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Items: 1 to 20 of 39

1.

Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry.

Borrenberghs D, Dirix L, De Wit F, Rocha S, Blokken J, De Houwer S, Gijsbers R, Christ F, Hofkens J, Hendrix J, Debyser Z.

Sci Rep. 2016 Nov 10;6:36485. doi: 10.1038/srep36485.

2.

Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras.

Vranckx LS, Demeulemeester J, Debyser Z, Gijsbers R.

PLoS One. 2016 Oct 27;11(10):e0164167. doi: 10.1371/journal.pone.0164167.

3.

LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV.

Vranckx LS, Demeulemeester J, Saleh S, Boll A, Vansant G, Schrijvers R, Weydert C, Battivelli E, Verdin E, Cereseto A, Christ F, Gijsbers R, Debyser Z.

EBioMedicine. 2016 Jun;8:248-64. doi: 10.1016/j.ebiom.2016.04.039.

4.

The Structure-Specific Recognition Protein 1 Associates with Lens Epithelium-Derived Growth Factor Proteins and Modulates HIV-1 Replication.

Lopez AP, Kugelman JR, Garcia-Rivera J, Urias E, Salinas SA, Fernandez-Zapico ME, Llano M.

J Mol Biol. 2016 Jul 17;428(14):2814-31. doi: 10.1016/j.jmb.2016.05.013.

PMID:
27216501
5.

Retroviral DNA Integration.

Lesbats P, Engelman AN, Cherepanov P.

Chem Rev. 2016 May 20. [Epub ahead of print]

6.

The Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFIm) Complex Mediates HIV-1 Integration into Genes.

Rasheedi S, Shun MC, Serrao E, Sowd GA, Qian J, Hao C, Dasgupta T, Engelman AN, Skowronski J.

J Biol Chem. 2016 May 27;291(22):11809-19. doi: 10.1074/jbc.M116.721647.

PMID:
26994143
7.

Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions.

Quercioli V, Di Primio C, Casini A, Mulder LC, Vranckx LS, Borrenberghs D, Gijsbers R, Debyser Z, Cereseto A.

J Virol. 2016 Apr 29;90(10):5205-9. doi: 10.1128/JVI.03188-15.

8.

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.

Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1054-63. doi: 10.1073/pnas.1524213113.

9.

Sites of retroviral DNA integration: From basic research to clinical applications.

Serrao E, Engelman AN.

Crit Rev Biochem Mol Biol. 2016;51(1):26-42. doi: 10.3109/10409238.2015.1102859. Review.

10.

Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection.

Demeulemeester J, De Rijck J, Gijsbers R, Debyser Z.

Bioessays. 2015 Nov;37(11):1202-14. doi: 10.1002/bies.201500051. Review.

11.

Host Factors in Retroviral Integration and the Selection of Integration Target Sites.

Craigie R, Bushman FD.

Microbiol Spectr. 2014 Dec;2(6). doi: 10.1128/microbiolspec.MDNA3-0026-2014. Review.

12.

DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity.

Naughtin M, Haftek-Terreau Z, Xavier J, Meyer S, Silvain M, Jaszczyszyn Y, Levy N, Miele V, Benleulmi MS, Ruff M, Parissi V, Vaillant C, Lavigne M.

PLoS One. 2015 Jun 15;10(6):e0129427. doi: 10.1371/journal.pone.0129427.

13.

Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor.

Quashie PK, Han YS, Hassounah S, Mespl├Ęde T, Wainberg MA.

PLoS One. 2015 Jun 5;10(6):e0128310. doi: 10.1371/journal.pone.0128310.

14.

Key determinants of target DNA recognition by retroviral intasomes.

Serrao E, Ballandras-Colas A, Cherepanov P, Maertens GN, Engelman AN.

Retrovirology. 2015 Apr 30;12:39. doi: 10.1186/s12977-015-0167-3.

15.

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.

Desimmie BA, Weydert C, Schrijvers R, Vets S, Demeulemeester J, Proost P, Paron I, De Rijck J, Mast J, Bannert N, Gijsbers R, Christ F, Debyser Z.

Retrovirology. 2015 Feb 12;12:16. doi: 10.1186/s12977-014-0134-4.

16.

HIV-1 integrase multimerization as a therapeutic target.

Feng L, Larue RC, Slaughter A, Kessl JJ, Kvaratskhelia M.

Curr Top Microbiol Immunol. 2015;389:93-119. doi: 10.1007/82_2015_439. Review.

17.

Understanding HIV latency: the road to an HIV cure.

Dahabieh MS, Battivelli E, Verdin E.

Annu Rev Med. 2015;66:407-21. doi: 10.1146/annurev-med-092112-152941. Review.

18.

Human immunodeficiency virus (HIV)-1 integration sites in viral latency.

Rezaei SD, Cameron PU.

Curr HIV/AIDS Rep. 2015 Mar;12(1):88-96. doi: 10.1007/s11904-014-0241-9. Review.

19.

Molecular mechanisms of retroviral integration site selection.

Kvaratskhelia M, Sharma A, Larue RC, Serrao E, Engelman A.

Nucleic Acids Res. 2014;42(16):10209-25. doi: 10.1093/nar/gku769.

20.

BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements.

El Ashkar S, De Rijck J, Demeulemeester J, Vets S, Madlala P, Cermakova K, Debyser Z, Gijsbers R.

Mol Ther Nucleic Acids. 2014 Jul 29;3:e179. doi: 10.1038/mtna.2014.33.

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