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Retrospective Evaluation of Metformin and/or Metformin Plus a New Polysaccharide Complex in Treating Severe Hyperinsulinism and Insulin Resistance in Obese Children and Adolescents with Metabolic Syndrome.

Stagi S, Ricci F, Bianconi M, Sammarco MA, Municchi G, Toni S, Lenzi L, Verrotti A, de Martino M.

Nutrients. 2017 May 20;9(5). pii: E524. doi: 10.3390/nu9050524.


Effect of folic acid and metformin on insulin resistance and inflammatory factors of obese children and adolescents.

Dehkordi EH, Sattari F, Khoshdel A, Kasiri K.

J Res Med Sci. 2016 Sep 1;21:71. eCollection 2016.


Clinical Pharmacokinetics and Pharmacodynamics of Antihyperglycemic Medications in Children and Adolescents with Type 2 Diabetes Mellitus.

Akhlaghi F, Matson KL, Mohammadpour AH, Kelly M, Karimani A.

Clin Pharmacokinet. 2017 Jun;56(6):561-571. doi: 10.1007/s40262-016-0472-6. Review.


Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial.

van der Aa MP, Elst MA, van de Garde EM, van Mil EG, Knibbe CA, van der Vorst MM.

Nutr Diabetes. 2016 Aug 29;6(8):e228. doi: 10.1038/nutd.2016.37.


A longitudinal study of serum insulin and insulin resistance as predictors of weight and body fat gain in African American and Caucasian children.

Sedaka NM, Olsen CH, Yannai LE, Stutzman WE, Krause AJ, Sherafat-Kazemzadeh R, Condarco TA, Brady SM, Demidowich AP, Reynolds JC, Yanovski SZ, Hubbard VS, Yanovski JA.

Int J Obes (Lond). 2017 Jan;41(1):61-70. doi: 10.1038/ijo.2016.145. Epub 2016 Aug 18.


Evaluation of differential effects of metformin treatment in obese children according to pubertal stage and genetic variations: study protocol for a randomized controlled trial.

Pastor-Villaescusa B, Caballero-Villarraso J, Cañete MD, Hoyos R, Maldonado J, Bueno G, Leis R, Gil Á, Cañete R, Aguilera CM.

Trials. 2016 Jul 18;17(1):323. doi: 10.1186/s13063-016-1403-4.


Effects of SLC22A1 Polymorphisms on Metformin-Induced Reductions in Adiposity and Metformin Pharmacokinetics in Obese Children With Insulin Resistance.

Sam WJ, Roza O, Hon YY, Alfaro RM, Calis KA, Reynolds JC, Yanovski JA.

J Clin Pharmacol. 2017 Feb;57(2):219-229. doi: 10.1002/jcph.796. Epub 2016 Aug 23.


Hyperglycemia-Mediated Oxidative Stress Increases Pulmonary Vascular Permeability.

Clemmer JS, Xiang L, Lu S, Mittwede PN, Hester RL.

Microcirculation. 2016 Apr;23(3):221-9. doi: 10.1111/micc.12267.


Pressure To Be Thin and Insulin Sensitivity Among Adolescents.

Schvey NA, Shomaker LB, Kelly NR, Pickworth CK, Cassidy O, Galescu O, Demidowich AP, Brady SM, Tanofsky-Kraff M, Yanovski JA.

J Adolesc Health. 2016 Jan;58(1):104-10. doi: 10.1016/j.jadohealth.2015.09.010.


Predictors of weight-loss response with glucagon-like peptide-1 receptor agonist treatment among adolescents with severe obesity.

Nathan BM, Rudser KD, Abuzzahab MJ, Fox CK, Coombes BJ, Bomberg EM, Kelly AS.

Clin Obes. 2016 Feb;6(1):73-8. doi: 10.1111/cob.12128. Epub 2015 Dec 18.


Diabetes, metformin and incidence of and death from invasive cancer in postmenopausal women: Results from the women's health initiative.

Gong Z, Aragaki AK, Chlebowski RT, Manson JE, Rohan TE, Chen C, Vitolins MZ, Tinker LF, LeBlanc ES, Kuller LH, Hou L, LaMonte MJ, Luo J, Wactawski-Wende J.

Int J Cancer. 2016 Apr 15;138(8):1915-27. doi: 10.1002/ijc.29944. Epub 2015 Dec 15.


In Vitro and In Vivo Effects of Metformin on Osteopontin Expression in Mice Adipose-Derived Multipotent Stromal Cells and Adipose Tissue.

Śmieszek A, Basińska K, Chrząstek K, Marycz K.

J Diabetes Res. 2015;2015:814896. doi: 10.1155/2015/814896. Epub 2015 Apr 30.


Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits.

Adler-Wailes DC, Alberobello AT, Ma X, Hugendubler L, Stern EA, Mou Z, Han JC, Kim PW, Sumner AE, Yanovski JA, Mueller E.

Int J Obes (Lond). 2015 Jun;39(6):888-92. doi: 10.1038/ijo.2015.17. Epub 2015 Feb 12.


Effects of metformin on energy intake and satiety in obese children.

Adeyemo MA, McDuffie JR, Kozlosky M, Krakoff J, Calis KA, Brady SM, Yanovski JA.

Diabetes Obes Metab. 2015 Apr;17(4):363-70. doi: 10.1111/dom.12426. Epub 2015 Jan 11.


Addressing prediabetes in childhood obesity treatment programs: support from research and current practice.

Haemer MA, Grow HM, Fernandez C, Lukasiewicz GJ, Rhodes ET, Shaffer LA, Sweeney B, Woolford SJ, Estrada E.

Child Obes. 2014 Aug;10(4):292-303. doi: 10.1089/chi.2013.0158. Epub 2014 Jul 23. Review.


Obese and overweight children and adolescents: an algorithmic clinical approach.

Alizadeh Z, Khosravi S, Borna S.

Iran J Pediatr. 2013 Dec;23(6):621-31.


An evolving scientific basis for the prevention and treatment of pediatric obesity.

Katzmarzyk PT, Barlow S, Bouchard C, Catalano PM, Hsia DS, Inge TH, Lovelady C, Raynor H, Redman LM, Staiano AE, Spruijt-Metz D, Symonds ME, Vickers M, Wilfley D, Yanovski JA.

Int J Obes (Lond). 2014 Jul;38(7):887-905. doi: 10.1038/ijo.2014.49. Epub 2014 Mar 25. Review.


Unplanned medication discontinuation as a potential pharmacovigilance signal: a nested young person cohort study.

Sun AP, Kirby B, Black C, Helms PJ, Bennie M, McLay JS.

BMC Pharmacol Toxicol. 2014 Mar 4;15:11. doi: 10.1186/2050-6511-15-11.


Treatment strategies to prevent renal damage in hypertensive children.

Czarniak P, Zurowska A.

Curr Hypertens Rep. 2014 Apr;16(4):423. doi: 10.1007/s11906-014-0423-2. Review.

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