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Items: 16


Proteomic profiling of human islets collected from frozen pancreata using laser capture microdissection.

Zhang L, Lanzoni G, Battarra M, Inverardi L, Zhang Q.

J Proteomics. 2017 Jan 6;150:149-159. doi: 10.1016/j.jprot.2016.09.002.


Enterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure.

Hodik M, Skog O, Lukinius A, Isaza-Correa JM, Kuipers J, Giepmans BN, Frisk G.

BMJ Open Diabetes Res Care. 2016 Aug 10;4(1):e000179. doi: 10.1136/bmjdrc-2015-000179.


Regulation of Bim in Health and Disease.

Sionov RV, Vlahopoulos SA, Granot Z.

Oncotarget. 2015 Sep 15;6(27):23058-134. Review.


Mechanisms of Beta Cell Dysfunction Associated With Viral Infection.

Petzold A, Solimena M, Knoch KP.

Curr Diab Rep. 2015 Oct;15(10):73. doi: 10.1007/s11892-015-0654-x. Review.


Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells.

Marroqui L, Lopes M, dos Santos RS, Grieco FA, Roivainen M, Richardson SJ, Morgan NG, Op de Beeck A, Eizirik DL.

Elife. 2015 Jun 10;4:e06990. doi: 10.7554/eLife.06990.


Nova1 is a master regulator of alternative splicing in pancreatic beta cells.

Villate O, Turatsinze JV, Mascali LG, Grieco FA, Nogueira TC, Cunha DA, Nardelli TR, Sammeth M, Salunkhe VA, Esguerra JL, Eliasson L, Marselli L, Marchetti P, Eizirik DL.

Nucleic Acids Res. 2014 Oct;42(18):11818-30. doi: 10.1093/nar/gku861.


Death waits for no man--does it wait for a virus? How enteroviruses induce and control cell death.

Harris KG, Coyne CB.

Cytokine Growth Factor Rev. 2014 Oct;25(5):587-96. doi: 10.1016/j.cytogfr.2014.08.002. Review.


The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity.

Wali JA, Rondas D, McKenzie MD, Zhao Y, Elkerbout L, Fynch S, Gurzov EN, Akira S, Mathieu C, Kay TW, Overbergh L, Strasser A, Thomas HE.

Cell Death Dis. 2014 Mar 13;5:e1124. doi: 10.1038/cddis.2014.88.


Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance.

Miani M, Barthson J, Colli ML, Brozzi F, Cnop M, Eizirik DL.

Cell Death Dis. 2013 Jul 4;4:e701. doi: 10.1038/cddis.2013.236.


GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.

Nogueira TC, Paula FM, Villate O, Colli ML, Moura RF, Cunha DA, Marselli L, Marchetti P, Cnop M, Julier C, Eizirik DL.

PLoS Genet. 2013 May;9(5):e1003532. doi: 10.1371/journal.pgen.1003532.


In type 1 diabetes a subset of anti-coxsackievirus B4 antibodies recognize autoantigens and induce apoptosis of pancreatic beta cells.

Bason C, Lorini R, Lunardi C, Dolcino M, Giannattasio A, d'Annunzio G, Rigo A, Pedemonte N, Corrocher R, Puccetti A.

PLoS One. 2013;8(2):e57729. doi: 10.1371/journal.pone.0057729.


PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells.

Liu X, Bennett RL, Cheng X, Byrne M, Reinhard MK, May WS Jr.

Blood. 2013 Apr 25;121(17):3364-74. doi: 10.1182/blood-2012-09-456400.


USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis.

Santin I, Moore F, Grieco FA, Marchetti P, Brancolini C, Eizirik DL.

Cell Death Dis. 2012 Nov 15;3:e419. doi: 10.1038/cddis.2012.158.


The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.

Eizirik DL, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo-Esteve M, Ortis F, Santin I, Colli ML, Barthson J, Bouwens L, Hughes L, Gregory L, Lunter G, Marselli L, Marchetti P, McCarthy MI, Cnop M.

PLoS Genet. 2012;8(3):e1002552. doi: 10.1371/journal.pgen.1002552.


The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.

Moore F, Santin I, Nogueira TC, Gurzov EN, Marselli L, Marchetti P, Eizirik DL.

PLoS One. 2012;7(2):e31062. doi: 10.1371/journal.pone.0031062.


PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.

Santin I, Moore F, Colli ML, Gurzov EN, Marselli L, Marchetti P, Eizirik DL.

Diabetes. 2011 Dec;60(12):3279-88. doi: 10.2337/db11-0758.

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