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A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.

Fu Y, Mi L, Sanda M, Silverstein S, Aggarwal M, Wang D, Gupta P, Goldman R, Appella DH, Chung FL.

RSC Adv. 2014;4(8):3920-3923. doi: 10.1039/C3RA46849F.


Fatty Acid Synthesis Intermediates Represent Novel Noninvasive Biomarkers of Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate.

Singh KB, Singh SV.

Cancer Prev Res (Phila). 2017 May;10(5):279-289. doi: 10.1158/1940-6207.CAPR-17-0001. Epub 2017 Mar 14.


The andean anticancer herbal product BIRM causes destabilization of androgen receptor and induces caspase-8 mediated-apoptosis in prostate cancer.

Shamaladevi N, Araki S, Lyn DA, Ayyathurai R, Gao J, Lokeshwar VB, Navarrete H, Lokeshwar BL.

Oncotarget. 2016 Dec 20;7(51):84201-84213. doi: 10.18632/oncotarget.12393.


Epigenetic modulators as therapeutic targets in prostate cancer.

Graça I, Pereira-Silva E, Henrique R, Packham G, Crabb SJ, Jerónimo C.

Clin Epigenetics. 2016 Sep 15;8:98. doi: 10.1186/s13148-016-0264-8. eCollection 2016. Review.


Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate.

Sehrawat A, Croix CS, Baty CJ, Watkins S, Tailor D, Singh RP, Singh SV.

Mitochondrion. 2016 Sep;30:67-77. doi: 10.1016/j.mito.2016.06.006. Epub 2016 Jun 30.


Withaferin A inhibits in vivo growth of breast cancer cells accelerated by Notch2 knockdown.

Kim SH, Hahm ER, Arlotti JA, Samanta SK, Moura MB, Thorne SH, Shuai Y, Anderson CJ, White AG, Lokshin A, Lee J, Singh SV.

Breast Cancer Res Treat. 2016 May;157(1):41-54. doi: 10.1007/s10549-016-3795-y. Epub 2016 Apr 21.


Soy-Based Multiple Amino Acid Oral Supplementation Increases the Anti-Sarcoma Effect of Cyclophosphamide.

Yao CA, Chen CC, Wang NP, Chien CT.

Nutrients. 2016 Apr 1;8(4):192. doi: 10.3390/nu8040192.


Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like Traits.

Vyas AR, Moura MB, Hahm ER, Singh KB, Singh SV.

J Cell Biochem. 2016 Nov;117(11):2482-95. doi: 10.1002/jcb.25541. Epub 2016 May 26.


Benzyl Isothiocyanate Inhibits Prostate Cancer Development in the Transgenic Adenocarcinoma Mouse Prostate (TRAMP) Model, Which Is Associated with the Induction of Cell Cycle G1 Arrest.

Cho HJ, Lim DY, Kwon GT, Kim JH, Huang Z, Song H, Oh YS, Kang YH, Lee KW, Dong Z, Park JH.

Int J Mol Sci. 2016 Feb 22;17(2):264. doi: 10.3390/ijms17020264.


Calcium homeostasis and ER stress in control of autophagy in cancer cells.

Kania E, Pająk B, Orzechowski A.

Biomed Res Int. 2015;2015:352794. doi: 10.1155/2015/352794. Epub 2015 Mar 3. Review.


Roles of autophagy induced by natural compounds in prostate cancer.

Naponelli V, Modernelli A, Bettuzzi S, Rizzi F.

Biomed Res Int. 2015;2015:121826. doi: 10.1155/2015/121826. Epub 2015 Mar 3. Review.


CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells.

Sakao K, Vyas AR, Chinni SR, Amjad AI, Parikh R, Singh SV.

Cancer Prev Res (Phila). 2015 May;8(5):365-74. doi: 10.1158/1940-6207.CAPR-14-0386. Epub 2015 Feb 23.


Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms.

Gupta P, Wright SE, Kim SH, Srivastava SK.

Biochim Biophys Acta. 2014 Dec;1846(2):405-24. doi: 10.1016/j.bbcan.2014.08.003. Epub 2014 Aug 23. Review.


Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells.

Hahm ER, Sakao K, Singh SV.

Prostate. 2014 Sep;74(12):1209-21. doi: 10.1002/pros.22837. Epub 2014 Jul 7.


Mammary cancer chemoprevention by withaferin A is accompanied by in vivo suppression of self-renewal of cancer stem cells.

Kim SH, Singh SV.

Cancer Prev Res (Phila). 2014 Jul;7(7):738-47. doi: 10.1158/1940-6207.CAPR-13-0445. Epub 2014 May 13.


Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors.

Lee J, Hahm ER, Marcus AI, Singh SV.

Mol Carcinog. 2015 Jun;54(6):417-29. doi: 10.1002/mc.22110. Epub 2013 Nov 30.


Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal model.

Stan SD, Singh SV, Whitcomb DC, Brand RE.

Nutr Cancer. 2014;66(4):747-55. doi: 10.1080/01635581.2013.795979. Epub 2013 Nov 6.


Chemoprevention of prostate cancer by d,l-sulforaphane is augmented by pharmacological inhibition of autophagy.

Vyas AR, Hahm ER, Arlotti JA, Watkins S, Stolz DB, Desai D, Amin S, Singh SV.

Cancer Res. 2013 Oct 1;73(19):5985-95. doi: 10.1158/0008-5472.CAN-13-0755. Epub 2013 Aug 6.


Metabolic alterations in mammary cancer prevention by withaferin A in a clinically relevant mouse model.

Hahm ER, Lee J, Kim SH, Sehrawat A, Arlotti JA, Shiva SS, Bhargava R, Singh SV.

J Natl Cancer Inst. 2013 Aug 7;105(15):1111-22. doi: 10.1093/jnci/djt153. Epub 2013 Jul 2.

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