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Items: 1 to 20 of 25


Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.

Uhrlaub JL, Pulko V, DeFilippis VR, Broeckel R, Streblow DN, Coleman GD, Park BS, Lindo JF, Vickers I, Anzinger JJ, Nikolich-Žugich J.

PLoS Pathog. 2016 Oct 13;12(10):e1005891. doi: 10.1371/journal.ppat.1005891. eCollection 2016 Oct.


Modeling the dynamics of neonatal CD8+ T-cell responses.

Reynaldi A, Smith NL, Schlub TE, Venturi V, Rudd BD, Davenport MP.

Immunol Cell Biol. 2016 Oct;94(9):838-848. doi: 10.1038/icb.2016.47. Epub 2016 May 4.


Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice.

Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB, Katsikis PD.

J Immunol. 2016 Mar 15;196(6):2602-13. doi: 10.4049/jimmunol.1502126. Epub 2016 Feb 12.


The Neonatal CD8+ T Cell Repertoire Rapidly Diversifies during Persistent Viral Infection.

Venturi V, Nzingha K, Amos TG, Charles WC, Dekhtiarenko I, Cicin-Sain L, Davenport MP, Rudd BD.

J Immunol. 2016 Feb 15;196(4):1604-16. doi: 10.4049/jimmunol.1501867. Epub 2016 Jan 13.


MicroRNAs and Their Targets Are Differentially Regulated in Adult and Neonatal Mouse CD8+ T Cells.

Wissink EM, Smith NL, Spektor R, Rudd BD, Grimson A.

Genetics. 2015 Nov;201(3):1017-30. doi: 10.1534/genetics.115.179176. Epub 2015 Sep 28.


αβ T cell receptors as predictors of health and disease.

Attaf M, Huseby E, Sewell AK.

Cell Mol Immunol. 2015 Jul;12(4):391-9. doi: 10.1038/cmi.2014.134. Epub 2015 Jan 26. Review.


Narrowing of human influenza A virus-specific T cell receptor α and β repertoires with increasing age.

Gil A, Yassai MB, Naumov YN, Selin LK.

J Virol. 2015 Apr;89(8):4102-16. doi: 10.1128/JVI.03020-14. Epub 2015 Jan 21.


Vaccination and heterologous immunity: educating the immune system.

Gil A, Kenney LL, Mishra R, Watkin LB, Aslan N, Selin LK.

Trans R Soc Trop Med Hyg. 2015 Jan;109(1):62-9. doi: 10.1093/trstmh/tru198. Review.


Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells.

Cohen SB, Smith NL, McDougal C, Pepper M, Shah S, Yap GS, Acha-Orbea H, Jiang A, Clausen BE, Rudd BD, Denkers EY.

J Immunol. 2015 Jan 1;194(1):210-22.


Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells.

Lanzer KG, Johnson LL, Woodland DL, Blackman MA.

Immun Ageing. 2014 May 13;11:9. doi: 10.1186/1742-4933-11-9. eCollection 2014.


Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.

Smith NL, Wissink E, Wang J, Pinello JF, Davenport MP, Grimson A, Rudd BD.

J Immunol. 2014 Jul 1;193(1):177-84. doi: 10.4049/jimmunol.1400553. Epub 2014 May 21.


A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging.

Johnson PL, Goronzy JJ, Antia R.

Immunology. 2014 Jun;142(2):167-75. doi: 10.1111/imm.12244. Review.


Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses.

Rudd BD, Venturi V, Smith NL, Nzingha K, Goldberg EL, Li G, Nikolich-Zugich J, Davenport MP.

PLoS Pathog. 2013 Sep;9(9):e1003572. doi: 10.1371/journal.ppat.1003572. Epub 2013 Sep 12.


Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age.

Johnson PL, Yates AJ, Goronzy JJ, Antia R.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21432-7. doi: 10.1073/pnas.1209283110. Epub 2012 Dec 10.


Use it or lose it: establishment and persistence of T cell memory.

Kedzierska K, Valkenburg SA, Doherty PC, Davenport MP, Venturi V.

Front Immunol. 2012 Nov 27;3:357. doi: 10.3389/fimmu.2012.00357. eCollection 2012.


Extralymphocytic flexible immune recognition: a new angle on inflammation and aging.

Kaminski WE, Beham AW, Puellmann K.

Aging Dis. 2012 Oct;3(5):404-13. Epub 2012 Sep 19.


Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.

Smithey MJ, Li G, Venturi V, Davenport MP, Nikolich-Žugich J.

J Immunol. 2012 Dec 1;189(11):5356-66. doi: 10.4049/jimmunol.1201867. Epub 2012 Oct 19.


Age-related changes in CD8 T cell homeostasis and immunity to infection.

Nikolich-Žugich J, Li G, Uhrlaub JL, Renkema KR, Smithey MJ.

Semin Immunol. 2012 Oct;24(5):356-64. doi: 10.1016/j.smim.2012.04.009. Epub 2012 May 1. Review.


Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population.

Reber AJ, Chirkova T, Kim JH, Cao W, Biber R, Shay DK, Sambhara S.

Aging Dis. 2012 Feb;3(1):68-90. Epub 2011 Sep 30.


Early priming minimizes the age-related immune compromise of CD8⁺ T cell diversity and function.

Valkenburg SA, Venturi V, Dang TH, Bird NL, Doherty PC, Turner SJ, Davenport MP, Kedzierska K.

PLoS Pathog. 2012 Feb;8(2):e1002544. doi: 10.1371/journal.ppat.1002544. Epub 2012 Feb 23. Erratum in: PLoS Pathog. 2012 Mar;8(3). doi: 10.1371/annotation/e142f9de-7f30-4759-bda1-a651e86d5ba6.

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