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Items: 1 to 20 of 71


Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines.

Sen M, Johnston PA, Pollock NI, DeGrave K, Joyce SC, Freilino ML, Hua Y, Camarco DP, Close DA, Huryn DM, Wipf P, Grandis JR.

J Chem Biol. 2017 May 11;10(3):129-141. doi: 10.1007/s12154-017-0169-9. eCollection 2017 Jul.


Metal complexes as potential modulators of inflammatory and autoimmune responses.

Leung CH, Lin S, Zhong HJ, Ma DL.

Chem Sci. 2015 Feb 2;6(2):871-884. doi: 10.1039/c4sc03094j. Epub 2014 Nov 7.


Inhibiting STAT3 signaling is involved in the anti-melanoma effects of a herbal formula comprising Sophorae Flos and Lonicerae Japonicae Flos.

Li T, Fu X, Tse AK, Guo H, Lee KW, Liu B, Su T, Wang X, Yu Z.

Sci Rep. 2017 Jun 8;7(1):3097. doi: 10.1038/s41598-017-03351-2.


Silencing of type Iγ phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion.

Cao S, Chen C, Xue J, Huang Y, Yang X, Ling K.

Oncol Rep. 2017 Jul;38(1):253-262. doi: 10.3892/or.2017.5670. Epub 2017 May 25.


An Ethanolic Extract of Ampelopsis Radix Exerts Anti-colorectal Cancer Effects and Potently Inhibits STAT3 Signaling In Vitro.

Su T, Bai JX, Chen YJ, Wang XN, Fu XQ, Li T, Guo H, Zhu PL, Wang Y, Yu ZL.

Front Pharmacol. 2017 Apr 28;8:227. doi: 10.3389/fphar.2017.00227. eCollection 2017.


Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo.

Komar HM, Serpa G, Kerscher C, Schwoegl E, Mace TA, Jin M, Yang MC, Chen CS, Bloomston M, Ostrowski MC, Hart PA, Conwell DL, Lesinski GB.

Sci Rep. 2017 May 11;7(1):1787. doi: 10.1038/s41598-017-01973-0.


Endogenously Expressed IL-4Rα Promotes the Malignant Phenotype of Human Pancreatic Cancer In Vitro and In Vivo.

Traub B, Sun L, Ma Y, Xu P, Lemke J, Paschke S, Henne-Bruns D, Knippschild U, Kornmann M.

Int J Mol Sci. 2017 Mar 28;18(4). pii: E716. doi: 10.3390/ijms18040716.


High folic acid diet enhances tumour growth in PyMT-induced breast cancer.

Hansen MF, Jensen SØ, Füchtbauer EM, Martensen PM.

Br J Cancer. 2017 Mar 14;116(6):752-761. doi: 10.1038/bjc.2017.11. Epub 2017 Feb 2.


The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection.

Hussain T, Shah SZ, Zhao D, Sreevatsan S, Zhou X.

Cell Commun Signal. 2016 Dec 1;14(1):29. Review.


Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation.

Kiesel BF, Parise RA, Guo J, Huryn DM, Johnston PA, Colombo R, Sen M, Grandis JR, Beumer JH, Eiseman JL.

Cancer Chemother Pharmacol. 2016 Dec;78(6):1225-1235. Epub 2016 Oct 24.


Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling.

Xu BQ, Fu ZG, Meng Y, Wu XQ, Wu B, Xu L, Jiang JL, Li L, Chen ZN.

Oncotarget. 2016 Sep 20;7(38):62177-62193. doi: 10.18632/oncotarget.11405.


Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors.

LaPorte MG, Wang Z, Colombo R, Garzan A, Peshkov VA, Liang M, Johnston PA, Schurdak ME, Sen M, Camarco DP, Hua Y, Pollock NI, Lazo JS, Grandis JR, Wipf P, Huryn DM.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3581-5. doi: 10.1016/j.bmcl.2016.06.017. Epub 2016 Jun 9.


SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer.

Zhou Z, Wang M, Li J, Xiao M, Chin YE, Cheng J, Yeh ET, Yang J, Yi J.

Oncogene. 2016 Nov 10;35(45):5826-5838. doi: 10.1038/onc.2016.124. Epub 2016 May 16.


Salinomycin exerts anti-angiogenic and anti-tumorigenic activities by inhibiting vascular endothelial growth factor receptor 2-mediated angiogenesis.

Li T, Liu X, Shen Q, Yang W, Huo Z, Liu Q, Jiao H, Chen J.

Oncotarget. 2016 May 3;7(18):26580-92. doi: 10.18632/oncotarget.8555.


Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma.

Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ.

Oncotarget. 2016 May 3;7(18):26307-30. doi: 10.18632/oncotarget.8368.


RY10-4 Inhibits the Proliferation of Human Hepatocellular Cancer HepG2 Cells by Inducing Apoptosis In Vitro and In Vivo.

Zhang X, Wang Y, Han S, Xiang H, Peng Y, Wu Y, Pan S, Zhang Y, Ruan J.

PLoS One. 2016 Mar 14;11(3):e0151679. doi: 10.1371/journal.pone.0151679. eCollection 2016.


Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling.

Wu X, Tang W, Marquez RT, Li K, Highfill CA, He F, Lian J, Lin J, Fuchs JR, Ji M, Li L, Xu L.

Oncotarget. 2016 Mar 8;7(10):11708-23. doi: 10.18632/oncotarget.7336.


Overexpression of STAT3/pSTAT3 was associated with poor prognosis in gastric cancer: a meta-analysis.

He S, Liao G, Liu Y, Huang L, Kang M, Chen L.

Int J Clin Exp Med. 2015 Nov 15;8(11):20014-23. eCollection 2015.


Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling.

Zhu F, Dai C, Fu Y, Loo JF, Xia D, Gao SP, Ma Z, Chen Z.

Oncotarget. 2016 Feb 23;7(8):9462-76. doi: 10.18632/oncotarget.7051.

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