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Items: 1 to 20 of 55

1.

Reciprocal regulation of γ-globin expression by exo-miRNAs: Relevance to γ-globin silencing in β-thalassemia major.

Sun KT, Huang YN, Palanisamy K, Chang SS, Wang IK, Wu KH, Chen P, Peng CT, Li CY.

Sci Rep. 2017 Mar 16;7(1):202. doi: 10.1038/s41598-017-00150-7.

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3.

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.

Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan GC, Lettre G, Bauer DE, Orkin SH.

Nat Genet. 2017 Apr;49(4):625-634. doi: 10.1038/ng.3793. Epub 2017 Feb 20.

PMID:
28218758
4.

Hyperglycaemia-induced reciprocal changes in miR-30c and PAI-1 expression in platelets.

Luo M, Li R, Ren M, Chen N, Deng X, Tan X, Li Y, Zeng M, Yang Y, Wan Q, Wu J.

Sci Rep. 2016 Nov 7;6:36687. doi: 10.1038/srep36687.

5.

Emerging cellular and gene therapies for congenital anemias.

Ludwig LS, Khajuria RK, Sankaran VG.

Am J Med Genet C Semin Med Genet. 2016 Dec;172(4):332-348. doi: 10.1002/ajmg.c.31529. Epub 2016 Oct 28. Review.

PMID:
27792859
6.

Normal hematologic parameters and fetal hemoglobin silencing with heterozygous IKZF1 mutations.

Abdulhay N, Fiorini C, Kumánovics A, Sun AA, Hansen-Rejali J, Voelkerding KV, Rosenzweig SD, Hill HR, Sankaran VG.

Blood. 2016 Oct 20;128(16):2100-2103. doi: 10.1182/blood-2016-08-731943. Epub 2016 Aug 31. No abstract available.

PMID:
27581358
7.

A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.

Vathipadiekal V, Farrell JJ, Wang S, Edward HL, Shappell H, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Simkin I, Farrer LA, Jiang Z, Luo HY, Huang S, Mostoslavsky G, Murphy GJ, Patra PK, Chui DH, Alsultan A, Al-Ali AK, Sebastiani P, Steinberg MH.

Am J Hematol. 2016 Nov;91(11):1118-1122. doi: 10.1002/ajh.24527. Epub 2016 Aug 22.

PMID:
27501013
8.

MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia.

Xie Y, Li W, Feng J, Wu T, Li J.

Mol Med Rep. 2016 Sep;14(3):2503-10. doi: 10.3892/mmr.2016.5578. Epub 2016 Jul 29.

9.

Hemoglobin genetics: recent contributions of GWAS and gene editing.

Smith EC, Orkin SH.

Hum Mol Genet. 2016 Oct 1;25(R2):R99-R105. Epub 2016 Jun 23. Review.

PMID:
27340226
10.

Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion.

Capellera-Garcia S, Pulecio J, Dhulipala K, Siva K, Rayon-Estrada V, Singbrant S, Sommarin MN, Walkley CR, Soneji S, Karlsson G, Raya Á, Sankaran VG, Flygare J.

Cell Rep. 2016 Jun 14;15(11):2550-62. doi: 10.1016/j.celrep.2016.05.027. Epub 2016 Jun 2.

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12.

Minireview: Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: Early steps to precision medicine.

Goodman SR, Pace BS, Hansen KC, D'alessandro A, Xia Y, Daescu O, Glatt SJ.

Exp Biol Med (Maywood). 2016 Apr;241(7):772-81. doi: 10.1177/1535370216640150. Epub 2016 Mar 27.

13.

Original Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells.

Ward CM, Li B, Pace BS.

Exp Biol Med (Maywood). 2016 Apr;241(7):719-29. doi: 10.1177/1535370216636725. Epub 2016 Mar 2.

14.

MicroRNA Expression in β-Thalassemia and Sickle Cell Disease: A Role in The Induction of Fetal Hemoglobin.

Saki N, Abroun S, Soleimani M, Kavianpour M, Shahjahani M, Mohammadi-Asl J, Hajizamani S.

Cell J. 2016 Winter;17(4):583-92. Epub 2016 Jan 17. Review.

15.

Advances in understanding erythropoiesis: evolving perspectives.

Nandakumar SK, Ulirsch JC, Sankaran VG.

Br J Haematol. 2016 Apr;173(2):206-18. doi: 10.1111/bjh.13938. Epub 2016 Feb 5. Review.

16.

MiR-218 Inhibits Erythroid Differentiation and Alters Iron Metabolism by Targeting ALAS2 in K562 Cells.

Li Y, Liu S, Sun H, Yang Y, Qi H, Ding N, Zheng J, Dong X, Qu H, Zhang Z, Fang X.

Int J Mol Sci. 2015 Nov 26;16(12):28156-68. doi: 10.3390/ijms161226088.

17.

Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells.

Giani FC, Fiorini C, Wakabayashi A, Ludwig LS, Salem RM, Jobaliya CD, Regan SN, Ulirsch JC, Liang G, Steinberg-Shemer O, Guo MH, Esko T, Tong W, Brugnara C, Hirschhorn JN, Weiss MJ, Zon LI, Chou ST, French DL, Musunuru K, Sankaran VG.

Cell Stem Cell. 2016 Jan 7;18(1):73-8. doi: 10.1016/j.stem.2015.09.015. Epub 2015 Oct 22.

18.

Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease.

Pace BS, Liu L, Li B, Makala LH.

Exp Biol Med (Maywood). 2015 Aug;240(8):1050-64. doi: 10.1177/1535370215596859. Review.

19.

MicroRNA-15/16 Antagonizes Myb To Control NK Cell Maturation.

Sullivan RP, Leong JW, Schneider SE, Ireland AR, Berrien-Elliott MM, Singh A, Schappe T, Jewell BA, Sexl V, Fehniger TA.

J Immunol. 2015 Sep 15;195(6):2806-17. doi: 10.4049/jimmunol.1500949. Epub 2015 Aug 12.

20.

MYB controls erythroid versus megakaryocyte lineage fate decision through the miR-486-3p-mediated downregulation of MAF.

Bianchi E, Bulgarelli J, Ruberti S, Rontauroli S, Sacchi G, Norfo R, Pennucci V, Zini R, Salati S, Prudente Z, Ferrari S, Manfredini R.

Cell Death Differ. 2015 Dec;22(12):1906-21. doi: 10.1038/cdd.2015.30. Epub 2015 Apr 10.

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