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Items: 1 to 20 of 34


Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells.

Mönke G, Cristiano E, Finzel A, Friedrich D, Herzel H, Falcke M, Loewer A.

Sci Rep. 2017 Apr 18;7:46571. doi: 10.1038/srep46571.


A piRNA-like Small RNA Induces Chemoresistance to Cisplatin-Based Therapy by Inhibiting Apoptosis in Lung Squamous Cell Carcinoma.

Wang Y, Gable T, Ma MZ, Clark D, Zhao J, Zhang Y, Liu W, Mao L, Mei Y.

Mol Ther Nucleic Acids. 2017 Mar 17;6:269-278. doi: 10.1016/j.omtn.2017.01.003. Epub 2017 Jan 24.


The PIDDosome activates p53 in response to supernumerary centrosomes.

Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A.

Genes Dev. 2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116.


BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.

López-García C, Sansregret L, Domingo E, McGranahan N, Hobor S, Birkbak NJ, Horswell S, Grönroos E, Favero F, Rowan AJ, Matthews N, Begum S, Phillimore B, Burrell R, Oukrif D, Spencer-Dene B, Kovac M, Stamp G, Stewart A, Danielsen H, Novelli M, Tomlinson I, Swanton C.

Cancer Cell. 2017 Jan 9;31(1):79-93. doi: 10.1016/j.ccell.2016.11.001.


Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate.

Kitevska T, Roberts SJ, Pantaki-Eimany D, Boyd SE, Scott FL, Hawkins CJ.

Biosci Rep. 2014 Apr 1;34(2). pii: e00100. Print 2014 Apr 1.


Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.

Machado MV, Michelotti GA, Jewell ML, Pereira TA, Xie G, Premont RT, Diehl AM.

Cell Death Dis. 2016 Feb 18;7:e2096. doi: 10.1038/cddis.2016.19.


Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?

Doktorova TY, Yildirimman R, Ceelen L, Vilardell M, Vanhaecke T, Vinken M, Ates G, Heymans A, Gmuender H, Bort R, Corvi R, Phrakonkham P, Li R, Mouchet N, Chesne C, van Delft J, Kleinjans J, Castell J, Herwig R, Rogiers V.

EXCLI J. 2014 May 28;13:623-37. eCollection 2014.


The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.

Peintner L, Dorstyn L, Kumar S, Aneichyk T, Villunger A, Manzl C.

Cell Death Differ. 2015 Nov;22(11):1803-11. doi: 10.1038/cdd.2015.31. Epub 2015 Apr 10.


Cisplatin fails to induce puma mediated apoptosis in mucosal melanomas.

Fritsche MK, Metzler V, Becker K, Plettenberg C, Heiser C, Hofauer B, Knopf A.

Oncotarget. 2015;6(12):9887-96.


Differential expression of microRNA501-5p affects the aggressiveness of clear cell renal carcinoma.

Mangolini A, Bonon A, Volinia S, Lanza G, Gambari R, Pinton P, Russo GR, Del Senno L, Dell'Atti L, Aguiari G.

FEBS Open Bio. 2014 Nov 4;4:952-65. doi: 10.1016/j.fob.2014.10.016. eCollection 2014.


Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.

Terry MR, Arya R, Mukhopadhyay A, Berrett KC, Clair PM, Witt B, Salama ME, Bhutkar A, Oliver TG.

Cell Death Differ. 2015 May;22(5):719-30. doi: 10.1038/cdd.2014.159. Epub 2014 Oct 10.


A nonapoptotic role for CASP2/caspase 2: modulation of autophagy.

Tiwari M, Sharma LK, Vanegas D, Callaway DA, Bai Y, Lechleiter JD, Herman B.

Autophagy. 2014 Jun;10(6):1054-70. doi: 10.4161/auto.28528.


Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death.

Vakifahmetoglu-Norberg H, Norberg E, Perdomo AB, Olsson M, Ciccosanti F, Orrenius S, Fimia GM, Piacentini M, Zhivotovsky B.

Cell Death Dis. 2013 Dec 5;4:e940. doi: 10.1038/cddis.2013.463.


Arrestins in apoptosis.

Kook S, Gurevich VV, Gurevich EV.

Handb Exp Pharmacol. 2014;219:309-39. doi: 10.1007/978-3-642-41199-1_16.


The MDM2-p53 pathway revisited.

Nag S, Qin J, Srivenugopal KS, Wang M, Zhang R.

J Biomed Res. 2013 Jul;27(4):254-71. doi: 10.7555/JBR.27.20130030. Epub 2013 Jun 6.


hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression.

Avasarala S, Van Scoyk M, Wang J, Sechler M, Vandervest K, Brzezinski C, Weekes C, Edwards MG, Arcaroli J, Davis RE, Bikkavilli RK, Winn RA.

Biol Open. 2013 May 22;2(7):675-85. doi: 10.1242/bio.20134507. Print 2013 Jul 15.


Caspase-2 as a tumour suppressor.

Puccini J, Dorstyn L, Kumar S.

Cell Death Differ. 2013 Sep;20(9):1133-9. doi: 10.1038/cdd.2013.87. Epub 2013 Jun 28. Review.


Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.

Parsons MJ, McCormick L, Janke L, Howard A, Bouchier-Hayes L, Green DR.

Cell Death Differ. 2013 Sep;20(9):1174-82. doi: 10.1038/cdd.2013.38. Epub 2013 May 3.


The tangled circuitry of metabolism and apoptosis.

Andersen JL, Kornbluth S.

Mol Cell. 2013 Feb 7;49(3):399-410. doi: 10.1016/j.molcel.2012.12.026. Review.


Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis.

Locke WJ, Clark SJ.

Breast Cancer Res. 2012 Nov 15;14(6):215. doi: 10.1186/bcr3237. Review.

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