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Items: 1 to 20 of 41

1.

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel.

Nemecz Á, Hu H, Fourati Z, Van Renterghem C, Delarue M, Corringer PJ.

PLoS Biol. 2017 Dec 27;15(12):e2004470. doi: 10.1371/journal.pbio.2004470. eCollection 2017 Dec.

2.

A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation.

Ghosh B, Tsao TW, Czajkowski C.

Neuropharmacology. 2017 Oct;125:343-352. doi: 10.1016/j.neuropharm.2017.08.007. Epub 2017 Aug 10.

PMID:
28803966
3.

String method solution of the gating pathways for a pentameric ligand-gated ion channel.

Lev B, Murail S, Poitevin F, Cromer BA, Baaden M, Delarue M, Allen TW.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4158-E4167. doi: 10.1073/pnas.1617567114. Epub 2017 May 9.

4.

Identification of a pre-active conformation of a pentameric channel receptor.

Menny A, Lefebvre SN, Schmidpeter PA, Drège E, Fourati Z, Delarue M, Edelstein SJ, Nimigean CM, Joseph D, Corringer PJ.

Elife. 2017 Mar 15;6. pii: e23955. doi: 10.7554/eLife.23955.

5.

Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors.

Burgos CF, Yévenes GE, Aguayo LG.

Mol Pharmacol. 2016 Sep;90(3):318-25. doi: 10.1124/mol.116.105726. Epub 2016 Jul 11. Review.

6.

Potentiators exert distinct effects on human, murine, and Xenopus CFTR.

Cui G, Khazanov N, Stauffer BB, Infield DT, Imhoff BR, Senderowitz H, McCarty NA.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L192-207. doi: 10.1152/ajplung.00056.2016. Epub 2016 Jun 10.

7.

Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.

Heusser SA, Yoluk Ö, Klement G, Riederer EA, Lindahl E, Howard RJ.

J Neurochem. 2016 Jul;138(2):243-53. doi: 10.1111/jnc.13644. Epub 2016 May 25.

8.

Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors.

Jaiteh M, Taly A, Hénin J.

PLoS One. 2016 Mar 17;11(3):e0151934. doi: 10.1371/journal.pone.0151934. eCollection 2016.

9.

A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation.

Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee VC, Lodowski DT, Chakrapani S.

J Gen Physiol. 2015 Oct;146(4):323-40. doi: 10.1085/jgp.201511478.

10.

The M4 Transmembrane α-Helix Contributes Differently to Both the Maturation and Function of Two Prokaryotic Pentameric Ligand-gated Ion Channels.

Hénault CM, Juranka PF, Baenziger JE.

J Biol Chem. 2015 Oct 9;290(41):25118-28. doi: 10.1074/jbc.M115.676833. Epub 2015 Aug 28.

11.

Role of the Fourth Transmembrane α Helix in the Allosteric Modulation of Pentameric Ligand-Gated Ion Channels.

Carswell CL, Hénault CM, Murlidaran S, Therien JPD, Juranka PF, Surujballi JA, Brannigan G, Baenziger JE.

Structure. 2015 Sep 1;23(9):1655-1664. doi: 10.1016/j.str.2015.06.020. Epub 2015 Jul 30.

12.

Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses.

Burgos CF, Muñoz B, Guzman L, Aguayo LG.

Pharmacol Res. 2015 Nov;101:18-29. doi: 10.1016/j.phrs.2015.07.002. Epub 2015 Jul 6. Review.

13.

Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.

Horani S, Stater EP, Corringer PJ, Trudell JR, Harris RA, Howard RJ.

Alcohol Clin Exp Res. 2015 Jun;39(6):962-8. doi: 10.1111/acer.12735. Epub 2015 May 14.

14.

Pentameric Ligand-gated Ion Channels : Insights from Computation.

Salari R, Murlidaran S, Brannigan G.

Mol Simul. 2014 Apr 17;40(10-11):821-829.

15.

Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors.

Mnatsakanyan N, Nishtala SN, Pandhare A, Fiori MC, Goyal R, Pauwels JE, Navetta AF, Ahrorov A, Jansen M.

Biochemistry. 2015 Apr 28;54(16):2670-2682. doi: 10.1021/acs.biochem.5b00203. Epub 2015 Apr 17.

16.

The molecular pharmacology of volatile anesthetics.

Borghese CM.

Int Anesthesiol Clin. 2015 Spring;53(2):28-39. doi: 10.1097/AIA.0000000000000060. Review. No abstract available.

17.

Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.

Moraga-Cid G, Sauguet L, Huon C, Malherbe L, Girard-Blanc C, Petres S, Murail S, Taly A, Baaden M, Delarue M, Corringer PJ.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2865-70. doi: 10.1073/pnas.1417864112. Epub 2015 Feb 17.

18.

Structural requirements in the transmembrane domain of GLIC revealed by incorporation of noncanonical histidine analogs.

Rienzo M, Lummis SC, Dougherty DA.

Chem Biol. 2014 Dec 18;21(12):1700-6. doi: 10.1016/j.chembiol.2014.10.019.

19.

An internally modulated, thermostable, pH-sensitive Cys loop receptor from the hydrothermal vent worm Alvinella pompejana.

Juneja P, Horlacher R, Bertrand D, Krause R, Marger F, Welte W.

J Biol Chem. 2014 May 23;289(21):15130-40. doi: 10.1074/jbc.M113.525576. Epub 2014 Apr 9.

20.

ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation.

Tillman TS, Seyoum E, Mowrey DD, Xu Y, Tang P.

J Biol Chem. 2014 May 16;289(20):13851-7. doi: 10.1074/jbc.M113.524611. Epub 2014 Apr 2.

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