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Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells.

Elia I, Broekaert D, Christen S, Boon R, Radaelli E, Orth MF, Verfaillie C, Grünewald TGP, Fendt SM.

Nat Commun. 2017 May 11;8:15267. doi: 10.1038/ncomms15267.


Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line.

Lau CE, Tredwell GD, Ellis JK, Lam EW, Keun HC.

Sci Rep. 2017 Apr 10;7:46079. doi: 10.1038/srep46079.


Oncogenic role of PDK4 in human colon cancer cells.

Leclerc D, Pham DN, Lévesque N, Truongcao M, Foulkes WD, Sapienza C, Rozen R.

Br J Cancer. 2017 Mar 28;116(7):930-936. doi: 10.1038/bjc.2017.38. Epub 2017 Feb 16.


LKB1 promotes metabolic flexibility in response to energy stress.

Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM.

Metab Eng. 2016 Dec 26. pii: S1096-7176(16)30282-8. doi: 10.1016/j.ymben.2016.12.010. [Epub ahead of print]


Regulation of Pyruvate Dehydrogenase Kinase 4 in the Heart through Degradation by the Lon Protease in Response to Mitochondrial Substrate Availability.

Crewe C, Schafer C, Lee I, Kinter M, Szweda LI.

J Biol Chem. 2017 Jan 6;292(1):305-312. doi: 10.1074/jbc.M116.754127. Epub 2016 Nov 17.


Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells.

Morris BA, Burkel B, Ponik SM, Fan J, Condeelis JS, Aguirre-Ghiso JA, Castracane J, Denu JM, Keely PJ.

EBioMedicine. 2016 Nov;13:146-156. doi: 10.1016/j.ebiom.2016.10.012. Epub 2016 Oct 8.


Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma.

Vartanian A, Agnihotri S, Wilson MR, Burrell KE, Tonge PD, Alamsahebpour A, Jalali S, Taccone MS, Mansouri S, Golbourn B, Aldape KD, Zadeh G.

Oncotarget. 2016 Oct 25;7(43):69518-69535. doi: 10.18632/oncotarget.11680.


The ERK signaling target RNF126 regulates anoikis resistance in cancer cells by changing the mitochondrial metabolic flux.

Yoshino S, Hara T, Nakaoka HJ, Kanamori A, Murakami Y, Seiki M, Sakamoto T.

Cell Discov. 2016 Jul 26;2:16019. doi: 10.1038/celldisc.2016.19. eCollection 2016.


Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer.

Zhang Y, Zhang Y, Geng L, Yi H, Huo W, Talmon G, Kim YC, Wang SM, Wang J.

J Biol Chem. 2016 Aug 12;291(33):17405-16. doi: 10.1074/jbc.M116.713735. Epub 2016 Jun 21.


Coping with the metabolic stress of leaving home.

Coloff JL, Brugge JS.

Cell Res. 2016 Jul;26(7):757-8. doi: 10.1038/cr.2016.61. Epub 2016 May 24.


Reductive carboxylation supports redox homeostasis during anchorage-independent growth.

Jiang L, Shestov AA, Swain P, Yang C, Parker SJ, Wang QA, Terada LS, Adams ND, McCabe MT, Pietrak B, Schmidt S, Metallo CM, Dranka BP, Schwartz B, DeBerardinis RJ.

Nature. 2016 Apr 14;532(7598):255-8. doi: 10.1038/nature17393. Epub 2016 Apr 6.


Transcriptome adaptation of the bovine mammary gland to diets rich in unsaturated fatty acids shows greater impact of linseed oil over safflower oil on gene expression and metabolic pathways.

Ibeagha-Awemu EM, Li R, Ammah AA, Dudemaine PL, Bissonnette N, Benchaar C, Zhao X.

BMC Genomics. 2016 Feb 9;17:104. doi: 10.1186/s12864-016-2423-x.


Metformin suppressed the proliferation of LoVo cells and induced a time-dependent metabolic and transcriptional alteration.

He J, Wang K, Zheng N, Qiu Y, Xie G, Su M, Jia W, Li H.

Sci Rep. 2015 Nov 30;5:17423. doi: 10.1038/srep17423.


Enzymatic passaging of human embryonic stem cells alters central carbon metabolism and glycan abundance.

Badur MG, Zhang H, Metallo CM.

Biotechnol J. 2015 Oct;10(10):1600-11. doi: 10.1002/biot.201400749. Epub 2015 Sep 10.


3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.

Konstantakou EG, Voutsinas GE, Velentzas AD, Basogianni AS, Paronis E, Balafas E, Kostomitsopoulos N, Syrigos KN, Anastasiadou E, Stravopodis DJ.

Mol Cancer. 2015 Jul 22;14:135. doi: 10.1186/s12943-015-0399-9.


Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells.

Rajagopalan KN, Egnatchik RA, Calvaruso MA, Wasti AT, Padanad MS, Boroughs LK, Ko B, Hensley CT, Acar M, Hu Z, Jiang L, Pascual JM, Scaglioni PP, DeBerardinis RJ.

Cancer Metab. 2015 Jun 29;3:7. doi: 10.1186/s40170-015-0134-4. eCollection 2015.


LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells.

Whang YM, Park SI, Trenary IA, Egnatchik RA, Fessel JP, Kaufman JM, Carbone DP, Young JD.

Oncogene. 2016 Feb 18;35(7):856-66. doi: 10.1038/onc.2015.140. Epub 2015 Jun 29.


Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment.

Schumann T, Adhikary T, Wortmann A, Finkernagel F, Lieber S, Schnitzer E, Legrand N, Schober Y, Nockher WA, Toth PM, Diederich WE, Nist A, Stiewe T, Wagner U, Reinartz S, Müller-Brüsselbach S, Müller R.

Oncotarget. 2015 May 30;6(15):13416-33.


Mitochondria as biosynthetic factories for cancer proliferation.

Ahn CS, Metallo CM.

Cancer Metab. 2015 Jan 25;3(1):1. doi: 10.1186/s40170-015-0128-2. eCollection 2015.


Acetate is a bioenergetic substrate for human glioblastoma and brain metastases.

Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C, Huang Z, Barnett S, Mickey BE, DeBerardinis RJ, Tu BP, Maher EA, Bachoo RM.

Cell. 2014 Dec 18;159(7):1603-14. doi: 10.1016/j.cell.2014.11.025.

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