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Items: 1 to 20 of 275

1.

Radiation-induced translational control of gene expression.

Wahba A, Lehman SL, Tofilon PJ.

Translation (Austin). 2016 Dec 1;5(1):e1265703. doi: 10.1080/21690731.2016.1265703. eCollection 2017. Review.

PMID:
28702276
2.

LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs.

Hong S, Freeberg MA, Han T, Kamath A, Yao Y, Fukuda T, Suzuki T, Kim JK, Inoki K.

Elife. 2017 Jun 26;6. pii: e25237. doi: 10.7554/eLife.25237.

3.

Systematic genomic and translational efficiency studies of uveal melanoma.

Johnson CP, Kim IK, Esmaeli B, Amin-Mansour A, Treacy DJ, Carter SL, Hodis E, Wagle N, Seepo S, Yu X, Lane AM, Gragoudas ES, Vazquez F, Nickerson E, Cibulskis K, McKenna A, Gabriel SB, Getz G, Van Allen EM, 't Hoen PAC, Garraway LA, Woodman SE.

PLoS One. 2017 Jun 8;12(6):e0178189. doi: 10.1371/journal.pone.0178189. eCollection 2017.

4.

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs.

Lahr RM, Fonseca BD, Ciotti GE, Al-Ashtal HA, Jia JJ, Niklaus MR, Blagden SP, Alain T, Berman AJ.

Elife. 2017 Apr 7;6. pii: e24146. doi: 10.7554/eLife.24146.

5.

PI3K signaling in cancer: beyond AKT.

Lien EC, Dibble CC, Toker A.

Curr Opin Cell Biol. 2017 Apr;45:62-71. doi: 10.1016/j.ceb.2017.02.007. Epub 2017 Mar 24. Review.

PMID:
28343126
6.

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate JH.

PLoS Biol. 2017 Mar 21;15(3):e2001882. doi: 10.1371/journal.pbio.2001882. eCollection 2017 Mar.

7.

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.

Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA.

Cancer Cell. 2017 Mar 13;31(3):424-435. doi: 10.1016/j.ccell.2017.01.014.

PMID:
28292440
8.

mTOR Signaling in Growth, Metabolism, and Disease.

Saxton RA, Sabatini DM.

Cell. 2017 Mar 9;168(6):960-976. doi: 10.1016/j.cell.2017.02.004. Review.

PMID:
28283069
9.

Human eIF3: from 'blobology' to biological insight.

Cate JH.

Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19;372(1716). pii: 20160176. doi: 10.1098/rstb.2016.0176. Review.

10.

The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma.

Burwick N, Zhang MY, de la Puente P, Azab AK, Hyun TS, Ruiz-Gutierrez M, Sanchez-Bonilla M, Nakamura T, Delrow JJ, MacKay VL, Shimamura A.

Leuk Res. 2017 Apr;55:23-32. doi: 10.1016/j.leukres.2017.01.007. Epub 2017 Jan 12.

PMID:
28119225
11.

Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion.

Chen W, Lu N, Ding Y, Wang Y, Chan LT, Wang X, Gao X, Jiang S, Liu K.

eNeuro. 2017 Jan 13;3(6). pii: ENEURO.0358-16.2016. doi: 10.1523/ENEURO.0358-16.2016. eCollection 2016 Nov-Dec.

12.

Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation.

Ostroff LE, Botsford B, Gindina S, Cowansage KK, LeDoux JE, Klann E, Hoeffer C.

J Neurosci. 2017 Feb 15;37(7):1862-1872. doi: 10.1523/JNEUROSCI.3301-16.2017. Epub 2017 Jan 13.

PMID:
28087764
13.

AR-Signaling in Human Malignancies: Prostate Cancer and Beyond.

Schweizer MT, Yu EY.

Cancers (Basel). 2017 Jan 11;9(1). pii: E7. doi: 10.3390/cancers9010007. Review.

14.

Translation from unconventional 5' start sites drives tumour initiation.

Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E.

Nature. 2017 Jan 26;541(7638):494-499. doi: 10.1038/nature21036. Epub 2017 Jan 11.

15.

PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer.

Chen L, Jin T, Zhu K, Piao Y, Quan T, Quan C, Lin Z.

Oncotarget. 2017 Feb 14;8(7):11937-11949. doi: 10.18632/oncotarget.14442.

16.

Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer.

Cao GD, Xu XY, Zhang JW, Chen B, Xiong MM.

PLoS One. 2016 Dec 22;11(12):e0168085. doi: 10.1371/journal.pone.0168085. eCollection 2016.

17.

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

Mateo F, Arenas EJ, Aguilar H, Serra-Musach J, de Garibay GR, Boni J, Maicas M, Du S, Iorio F, Herranz-Ors C, Islam A, Prado X, Llorente A, Petit A, Vidal A, Català I, Soler T, Venturas G, Rojo-Sebastian A, Serra H, Cuadras D, Blanco I, Lozano J, Canals F, Sieuwerts AM, de Weerd V, Look MP, Puertas S, García N, Perkins AS, Bonifaci N, Skowron M, Gómez-Baldó L, Hernández V, Martínez-Aranda A, Martínez-Iniesta M, Serrat X, Cerón J, Brunet J, Barretina MP, Gil M, Falo C, Fernández A, Morilla I, Pernas S, Plà MJ, Andreu X, Seguí MA, Ballester R, Castellà E, Nellist M, Morales S, Valls J, Velasco A, Matias-Guiu X, Figueras A, Sánchez-Mut JV, Sánchez-Céspedes M, Cordero A, Gómez-Miragaya J, Palomero L, Gómez A, Gajewski TF, Cohen EEW, Jesiotr M, Bodnar L, Quintela-Fandino M, López-Bigas N, Valdés-Mas R, Puente XS, Viñals F, Casanovas O, Graupera M, Hernández-Losa J, Ramón Y Cajal S, García-Alonso L, Saez-Rodriguez J, Esteller M, Sierra A, Martín-Martín N, Matheu A, Carracedo A, González-Suárez E, Nanjundan M, Cortés J, Lázaro C, Odero MD, Martens JWM, Moreno-Bueno G, Barcellos-Hoff MH, Villanueva A, Gomis RR, Pujana MA.

Oncogene. 2017 May 11;36(19):2737-2749. doi: 10.1038/onc.2016.427. Epub 2016 Dec 19.

18.

mTORC1 and -2 Coordinate Transcriptional and Translational Reprogramming in Resistance to DNA Damage and Replicative Stress in Breast Cancer Cells.

Silvera D, Ernlund A, Arju R, Connolly E, Volta V, Wang J, Schneider RJ.

Mol Cell Biol. 2017 Feb 15;37(5). pii: e00577-16. doi: 10.1128/MCB.00577-16. Print 2017 Mar 1.

PMID:
27956700
19.

Insights into the mechanisms of eukaryotic translation gained with ribosome profiling.

Andreev DE, O'Connor PB, Loughran G, Dmitriev SE, Baranov PV, Shatsky IN.

Nucleic Acids Res. 2017 Jan 25;45(2):513-526. doi: 10.1093/nar/gkw1190. Epub 2016 Dec 6. Review.

20.

Inhibition of mTOR induces a paused pluripotent state.

Bulut-Karslioglu A, Biechele S, Jin H, Macrae TA, Hejna M, Gertsenstein M, Song JS, Ramalho-Santos M.

Nature. 2016 Dec 1;540(7631):119-123. doi: 10.1038/nature20578. Epub 2016 Nov 23.

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