Wang Z, Clark NR, Ma'ayan A.

Bioinformatics. 2016 Aug 1;32(15):2338-45. doi: 10.1093/bioinformatics/btw168. Epub 2016 Apr 1.


In silico methods for drug repurposing and pharmacology.

Hodos RA, Kidd BA, Shameer K, Readhead BP, Dudley JT.

Wiley Interdiscip Rev Syst Biol Med. 2016 May;8(3):186-210. doi: 10.1002/wsbm.1337. Epub 2016 Apr 15. Review.

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