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Items: 1 to 20 of 34


Mechanisms of aging-related proteinopathies in Caenorhabditis elegans.

Kim DK, Kim TH, Lee SJ.

Exp Mol Med. 2016 Oct 7;48(10):e263. doi: 10.1038/emm.2016.109. Review.


Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease.

Wang X, Cao M, Dong Y.

Oncotarget. 2016 Aug 23;7(34):54183-54193. doi: 10.18632/oncotarget.10857.


RNA Granules and Diseases: A Case Study of Stress Granules in ALS and FTLD.

Fan AC, Leung AK.

Adv Exp Med Biol. 2016;907:263-96. doi: 10.1007/978-3-319-29073-7_11.


Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases.

Chen X, Barclay JW, Burgoyne RD, Morgan A.

Chem Cent J. 2015 Nov 26;9:65. doi: 10.1186/s13065-015-0143-y. eCollection 2015. Review.


Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression.

Chen X, McCue HV, Wong SQ, Kashyap SS, Kraemer BC, Barclay JW, Burgoyne RD, Morgan A.

Mol Neurodegener. 2015 Sep 29;10:51. doi: 10.1186/s13024-015-0046-3. Erratum in: Mol Neurodegener. 2015;10:54.


The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.

Salazar DA, Butler VJ, Argouarch AR, Hsu TY, Mason A, Nakamura A, McCurdy H, Cox D, Ng R, Pan G, Seeley WW, Miller BL, Kao AW.

J Neurosci. 2015 Jun 24;35(25):9315-28. doi: 10.1523/JNEUROSCI.4808-14.2015.


Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription.

Periz G, Lu J, Zhang T, Kankel MW, Jablonski AM, Kalb R, McCampbell A, Wang J.

PLoS Biol. 2015 Apr 2;13(4):e1002114. doi: 10.1371/journal.pbio.1002114. eCollection 2015 Apr.


Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia.

Xia Q, Hu Q, Wang H, Yang H, Gao F, Ren H, Chen D, Fu C, Zheng L, Zhen X, Ying Z, Wang G.

Cell Death Dis. 2015 Mar 26;6:e1702. doi: 10.1038/cddis.2015.69.


mRNP granules. Assembly, function, and connections with disease.

Buchan JR.

RNA Biol. 2014;11(8):1019-30. doi: 10.4161/15476286.2014.972208. Review.


RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response.

Zhang T, Baldie G, Periz G, Wang J.

PLoS Genet. 2014 Oct 16;10(10):e1004693. doi: 10.1371/journal.pgen.1004693. eCollection 2014 Oct.


Longevity pathways and memory aging.

Gkikas I, Petratou D, Tavernarakis N.

Front Genet. 2014 Jun 4;5:155. doi: 10.3389/fgene.2014.00155. eCollection 2014. Review.


Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans.

Therrien M, Parker JA.

Front Genet. 2014 Apr 17;5:85. doi: 10.3389/fgene.2014.00085. eCollection 2014. Review.


A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.

Long OS, Benson JA, Kwak JH, Luke CJ, Gosai SJ, O'Reilly LP, Wang Y, Li J, Vetica AC, Miedel MT, Stolz DB, Watkins SC, Züchner S, Perlmutter DH, Silverman GA, Pak SC.

Hum Mol Genet. 2014 Oct 1;23(19):5109-22. doi: 10.1093/hmg/ddu235. Epub 2014 May 16.


HSF1 protects neurons through a novel trimerization- and HSP-independent mechanism.

Verma P, Pfister JA, Mallick S, D'Mello SR.

J Neurosci. 2014 Jan 29;34(5):1599-612. doi: 10.1523/JNEUROSCI.3039-13.2014.


The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans.

Estevez AO, Morgan KL, Szewczyk NJ, Gems D, Estevez M.

Neurotoxicology. 2014 Mar;41:28-43. doi: 10.1016/j.neuro.2013.12.012. Epub 2014 Jan 6.


A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity.

El-Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E.

Aging Cell. 2014 Feb;13(1):165-74. doi: 10.1111/acel.12171. Epub 2013 Nov 22.


Disease animal models of TDP-43 proteinopathy and their pre-clinical applications.

Liu YC, Chiang PM, Tsai KJ.

Int J Mol Sci. 2013 Oct 9;14(10):20079-111. doi: 10.3390/ijms141020079. Review.


Aging, protein aggregation, chaperones, and neurodegenerative disorders: mechanisms of coupling and therapeutic opportunities.

Cohen E.

Rambam Maimonides Med J. 2012 Oct 31;3(4):e0021. doi: 10.5041/RMMJ.10088. Print 2012 Oct.


Pathways to decoding the clinical potential of stress response FOXO-interaction networks for Huntington's disease: of gene prioritization and context dependence.

Parmentier F, Lejeune FX, Neri C.

Front Aging Neurosci. 2013 Jun 13;5:22. doi: 10.3389/fnagi.2013.00022. eCollection 2013.

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