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Items: 1 to 20 of 27


Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.

DiStefano PV, Smrcka AV, Glading AJ.

PLoS One. 2016 Sep 9;11(9):e0162338. doi: 10.1371/journal.pone.0162338. eCollection 2016.


Phospholipase C-ε signaling mediates endothelial cell inflammation and barrier disruption in acute lung injury.

Bijli KM, Fazal F, Slavin SA, Leonard A, Grose V, Alexander WB, Smrcka AV, Rahman A.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L517-24. doi: 10.1152/ajplung.00069.2016. Epub 2016 Jul 1.


Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins.

Calejo AI, Taskén K.

Front Pharmacol. 2015 Sep 8;6:192. doi: 10.3389/fphar.2015.00192. eCollection 2015. Review.


Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase Cϵ.

Dusaban SS, Kunkel MT, Smrcka AV, Brown JH.

J Biol Chem. 2015 Oct 30;290(44):26776-83. doi: 10.1074/jbc.M115.676098. Epub 2015 Sep 8.


The role of mAKAPβ in the process of cardiomyocyte hypertrophy induced by angiotensin II.

Guo H, Liu B, Hou L, The E, Li G, Wang D, Jie Q, Che W, Wei Y.

Int J Mol Med. 2015 May;35(5):1159-68. doi: 10.3892/ijmm.2015.2119. Epub 2015 Mar 2.


Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes.

Smrcka AV.

J Cardiovasc Pharmacol. 2015 Mar;65(3):203-10. doi: 10.1097/FJC.0000000000000195. Review.


G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.

Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV.

Mol Biol Cell. 2015 Mar 15;26(6):1188-98. doi: 10.1091/mbc.E14-10-1476. Epub 2015 Jan 21.


mAKAP-a master scaffold for cardiac remodeling.

Passariello CL, Li J, Dodge-Kafka K, Kapiloff MS.

J Cardiovasc Pharmacol. 2015 Mar;65(3):218-25. doi: 10.1097/FJC.0000000000000206. Review.


PLCε mediated sustained signaling pathways.

Dusaban SS, Brown JH.

Adv Biol Regul. 2015 Jan;57:17-23. doi: 10.1016/j.jbior.2014.09.014. Epub 2014 Oct 5. Review.


Nuclear compartmentalization of α1-adrenergic receptor signaling in adult cardiac myocytes.

Wu SC, OʼConnell TD.

J Cardiovasc Pharmacol. 2015 Feb;65(2):91-100. doi: 10.1097/FJC.0000000000000165. Review.


Anchored protein kinase A signalling in cardiac cellular electrophysiology.

Soni S, Scholten A, Vos MA, van Veen TA.

J Cell Mol Med. 2014 Nov;18(11):2135-46. doi: 10.1111/jcmm.12365. Epub 2014 Sep 12. Review.


Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke.

Oldenburger A, Timens W, Bos S, Smit M, Smrcka AV, Laurent AC, Cao J, Hylkema M, Meurs H, Maarsingh H, Lezoualc'h F, Schmidt M.

FASEB J. 2014 Nov;28(11):4617-28. doi: 10.1096/fj.13-248930. Epub 2014 Aug 7.


An integrated mechanism of cardiomyocyte nuclear Ca(2+) signaling.

Ibarra C, Vicencio JM, Varas-Godoy M, Jaimovich E, Rothermel BA, Uhlén P, Hill JA, Lavandero S.

J Mol Cell Cardiol. 2014 Oct;75:40-8. doi: 10.1016/j.yjmcc.2014.06.015. Epub 2014 Jul 2. Review.


The scaffold protein muscle A-kinase anchoring protein β orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure.

Kritzer MD, Li J, Passariello CL, Gayanilo M, Thakur H, Dayan J, Dodge-Kafka K, Kapiloff MS.

Circ Heart Fail. 2014 Jul;7(4):663-72. doi: 10.1161/CIRCHEARTFAILURE.114.001266. Epub 2014 May 8.


Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance.

O'Connell TD, Jensen BC, Baker AJ, Simpson PC.

Pharmacol Rev. 2013 Dec 24;66(1):308-33. doi: 10.1124/pr.112.007203. Print 2014. Review.


AKAP signaling complexes: pointing towards the next generation of therapeutic targets?

Esseltine JL, Scott JD.

Trends Pharmacol Sci. 2013 Dec;34(12):648-55. doi: 10.1016/ Epub 2013 Nov 12. Review.


Phosphoinositides: tiny lipids with giant impact on cell regulation.

Balla T.

Physiol Rev. 2013 Jul;93(3):1019-137. doi: 10.1152/physrev.00028.2012. Review.


A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy.

Pérez López I, Cariolato L, Maric D, Gillet L, Abriel H, Diviani D.

Mol Cell Biol. 2013 Aug;33(15):2903-17. doi: 10.1128/MCB.00031-13. Epub 2013 May 28. Erratum in: Mol Cell Biol. 2013 Sep;33(18):3724.


Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV.

Cell. 2013 Mar 28;153(1):216-27. doi: 10.1016/j.cell.2013.02.047.


Small molecule inhibitors of phospholipase C from a novel high-throughput screen.

Huang W, Barrett M, Hajicek N, Hicks S, Harden TK, Sondek J, Zhang Q.

J Biol Chem. 2013 Feb 22;288(8):5840-8. doi: 10.1074/jbc.M112.422501. Epub 2013 Jan 7.

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