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Items: 1 to 20 of 300

1.

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.

Willett R, Martina JA, Zewe JP, Wills R, Hammond GRV, Puertollano R.

Nat Commun. 2017 Nov 17;8(1):1580. doi: 10.1038/s41467-017-01871-z.

2.

AAV-mediated transcription factor EB (TFEB) gene delivery ameliorates muscle pathology and function in the murine model of Pompe Disease.

Gatto F, Rossi B, Tarallo A, Polishchuk E, Polishchuk R, Carrella A, Nusco E, Alvino FG, Iacobellis F, De Leonibus E, Auricchio A, Diez-Roux G, Ballabio A, Parenti G.

Sci Rep. 2017 Nov 8;7(1):15089. doi: 10.1038/s41598-017-15352-2.

3.

Hepatic Lipophagy: New Insights into Autophagic Catabolism of Lipid Droplets in the Liver.

Schulze RJ, Drižytė K, Casey CA, McNiven MA.

Hepatol Commun. 2017 Jul;1(5):359-369. doi: 10.1002/hep4.1056. Epub 2017 Jun 9.

PMID:
29109982
4.

Twenty-five years of mTOR: Uncovering the link from nutrients to growth.

Sabatini DM.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11818-11825. doi: 10.1073/pnas.1716173114. Epub 2017 Oct 25.

5.

Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo.

Murano T, Najibi M, Paulus GLC, Adiliaghdam F, Valencia-Guerrero A, Selig M, Wang X, Jeffrey K, Xavier RJ, Lassen KG, Irazoqui JE.

Sci Rep. 2017 Oct 24;7(1):13938. doi: 10.1038/s41598-017-14370-4.

6.

A Skeletal Muscle Model of Infantile-onset Pompe Disease with Patient-specific iPS Cells.

Yoshida T, Awaya T, Jonouchi T, Kimura R, Kimura S, Era T, Heike T, Sakurai H.

Sci Rep. 2017 Oct 18;7(1):13473. doi: 10.1038/s41598-017-14063-y.

7.

Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice.

Singh SR, Zech ATL, Geertz B, Reischmann-Düsener S, Osinska H, Prondzynski M, Krämer E, Meng Q, Redwood C, van der Velden J, Robbins J, Schlossarek S, Carrier L.

Circ Heart Fail. 2017 Oct;10(10). pii: e004140. doi: 10.1161/CIRCHEARTFAILURE.117.004140.

PMID:
29021349
8.

TOR-mediated regulation of metabolism in aging.

Antikainen H, Driscoll M, Haspel G, Dobrowolski R.

Aging Cell. 2017 Dec;16(6):1219-1233. doi: 10.1111/acel.12689. Epub 2017 Oct 2. Review.

9.

Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells.

Tseng HHL, Vong CT, Kwan YW, Lee SM, Hoi MPM.

Front Immunol. 2017 Sep 15;8:1161. doi: 10.3389/fimmu.2017.01161. eCollection 2017.

10.

Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition.

Kim SH, Kim G, Han DH, Lee M, Kim I, Kim B, Kim KH, Song YM, Yoo JE, Wang HJ, Bae SH, Lee YH, Lee BW, Kang ES, Cha BS, Lee MS.

Autophagy. 2017 Oct 3;13(10):1767-1781. doi: 10.1080/15548627.2017.1356977. Epub 2017 Sep 21.

PMID:
28933629
11.

Sinomenine Hydrochloride Inhibits Human Glioblastoma Cell Growth through Reactive Oxygen Species Generation and Autophagy-Lysosome Pathway Activation: An In Vitro and In Vivo Study.

Jiang Y, Jiao Y, Wang Z, Li T, Liu Y, Li Y, Zhao X, Wang D.

Int J Mol Sci. 2017 Sep 11;18(9). pii: E1945. doi: 10.3390/ijms18091945.

12.

Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer.

Englinger B, Kallus S, Senkiv J, Heilos D, Gabler L, van Schoonhoven S, Terenzi A, Moser P, Pirker C, Timelthaler G, Jäger W, Kowol CR, Heffeter P, Grusch M, Berger W.

J Exp Clin Cancer Res. 2017 Sep 7;36(1):122. doi: 10.1186/s13046-017-0592-3.

13.

mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy.

Bartolomeo R, Cinque L, De Leonibus C, Forrester A, Salzano AC, Monfregola J, De Gennaro E, Nusco E, Azario I, Lanzara C, Serafini M, Levine B, Ballabio A, Settembre C.

J Clin Invest. 2017 Oct 2;127(10):3717-3729. doi: 10.1172/JCI94130. Epub 2017 Sep 5.

14.

Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses.

Sirci F, Napolitano F, Pisonero-Vaquero S, Carrella D, Medina DL, di Bernardo D.

NPJ Syst Biol Appl. 2017 Aug 25;3:23. doi: 10.1038/s41540-017-0022-3. eCollection 2017.

15.

Emerging Roles for the Lysosome in Lipid Metabolism.

Thelen AM, Zoncu R.

Trends Cell Biol. 2017 Nov;27(11):833-850. doi: 10.1016/j.tcb.2017.07.006. Epub 2017 Aug 30. Review.

PMID:
28838620
16.

Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA.

Patel S, Ashwanikumar N, Robinson E, DuRoss A, Sun C, Murphy-Benenato KE, Mihai C, Almarsson Ö, Sahay G.

Nano Lett. 2017 Sep 13;17(9):5711-5718. doi: 10.1021/acs.nanolett.7b02664. Epub 2017 Aug 24.

PMID:
28836442
17.

BORC coordinates encounter and fusion of lysosomes with autophagosomes.

Jia R, Guardia CM, Pu J, Chen Y, Bonifacino JS.

Autophagy. 2017 Oct 3;13(10):1648-1663. doi: 10.1080/15548627.2017.1343768. Epub 2017 Aug 21.

18.

Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy.

Neill T, Sharpe C, Owens RT, Iozzo RV.

J Biol Chem. 2017 Sep 29;292(39):16211-16220. doi: 10.1074/jbc.M116.769950. Epub 2017 Aug 10.

19.

Regulation of Rab5 isoforms by transcriptional and post-transcriptional mechanisms in yeast.

Schmidt O, Weyer Y, Fink MJ, Müller M, Weys S, Bindreither M, Teis D.

FEBS Lett. 2017 Sep;591(18):2803-2815. doi: 10.1002/1873-3468.12785. Epub 2017 Aug 24.

20.

High mobility group A1 protein modulates autophagy in cancer cells.

Conte A, Paladino S, Bianco G, Fasano D, Gerlini R, Tornincasa M, Renna M, Fusco A, Tramontano D, Pierantoni GM.

Cell Death Differ. 2017 Nov;24(11):1948-1962. doi: 10.1038/cdd.2017.117. Epub 2017 Aug 4.

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