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PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages.

Guentsch A, Beneke A, Swain L, Farhat K, Nagarajan S, Wielockx B, Raithatha K, Dudek J, Rehling P, Zieseniss A, Jatho A, Chong M, Santos CX, Shah AM, Katschinski DM.

Mol Cell Biol. 2016 Dec 19;37(1). pii: e00236-16.


Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges.

Harnoss JM, Strowitzki MJ, Radhakrishnan P, Platzer LK, Harnoss JC, Hank T, Cai J, Ulrich A, Schneider M.

Hypoxia (Auckl). 2015 Jan 30;3:1-14. Review.


Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism.

Yang M, Su H, Soga T, Kranc KR, Pollard PJ.

Hypoxia (Auckl). 2014 Aug 30;2:127-142. Review.


HIF-mediated innate immune responses: cell signaling and therapeutic implications.

Harris AJ, Thompson AR, Whyte MK, Walmsley SR.

Hypoxia (Auckl). 2014 May 24;2:47-58. Review.


HIF1α and metabolic reprogramming in inflammation.

Corcoran SE, O'Neill LA.

J Clin Invest. 2016 Oct 3;126(10):3699-3707. doi: 10.1172/JCI84431.


Hypoxia-dependent regulation of inflammatory pathways in immune cells.

Taylor CT, Doherty G, Fallon PG, Cummins EP.

J Clin Invest. 2016 Oct 3;126(10):3716-3724. doi: 10.1172/JCI84433.


Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma.

Seumois G, Zapardiel-Gonzalo J, White B, Singh D, Schulten V, Dillon M, Hinz D, Broide DH, Sette A, Peters B, Vijayanand P.

J Immunol. 2016 Jul 15;197(2):655-64. doi: 10.4049/jimmunol.1600397.


Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression.

Jones R, McDonald KE, Willson JA, Ghesquière B, Sammut D, Daniel E, Harris AJ, Lewis A, Thompson AA, Dickinson RS, Plant T, Murphy F, Sadiku P, Keevil BG, Carmeliet P, Whyte MK, Newell-Price J, Walmsley SR.

Blood. 2016 May 26;127(21):2641-4. doi: 10.1182/blood-2016-02-696922. No abstract available.


NF-κB and HIF crosstalk in immune responses.

D'Ignazio L, Bandarra D, Rocha S.

FEBS J. 2016 Feb;283(3):413-24. doi: 10.1111/febs.13578. Review.


Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models.

Elks PM, Renshaw SA, Meijer AH, Walmsley SR, van Eeden FJ.

Dis Model Mech. 2015 Nov;8(11):1349-60. doi: 10.1242/dmm.021865. Review.


Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia.

Holdstock L, Meadowcroft AM, Maier R, Johnson BM, Jones D, Rastogi A, Zeig S, Lepore JJ, Cobitz AR.

J Am Soc Nephrol. 2016 Apr;27(4):1234-44. doi: 10.1681/ASN.2014111139.


Molecular mechanisms of ischemic preconditioning in the kidney.

Kapitsinou PP, Haase VH.

Am J Physiol Renal Physiol. 2015 Nov 15;309(10):F821-34. doi: 10.1152/ajprenal.00224.2015. Review.


Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa.

Campbell EL, Colgan SP.

J Leukoc Biol. 2015 Oct;98(4):517-22. doi: 10.1189/jlb.3MR1114-556R. Review.


Involvement of hypoxia-inducible factors in the dysregulation of oxygen homeostasis in sepsis.

Hirota K.

Cardiovasc Hematol Disord Drug Targets. 2015;15(1):29-40. Review.


The regulation of pulmonary inflammation by the hypoxia-inducible factor-hydroxylase oxygen-sensing pathway.

Whyte MK, Walmsley SR.

Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S271-6. doi: 10.1513/AnnalsATS.201403-108AW. Review.


HIF transcription factors, inflammation, and immunity.

Palazon A, Goldrath AW, Nizet V, Johnson RS.

Immunity. 2014 Oct 16;41(4):518-28. doi: 10.1016/j.immuni.2014.09.008. Review.


Phagocyte-myocyte interactions and consequences during hypoxic wound healing.

Zhang S, Dehn S, DeBerge M, Rhee KJ, Hudson B, Thorp EB.

Cell Immunol. 2014 Sep-Oct;291(1-2):65-73. doi: 10.1016/j.cellimm.2014.04.006. Review.


Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein.

Place TL, Domann FE.

Hypoxia (Auckl). 2013 Oct 1;2013(1):13-17.


Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MK, Walmsley SR.

Blood. 2014 Jan 16;123(3):366-76. doi: 10.1182/blood-2013-05-500207.

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