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Items: 1 to 20 of 23

1.

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease.

Kumari N, Ammosova T, Diaz S, Lin X, Niu X, Ivanov A, Jerebtsova M, Dhawan S, Oneal P, Nekhai S.

Blood Adv. 2016 Dec 27;1(3):170-183. doi: 10.1182/bloodadvances.2016000745.

2.

Positive feedback loop mediated by protein phosphatase 1α mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer.

Liu X, Gao Y, Ye H, Gerrin S, Ma F, Wu Y, Zhang T, Russo J, Cai C, Yuan X, Liu J, Chen S, Balk SP.

Nucleic Acids Res. 2017 Apr 20;45(7):3738-3751. doi: 10.1093/nar/gkw1291.

3.

The mTOR Complex Controls HIV Latency.

Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E.

Cell Host Microbe. 2016 Dec 14;20(6):785-797. doi: 10.1016/j.chom.2016.11.001.

PMID:
27978436
4.

Protein Phosphatase-1 Regulates Expression of Neuregulin-1.

Ammosova T, Washington K, Rotimi J, Kumari N, Smith KA, Niu X, Jerebtsova M, Nekhai S.

Biology (Basel). 2016 Dec 2;5(4). pii: E49.

5.

An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb.

Kobbi L, Demey-Thomas E, Braye F, Proux F, Kolesnikova O, Vinh J, Poterszman A, Bensaude O.

Proc Natl Acad Sci U S A. 2016 Oct 25. pii: 201612331. [Epub ahead of print]

6.

Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb.

C Quaresma AJ, Bugai A, Barboric M.

Nucleic Acids Res. 2016 Sep 19;44(16):7527-39. doi: 10.1093/nar/gkw585. Epub 2016 Jul 1. Review.

7.

Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1.

Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S.

Retrovirology. 2015 Jul 16;12:63. doi: 10.1186/s12977-015-0190-4.

8.

The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis.

Bottardi S, Mavoungou L, Pak H, Daou S, Bourgoin V, Lakehal YA, Affar el B, Milot E.

PLoS Genet. 2014 Dec 4;10(12):e1004827. doi: 10.1371/journal.pgen.1004827. eCollection 2014 Dec.

9.

1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.

Ammosova T, Platonov M, Ivanov A, Kont YS, Kumari N, Kehn-Hall K, Jerebtsova M, Kulkarni AA, Uren A, Kovalskyy D, Nekhai S.

Br J Pharmacol. 2014 Nov;171(22):5059-75. doi: 10.1111/bph.12863.

10.

Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription.

Ilinykh PA, Tigabu B, Ivanov A, Ammosova T, Obukhov Y, Garron T, Kumari N, Kovalskyy D, Platonov MO, Naumchik VS, Freiberg AN, Nekhai S, Bukreyev A.

J Biol Chem. 2014 Aug 15;289(33):22723-38. doi: 10.1074/jbc.M114.575050. Epub 2014 Jun 16.

11.

Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4+ T Lymphocytes and Macrophages.

Ramakrishnan R, Chiang K, Liu H, Budhiraja S, Donahue H, Rice AP.

Biology (Basel). 2012 Jun 15;1(1):94-115. doi: 10.3390/biology1010094.

12.

Regulation of CDK9 activity by phosphorylation and dephosphorylation.

Nekhai S, Petukhov M, Breuer D.

Biomed Res Int. 2014;2014:964964. doi: 10.1155/2014/964964. Epub 2014 Jan 12. Review.

13.

Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival.

Chang MJ, Zhong F, Lavik AR, Parys JB, Berridge MJ, Distelhorst CW.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1186-91. doi: 10.1073/pnas.1323098111. Epub 2014 Jan 6.

14.

Lipid rafts contribute to agonist-induced serine/threonine phosphatase activation and platelet aggregation.

Pradhan S, Vijayan KV.

J Thromb Haemost. 2013 Aug;11(8):1612-5. doi: 10.1111/jth.12329. No abstract available.

15.

High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1.

Zhou X, Wang H, Burg MB, Ferraris JD.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F362-9. doi: 10.1152/ajprenal.00218.2013. Epub 2013 May 29.

16.

Role of cellular iron and oxygen in the regulation of HIV-1 infection.

Nekhai S, Kumari N, Dhawan S.

Future Virol. 2013 Mar;8(3):301-311.

17.

Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.

Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, Karn J.

PLoS Pathog. 2013;9(5):e1003338. doi: 10.1371/journal.ppat.1003338. Epub 2013 May 2.

18.

Lost in transcription: molecular mechanisms that control HIV latency.

Taube R, Peterlin M.

Viruses. 2013 Mar 21;5(3):902-27. doi: 10.3390/v5030902. Review.

19.

CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90.

Breuer D, Kotelkin A, Ammosova T, Kumari N, Ivanov A, Ilatovskiy AV, Beullens M, Roane PR, Bollen M, Petukhov MG, Kashanchi F, Nekhai S.

Retrovirology. 2012 Nov 9;9:94. doi: 10.1186/1742-4690-9-94.

20.

Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.

Ammosova T, Platonov M, Yedavalli VR, Obukhov Y, Gordeuk VR, Jeang KT, Kovalskyy D, Nekhai S.

PLoS One. 2012;7(6):e39481. doi: 10.1371/journal.pone.0039481. Epub 2012 Jun 29.

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