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Items: 1 to 20 of 369


Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels.

Sula A, Wallace BA.

J Gen Physiol. 2017 Jun 5;149(6):613-622. doi: 10.1085/jgp.201611740. Epub 2017 May 18. Review.


Molecular dynamics simulations of membrane proteins.

Baştuğ T, Kuyucak S.

Biophys Rev. 2012 Sep;4(3):271-282. doi: 10.1007/s12551-012-0084-9. Epub 2012 Sep 1. Review.


A selectivity filter at the intracellular end of the acid-sensing ion channel pore.

Lynagh T, Flood E, Boiteux C, Wulf M, Komnatnyy VV, Colding JM, Allen TW, Pless SA.

Elife. 2017 May 12;6. pii: e24630. doi: 10.7554/eLife.24630.


Isoflurane modulates activation and inactivation gating of the prokaryotic Na+ channel NaChBac.

Sand RM, Gingrich KJ, Macharadze T, Herold KF, Hemmings HC Jr.

J Gen Physiol. 2017 Jun 5;149(6):623-638. doi: 10.1085/jgp.201611600. Epub 2017 Apr 17.


The chemical basis for electrical signaling.

Catterall WA, Wisedchaisri G, Zheng N.

Nat Chem Biol. 2017 Apr 13;13(5):455-463. doi: 10.1038/nchembio.2353. Review.


Small molecule modulation of voltage gated sodium channels.

Carnevale V, Klein ML.

Curr Opin Struct Biol. 2017 Apr;43:156-162. doi: 10.1016/ Epub 2017 Mar 28. Review.


A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore.

Tomczak AP, Fernández-Trillo J, Bharill S, Papp F, Panyi G, Stühmer W, Isacoff EY, Pardo LA.

J Gen Physiol. 2017 May 1;149(5):577-593. doi: 10.1085/jgp.201611742. Epub 2017 Mar 30.


Structures of closed and open states of a voltage-gated sodium channel.

Lenaeus MJ, Gamal El-Din TM, Ing C, Ramanadane K, Pomès R, Zheng N, Catterall WA.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3051-E3060. doi: 10.1073/pnas.1700761114. Epub 2017 Mar 27.


Sodium channel biophysics, late sodium current and genetic arrhythmic syndromes.

Chadda KR, Jeevaratnam K, Lei M, Huang CL.

Pflugers Arch. 2017 Jun;469(5-6):629-641. doi: 10.1007/s00424-017-1959-1. Epub 2017 Mar 6. Review.


Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants.

Tikhonov DB, Zhorov BS.

J Gen Physiol. 2017 Apr 3;149(4):465-481. doi: 10.1085/jgp.201611668. Epub 2017 Mar 3.


Network topology of NaV1.7 mutations in sodium channel-related painful disorders.

Kapetis D, Sassone J, Yang Y, Galbardi B, Xenakis MN, Westra RL, Szklarczyk R, Lindsey P, Faber CG, Gerrits M, Merkies IS, Dib-Hajj SD, Mantegazza M, Waxman SG, Lauria G; PROPANE Study Group.

BMC Syst Biol. 2017 Feb 24;11(1):28. doi: 10.1186/s12918-016-0382-0.


The complete structure of an activated open sodium channel.

Sula A, Booker J, Ng LC, Naylor CE, DeCaen PG, Wallace BA.

Nat Commun. 2017 Feb 16;8:14205. doi: 10.1038/ncomms14205.


Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.

Kubota T, Durek T, Dang B, Finol-Urdaneta RK, Craik DJ, Kent SB, French RJ, Bezanilla F, Correa AM.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1857-E1865. doi: 10.1073/pnas.1700453114. Epub 2017 Feb 15.


Structure-based assessment of disease-related mutations in human voltage-gated sodium channels.

Huang W, Liu M, Yan SF, Yan N.

Protein Cell. 2017 Jun;8(6):401-438. doi: 10.1007/s13238-017-0372-z. Epub 2017 Feb 1. Review.


Lacosamide Inhibition of Nav1.7 Voltage-Gated Sodium Channels: Slow Binding to Fast-Inactivated States.

Jo S, Bean BP.

Mol Pharmacol. 2017 Apr;91(4):277-286. doi: 10.1124/mol.116.106401. Epub 2017 Jan 24.


Antinociceptive Effects of AGAP, a Recombinant Neurotoxic Polypeptide: Possible Involvement of the Tetrodotoxin-Resistant Sodium Channels in Small Dorsal Root Ganglia Neurons.

Li CL, Liu XF, Li GX, Ban MQ, Chen JZ, Cui Y, Zhang JH, Wu CF.

Front Pharmacol. 2016 Dec 20;7:496. doi: 10.3389/fphar.2016.00496. eCollection 2016.


A Novel Toxin from Haplopelma lividum Selectively Inhibits the NaV1.8 Channel and Possesses Potent Analgesic Efficacy.

Meng P, Huang H, Wang G, Yang S, Lu Q, Liu J, Lai R, Rong M.

Toxins (Basel). 2016 Dec 26;9(1). pii: E7. doi: 10.3390/toxins9010007.


Isolated pores dissected from human two-pore channel 2 are functional.

Penny CJ, Rahman T, Sula A, Miles AJ, Wallace BA, Patel S.

Sci Rep. 2016 Dec 12;6:38426. doi: 10.1038/srep38426.


Crystal structures of the TRIC trimeric intracellular cation channel orthologues.

Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, Hattori M, Nureki O.

Cell Res. 2016 Dec;26(12):1288-1301. doi: 10.1038/cr.2016.140.


Voltage-Gated Na+ Channel Isoforms and Their mRNA Expression Levels and Protein Abundance in Three Electric Organs and the Skeletal Muscle of the Electric Eel Electrophorus electricus.

Ching B, Woo JM, Hiong KC, Boo MV, Wong WP, Chew SF, Ip YK.

PLoS One. 2016 Dec 1;11(12):e0167589. doi: 10.1371/journal.pone.0167589. eCollection 2016.

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