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Items: 1 to 20 of 48

1.

Tween 85-Modified Low Molecular Weight PEI Enhances Exon-Skipping of Antisense Morpholino Oligomer In Vitro and in mdx Mice.

Wang M, Wu B, Tucker JD, Shah SN, Lu P, Bollinger LE, Lu Q.

Mol Ther Nucleic Acids. 2017 Dec 15;9:120-131. doi: 10.1016/j.omtn.2017.09.006. Epub 2017 Sep 20.

2.

Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides.

Zhang N, Bing T, Liu X, Qi C, Shen L, Wang L, Shangguan D.

Chem Sci. 2015 Jul 1;6(7):3831-3838. doi: 10.1039/c4sc03949a. Epub 2015 Apr 7.

3.

Pharmacokinetic Properties of DNA Aptamers with Base Modifications.

Gupta S, Drolet DW, Wolk SK, Waugh SM, Rohloff JC, Carter JD, Mayfield WS, Otis MR, Fowler CR, Suzuki T, Hirota M, Ishikawa Y, Schneider DJ, Janjic N.

Nucleic Acid Ther. 2017 Dec;27(6):345-353. doi: 10.1089/nat.2017.0683. Epub 2017 Sep 29.

4.

Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors.

Ambady P, Wu YJ, Walker JM, Kersch C, Pagel MA, Woltjer RL, Fu R, Muldoon LL, Neuwelt EA.

Cancer Gene Ther. 2017 Aug;24(8):348-357. doi: 10.1038/cgt.2017.27. Epub 2017 Jul 28.

5.

A Novel Family of Small Molecules that Enhance the Intracellular Delivery and Pharmacological Effectiveness of Antisense and Splice Switching Oligonucleotides.

Wang L, Ariyarathna Y, Ming X, Yang B, James LI, Kreda SM, Porter M, Janzen W, Juliano RL.

ACS Chem Biol. 2017 Aug 18;12(8):1999-2007. doi: 10.1021/acschembio.7b00242. Epub 2017 Jul 14.

PMID:
28703575
6.

RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus.

Liang XH, Sun H, Nichols JG, Crooke ST.

Mol Ther. 2017 Sep 6;25(9):2075-2092. doi: 10.1016/j.ymthe.2017.06.002. Epub 2017 Jun 27.

7.

Pharmacology, pharmacokinetics, and metabolism of the DNA-decoy AYX1 for the prevention of acute and chronic post-surgical pain.

Mamet J, Harris S, Klukinov M, Yeomans DC, Donahue RR, Taylor BK, Eddinger K, Yaksh T, Manning DC.

Mol Pain. 2017 Jan;13:1744806917703112. doi: 10.1177/1744806917703112.

8.

Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides.

Wang S, Sun H, Tanowitz M, Liang XH, Crooke ST.

Nucleic Acids Res. 2017 May 19;45(9):5309-5322. doi: 10.1093/nar/gkx231.

9.

Intracellular Distribution and Nuclear Activity of Antisense Oligonucleotides After Unassisted Uptake in Myoblasts and Differentiated Myotubes In Vitro.

González-Barriga A, Nillessen B, Kranzen J, van Kessel IDG, Croes HJE, Aguilera B, de Visser PC, Datson NA, Mulders SAM, van Deutekom JCT, Wieringa B, Wansink DG.

Nucleic Acid Ther. 2017 Jun;27(3):144-158. doi: 10.1089/nat.2016.0641. Epub 2017 Apr 4.

10.

Delivery is key: lessons learnt from developing splice-switching antisense therapies.

Godfrey C, Desviat LR, Smedsrød B, Piétri-Rouxel F, Denti MA, Disterer P, Lorain S, Nogales-Gadea G, Sardone V, Anwar R, El Andaloussi S, Lehto T, Khoo B, Brolin C, van Roon-Mom WM, Goyenvalle A, Aartsma-Rus A, Arechavala-Gomeza V.

EMBO Mol Med. 2017 May;9(5):545-557. doi: 10.15252/emmm.201607199. Review.

11.

High antiviral effect of TiO2·PL-DNA nanocomposites targeted to conservative regions of (-)RNA and (+)RNA of influenza A virus in cell culture.

Levina AS, Repkova MN, Bessudnova EV, Filippova EI, Mazurkova NA, Zarytova VF.

Beilstein J Nanotechnol. 2016 Aug 10;7:1166-1173. eCollection 2016.

12.

Aptamer-hybrid nanoparticle bioconjugate efficiently delivers miRNA-29b to non-small-cell lung cancer cells and inhibits growth by downregulating essential oncoproteins.

Perepelyuk M, Maher C, Lakshmikuttyamma A, Shoyele SA.

Int J Nanomedicine. 2016 Jul 28;11:3533-44. doi: 10.2147/IJN.S110488. eCollection 2016.

13.

Novel Targeted Therapy for Precursor B Cell Acute Lymphoblastic Leukemia: anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate.

Satake N, Duong C, Yoshida S, Oestergaard M, Chen C, Peralta R, Guo S, Seth PP, Li Y, Beckett L, Chung J, Nolta J, Nitin N, Tuscano JM.

Mol Med. 2016 Jul 22;22. doi: 10.2119/molmed.2015.00210. [Epub ahead of print]

14.

Annexin A2 facilitates endocytic trafficking of antisense oligonucleotides.

Wang S, Sun H, Tanowitz M, Liang XH, Crooke ST.

Nucleic Acids Res. 2016 Sep 6;44(15):7314-30. doi: 10.1093/nar/gkw595. Epub 2016 Jul 4.

15.

Functional Delivery of siRNA by Disulfide-Constrained Cyclic Amphipathic Peptides.

Welch JJ, Swanekamp RJ, King C, Dean DA, Nilsson BL.

ACS Med Chem Lett. 2016 Mar 30;7(6):584-9. doi: 10.1021/acsmedchemlett.6b00031. eCollection 2016 Jun 9.

16.

NF-κB decoy oligodeoxynucleotide mitigates wear particle-associated bone loss in the murine continuous infusion model.

Lin TH, Pajarinen J, Sato T, Loi F, Fan C, Córdova LA, Nabeshima A, Gibon E, Zhang R, Yao Z, Goodman SB.

Acta Biomater. 2016 Sep 1;41:273-81. doi: 10.1016/j.actbio.2016.05.038. Epub 2016 May 31.

17.

The delivery of therapeutic oligonucleotides.

Juliano RL.

Nucleic Acids Res. 2016 Aug 19;44(14):6518-48. doi: 10.1093/nar/gkw236. Epub 2016 Apr 15. Review.

18.

Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells.

Castanotto D, Lin M, Kowolik C, Koch T, Hansen BR, Oerum H, Stein CA.

Mol Ther. 2016 Jun;24(6):1117-1125. doi: 10.1038/mt.2016.54. Epub 2016 Mar 10.

19.

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activity.

Liang XH, Shen W, Sun H, Kinberger GA, Prakash TP, Nichols JG, Crooke ST.

Nucleic Acids Res. 2016 May 5;44(8):3892-907. doi: 10.1093/nar/gkw144. Epub 2016 Mar 3.

20.

DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing.

Nishina K, Piao W, Yoshida-Tanaka K, Sujino Y, Nishina T, Yamamoto T, Nitta K, Yoshioka K, Kuwahara H, Yasuhara H, Baba T, Ono F, Miyata K, Miyake K, Seth PP, Low A, Yoshida M, Bennett CF, Kataoka K, Mizusawa H, Obika S, Yokota T.

Nat Commun. 2015 Aug 10;6:7969. doi: 10.1038/ncomms8969.

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