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Items: 1 to 20 of 26


11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes.

Peng K, Pan Y, Li J, Khan Z, Fan M, Yin H, Tong C, Zhao Y, Liang G, Zheng C.

Sci Rep. 2016 Nov 14;6:37160. doi: 10.1038/srep37160.


IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity.

Shahid M, Javed AA, Chandra D, Ramsey HE, Shah D, Khan MF, Zhao L, Wu MX.

Sci Rep. 2016 Apr 11;6:24135. doi: 10.1038/srep24135.


Stress kinases in the modulation of metabolism and energy balance.

Manieri E, Sabio G.

J Mol Endocrinol. 2015 Oct;55(2):R11-22. doi: 10.1530/JME-15-0146. Review.


High-fat load: mechanism(s) of insulin resistance in skeletal muscle.

Lark DS, Fisher-Wellman KH, Neufer PD.

Int J Obes Suppl. 2012 Dec;2(Suppl 2):S31-S36.


CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPARγ.

Li R, Xu X, Chen C, Wang Y, Gruzdev A, Zeldin DC, Wang DW.

Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E270-82. doi: 10.1152/ajpendo.00118.2014.


Adropin is a brain membrane-bound protein regulating physical activity via the NB-3/Notch signaling pathway in mice.

Wong CM, Wang Y, Lee JT, Huang Z, Wu D, Xu A, Lam KS.

J Biol Chem. 2014 Sep 12;289(37):25976-86. doi: 10.1074/jbc.M114.576058.


A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity.

Hernandez ED, Lee SJ, Kim JY, Duran A, Linares JF, Yajima T, Müller TD, Tschöp MH, Smith SR, Diaz-Meco MT, Moscat J.

Cell Metab. 2014 Sep 2;20(3):499-511. doi: 10.1016/j.cmet.2014.06.008.


Intrinsic aerobic capacity impacts susceptibility to acute high-fat diet-induced hepatic steatosis.

Morris EM, Jackman MR, Johnson GC, Liu TW, Lopez JL, Kearney ML, Fletcher JA, Meers GM, Koch LG, Britton SL, Rector RS, Ibdah JA, MacLean PS, Thyfault JP.

Am J Physiol Endocrinol Metab. 2014 Aug 15;307(4):E355-64. doi: 10.1152/ajpendo.00093.2014.


Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: Role of adipokines.

Hui E, Xu A, Bo Yang H, Lam KS.

J Diabetes Investig. 2013 Sep 13;4(5):413-25. doi: 10.1111/jdi.12093. Review.


Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation.

Peverill W, Powell LW, Skoien R.

Int J Mol Sci. 2014 May 14;15(5):8591-638. doi: 10.3390/ijms15058591. Review.


Hepatic ERK activity plays a role in energy metabolism.

Jiao P, Feng B, Li Y, He Q, Xu H.

Mol Cell Endocrinol. 2013 Aug 15;375(1-2):157-66. doi: 10.1016/j.mce.2013.05.021.


Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice.

Xu C, Bai B, Fan P, Cai Y, Huang B, Law IK, Liu L, Xu A, Tung C, Li X, Siu FM, Che CM, Vanhoutte PM, Wang Y.

Am J Transl Res. 2013 May 24;5(4):412-26.


Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance.

Lee BC, Lee J.

Biochim Biophys Acta. 2014 Mar;1842(3):446-62. doi: 10.1016/j.bbadis.2013.05.017. Review.


An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.

Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR.

Nat Med. 2013 Mar;19(3):313-21. doi: 10.1038/nm.3082.


Pathophysiology of NASH: perspectives for a targeted treatment.

Marra F, Lotersztajn S.

Curr Pharm Des. 2013;19(29):5250-69.


In vivo JNK activation in pancreatic β-cells leads to glucose intolerance caused by insulin resistance in pancreas.

Lanuza-Masdeu J, Arévalo MI, Vila C, Barberà A, Gomis R, Caelles C.

Diabetes. 2013 Jul;62(7):2308-17. doi: 10.2337/db12-1097.


Implication of inflammatory signaling pathways in obesity-induced insulin resistance.

Tanti JF, Ceppo F, Jager J, Berthou F.

Front Endocrinol (Lausanne). 2013 Jan 8;3:181. doi: 10.3389/fendo.2012.00181.


Progression from high insulin resistance to type 2 diabetes does not entail additional visceral adipose tissue inflammation.

Barbarroja N, Lopez-Pedrera C, Garrido-Sanchez L, Mayas MD, Oliva-Olivera W, Bernal-Lopez MR, El Bekay R, Tinahones FJ.

PLoS One. 2012;7(10):e48155. doi: 10.1371/journal.pone.0048155.


Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver.

Yang L, Wu D, Wang X, Cederbaum AI.

Free Radic Biol Med. 2012 Sep 1;53(5):1170-80. doi: 10.1016/j.freeradbiomed.2012.06.029.

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