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Items: 1 to 20 of 23


DGK-α: A Checkpoint in Cancer-Mediated Immuno-Inhibition and Target for Immunotherapy.

Noessner E.

Front Cell Dev Biol. 2017 Mar 3;5:16. doi: 10.3389/fcell.2017.00016. eCollection 2017.


Diacylglycerol Kinases in T Cell Tolerance and Effector Function.

Chen SS, Hu Z, Zhong XP.

Front Cell Dev Biol. 2016 Nov 10;4:130. eCollection 2016. Review.


Diacylglycerol Kinases (DGKs): Novel Targets for Improving T Cell Activity in Cancer.

Riese MJ, Moon EK, Johnson BD, Albelda SM.

Front Cell Dev Biol. 2016 Oct 17;4:108. eCollection 2016. Review.


The Immunomodulatory Functions of Diacylglycerol Kinase ζ.

Singh BK, Kambayashi T.

Front Cell Dev Biol. 2016 Sep 7;4:96. doi: 10.3389/fcell.2016.00096. eCollection 2016. Review.


Diacylglycerol Kinase ζ Is a Target To Enhance NK Cell Function.

Yang E, Singh BK, Paustian AM, Kambayashi T.

J Immunol. 2016 Aug 1;197(3):934-41. doi: 10.4049/jimmunol.1600581. Epub 2016 Jun 24.


Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation.

Yang J, Zhang P, Krishna S, Wang J, Lin X, Huang H, Xie D, Gorentla B, Huang R, Gao J, Li QJ, Zhong XP.

Oncotarget. 2016 Jun 7;7(23):33744-64. doi: 10.18632/oncotarget.8164.


The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function.

Newman DK, Fu G, Adams T, Cui W, Arumugam V, Bluemn T, Riese MJ.

Sci Signal. 2016 Mar 8;9(418):ra27. doi: 10.1126/scisignal.aad1242.


TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β.

Arumugam V, Bluemn T, Wesley E, Schmidt AM, Kambayashi T, Malarkannan S, Riese MJ.

J Leukoc Biol. 2015 Nov;98(5):703-12. doi: 10.1189/jlb.2HIMA1214-578R. Epub 2015 Jul 7.


Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors.

Moon EK, Wang LC, Dolfi DV, Wilson CB, Ranganathan R, Sun J, Kapoor V, Scholler J, Puré E, Milone MC, June CH, Riley JL, Wherry EJ, Albelda SM.

Clin Cancer Res. 2014 Aug 15;20(16):4262-73. doi: 10.1158/1078-0432.CCR-13-2627. Epub 2014 Jun 11.


The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling.

Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA.

Sci Signal. 2013 Nov 26;6(303):ra102. doi: 10.1126/scisignal.2004373.


Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function.

Krishna S, Zhong XP.

Front Immunol. 2013 Jul 4;4:178. doi: 10.3389/fimmu.2013.00178. eCollection 2013.


Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.

Jun JE, Yang M, Chen H, Chakraborty AK, Roose JP.

Mol Cell Biol. 2013 Jun;33(12):2470-84. doi: 10.1128/MCB.01593-12. Epub 2013 Apr 15.


Role of diacylglycerol kinases in T cell development and function.

Krishna S, Zhong X.

Crit Rev Immunol. 2013;33(2):97-118. Review.


Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases.

Riese MJ, Wang LC, Moon EK, Joshi RP, Ranganathan A, June CH, Koretzky GA, Albelda SM.

Cancer Res. 2013 Jun 15;73(12):3566-77. doi: 10.1158/0008-5472.CAN-12-3874. Epub 2013 Apr 10.


Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.

Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP.

Sci Signal. 2013 Mar 26;6(268):ra21. doi: 10.1126/scisignal.2003848.


Diacylglycerol kinases: regulated controllers of T cell activation, function, and development.

Joshi RP, Koretzky GA.

Int J Mol Sci. 2013 Mar 26;14(4):6649-73. doi: 10.3390/ijms14046649. Review.


Cytokine profile, proliferation and phosphorylation of ERK1/2 and Akt in circulating mononuclear cells from individuals during the chronic intestinal phase of Schistosomiasis mansoni infection.

Oliveira-Prado R, Caldas IR, Teixeira-Carvalho A, Andrade MV, Fares RC, Portugal LM, Gazzinelli A, Corrêa-Oliveira R, Cunha-Melo JR.

BMC Infect Dis. 2012 Dec 27;12:380. doi: 10.1186/1471-2334-12-380.


Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation.

Kunii N, Zhao Y, Jiang S, Liu X, Scholler J, Balagopalan L, Samelson LE, Milone MC, June CH.

Hum Gene Ther. 2013 Jan;24(1):27-37. doi: 10.1089/hum.2012.130. Epub 2012 Nov 6.


Ras family of small GTPases in immunity and inflammation.

Johnson DS, Chen YH.

Curr Opin Pharmacol. 2012 Aug;12(4):458-63. doi: 10.1016/j.coph.2012.02.003. Epub 2012 Mar 7. Review.


The membrane environment can promote or suppress bistability in cell signaling networks.

Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK.

J Phys Chem B. 2012 Mar 22;116(11):3630-40. doi: 10.1021/jp2102385. Epub 2012 Mar 13.

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