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Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

Chakravarthy H, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, Herrera PL, Kim SK.

Cell Metab. 2017 Mar 7;25(3):622-634. doi: 10.1016/j.cmet.2017.01.009.


β Cells led astray by transcription factors and the company they keep.

Thompson P, Bhushan A.

J Clin Invest. 2017 Jan 3;127(1):94-97. doi: 10.1172/JCI91304.


Epigenetic control of β-cell function and failure.

Bernstein D, Golson ML, Kaestner KH.

Diabetes Res Clin Pract. 2017 Jan;123:24-36. doi: 10.1016/j.diabres.2016.11.009. Review.


Stress-induced adaptive islet cell identity changes.

Cigliola V, Thorel F, Chera S, Herrera PL.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:87-96. doi: 10.1111/dom.12726. Review.


β-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas.

Kim HS, Lee MK.

J Diabetes Investig. 2016 May;7(3):286-96. doi: 10.1111/jdi.12475. Review.


Generation of Functional Beta-Like Cells from Human Exocrine Pancreas.

Lima MJ, Muir KR, Docherty HM, McGowan NW, Forbes S, Heremans Y, Heimberg H, Casey J, Docherty K.

PLoS One. 2016 May 31;11(5):e0156204. doi: 10.1371/journal.pone.0156204.


Insulin-secreting β cells require a post-genomic concept.

Jiang FX, Morahan G.

World J Diabetes. 2016 May 25;7(10):198-208. doi: 10.4239/wjd.v7.i10.198. Review.


Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes.

Ackermann AM, Wang Z, Schug J, Naji A, Kaestner KH.

Mol Metab. 2016 Jan 11;5(3):233-44. doi: 10.1016/j.molmet.2016.01.002.


Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming.

Zhou Y, Wang L, Vaseghi HR, Liu Z, Lu R, Alimohamadi S, Yin C, Fu JD, Wang GG, Liu J, Qian L.

Cell Stem Cell. 2016 Mar 3;18(3):382-95. doi: 10.1016/j.stem.2016.02.003.


Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication.

Dhawan S, Dirice E, Kulkarni RN, Bhushan A.

Diabetes. 2016 May;65(5):1208-18. doi: 10.2337/db15-1331.


β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.

Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S.

PLoS One. 2016 Feb 22;11(2):e0150010. doi: 10.1371/journal.pone.0150010.


ActivinB Is Induced in Insulinoma To Promote Tumor Plasticity through a β-Cell-Induced Dedifferentiation.

Ripoche D, Charbord J, Hennino A, Teinturier R, Bonnavion R, Jaafar R, Goehrig D, Cordier-Bussat M, Ritvos O, Zhang CX, Andersson O, Bertolino P.

Mol Cell Biol. 2015 Dec 28;36(5):756-64. doi: 10.1128/MCB.00930-15.


Evolving function and potential of pancreatic alpha cells.

Stanojevic V, Habener JF.

Best Pract Res Clin Endocrinol Metab. 2015 Dec;29(6):859-71. doi: 10.1016/j.beem.2015.10.002. Review.


The double trouble of metabolic diseases: the diabetes-cancer link.

Tudzarova S, Osman MA.

Mol Biol Cell. 2015 Sep 15;26(18):3129-39. doi: 10.1091/mbc.E14-11-1550.


DNA methylation directs functional maturation of pancreatic β cells.

Dhawan S, Tschen SI, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A.

J Clin Invest. 2015 Jul 1;125(7):2851-60. doi: 10.1172/JCI79956.


Epigenetic programming of glucose-regulated insulin release.

Schuit F.

J Clin Invest. 2015 Jul 1;125(7):2565-8. doi: 10.1172/JCI82575.


Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.

Blodgett DM, Nowosielska A, Afik S, Pechhold S, Cura AJ, Kennedy NJ, Kim S, Kucukural A, Davis RJ, Kent SC, Greiner DL, Garber MG, Harlan DM, diIorio P.

Diabetes. 2015 Sep;64(9):3172-81. doi: 10.2337/db15-0039.


Epigenetic modifications and long noncoding RNAs influence pancreas development and function.

Arnes L, Sussel L.

Trends Genet. 2015 Jun;31(6):290-9. doi: 10.1016/j.tig.2015.02.008. Review.


Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells.

McKenna B, Guo M, Reynolds A, Hara M, Stein R.

Cell Rep. 2015 Mar 31;10(12):2032-42. doi: 10.1016/j.celrep.2015.02.054.


Role of transcription factors in the transdifferentiation of pancreatic islet cells.

van der Meulen T, Huising MO.

J Mol Endocrinol. 2015 Apr;54(2):R103-17. doi: 10.1530/JME-14-0290. Review.

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