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TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.

Dowling DJ, van Haren SD, Scheid A, Bergelson I, Kim D, Mancuso CJ, Foppen W, Ozonoff A, Fresh L, Theriot TB, Lackner AA, Fichorova RN, Smirnov D, Vasilakos JP, Beaurline JM, Tomai MA, Midkiff CC, Alvarez X, Blanchard JL, Gilbert MH, Aye PP, Levy O.

JCI Insight. 2017 Mar 23;2(6):e91020. doi: 10.1172/jci.insight.91020.


Increasing JAK/STAT Signaling Function of Infant CD4+ T Cells during the First Year of Life.

Dela Peña-Ponce MG, Rodriguez-Nieves J, Bernhardt J, Tuck R, Choudhary N, Mengual M, Mollan KR, Hudgens MG, Peter-Wohl S, De Paris K.

Front Pediatr. 2017 Feb 21;5:15. doi: 10.3389/fped.2017.00015. eCollection 2017.


Infants with low vaccine antibody responses have altered innate cytokine response.

Surendran N, Nicolosi T, Pichichero M.

Vaccine. 2016 Nov 11;34(47):5700-5703. doi: 10.1016/j.vaccine.2016.09.050. Epub 2016 Oct 13.


The expression and function of human CD300 receptors on blood circulating mononuclear cells are distinct in neonates and adults.

Zenarruzabeitia O, Vitallé J, García-Obregón S, Astigarraga I, Eguizabal C, Santos S, Simhadri VR, Borrego F.

Sci Rep. 2016 Sep 6;6:32693. doi: 10.1038/srep32693.


A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life.

Rahman M, Boughorbel S, Presnell S, Quinn C, Cugno C, Chaussabel D, Marr N.

F1000Res. 2016 Mar 30;5:414. doi: 10.12688/f1000research.8375.1. eCollection 2016.


Direct TLR-2 Costimulation Unmasks the Proinflammatory Potential of Neonatal CD4+ T Cells.

Sinnott BD, Park B, Boer MC, Lewinsohn DA, Lancioni CL.

J Immunol. 2016 Jul 1;197(1):68-77. doi: 10.4049/jimmunol.1501297. Epub 2016 May 18.


Neonatal Vaccination: Challenges and Intervention Strategies.

Morris MC, Surendran N.

Neonatology. 2016;109(3):161-9. doi: 10.1159/000442460. Epub 2016 Jan 13. Review.


Influenza A Virus Infection, Innate Immunity, and Childhood.

Coates BM, Staricha KL, Wiese KM, Ridge KM.

JAMA Pediatr. 2015 Oct;169(10):956-63. doi: 10.1001/jamapediatrics.2015.1387. Review.


Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults.

Lissner MM, Thomas BJ, Wee K, Tong AJ, Kollmann TR, Smale ST.

PLoS One. 2015 Jul 6;10(7):e0132061. doi: 10.1371/journal.pone.0132061. eCollection 2015.


Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus.

O'Gorman WE, Hsieh EW, Savig ES, Gherardini PF, Hernandez JD, Hansmann L, Balboni IM, Utz PJ, Bendall SC, Fantl WJ, Lewis DB, Nolan GP, Davis MM.

J Allergy Clin Immunol. 2015 Nov;136(5):1326-36. doi: 10.1016/j.jaci.2015.04.008. Epub 2015 May 30.


Genetics of transfusion recipient alloimmunization: can clues from susceptibility to autoimmunity pave the way?

Tatari-Calderone Z, Luban NL, Vukmanovic S.

Transfus Med Hemother. 2014 Nov;41(6):436-45. doi: 10.1159/000369145. Epub 2014 Nov 17. Review.


Immunity to RSV in Early-Life.

Lambert L, Sagfors AM, Openshaw PJ, Culley FJ.

Front Immunol. 2014 Sep 29;5:466. doi: 10.3389/fimmu.2014.00466. eCollection 2014. Review.


The role of environmental factors in modulating immune responses in early life.

MacGillivray DM, Kollmann TR.

Front Immunol. 2014 Sep 12;5:434. doi: 10.3389/fimmu.2014.00434. eCollection 2014. Review.


Ontogeny of myeloid cells.

De Kleer I, Willems F, Lambrecht B, Goriely S.

Front Immunol. 2014 Sep 3;5:423. doi: 10.3389/fimmu.2014.00423. eCollection 2014. Review.


Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents.

Smolen KK, Cai B, Gelinas L, Fortuno ES 3rd, Larsen M, Speert DP, Chamekh M, Cooper PJ, Esser M, Marchant A, Kollmann TR.

J Immunol. 2014 Sep 15;193(6):3003-12. doi: 10.4049/jimmunol.1400895. Epub 2014 Aug 18.


Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-amines.

Beesu M, Malladi SS, Fox LM, Jones CD, Dixit A, David SA.

J Med Chem. 2014 Sep 11;57(17):7325-41. doi: 10.1021/jm500701q. Epub 2014 Aug 20.


Age-dependent myeloid dendritic cell responses mediate resistance to la crosse virus-induced neurological disease.

Taylor KG, Woods TA, Winkler CW, Carmody AB, Peterson KE.

J Virol. 2014 Oct;88(19):11070-9. doi: 10.1128/JVI.01866-14. Epub 2014 Jul 9.


Ontogeny of early life immunity.

Dowling DJ, Levy O.

Trends Immunol. 2014 Jul;35(7):299-310. doi: 10.1016/ Epub 2014 May 28. Review.


Challenges in vaccination of neonates, infants and young children.

Pichichero ME.

Vaccine. 2014 Jun 30;32(31):3886-94. doi: 10.1016/j.vaccine.2014.05.008. Epub 2014 May 14. Review.


Maturation of innate responses to mycobacteria over the first nine months of life.

Shey MS, Nemes E, Whatney W, de Kock M, Africa H, Barnard C, van Rooyen M, Stone L, Riou C, Kollmann T, Hawn TR, Scriba TJ, Hanekom WA.

J Immunol. 2014 May 15;192(10):4833-43. doi: 10.4049/jimmunol.1400062. Epub 2014 Apr 14.

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