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BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability.

Han J, Ruan C, Huen MSY, Wang J, Xie A, Fu C, Liu T, Huang J.

Nat Commun. 2017 Nov 13;8(1):1470. doi: 10.1038/s41467-017-01759-y.


BRCT-domain protein BRIT1 influences class switch recombination.

Yen WF, Chaudhry A, Vaidyanathan B, Yewdell WT, Pucella JN, Sharma R, Liang Y, Li K, Rudensky AY, Chaudhuri J.

Proc Natl Acad Sci U S A. 2017 Jul 19. pii: 201708211. doi: 10.1073/pnas.1708211114. [Epub ahead of print]


Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions.

Sinha S, Li F, Villarreal D, Shim JH, Yoon S, Myung K, Shim EY, Lee SE.

PLoS Genet. 2017 Apr 18;13(4):e1006714. doi: 10.1371/journal.pgen.1006714. eCollection 2017 Apr.


Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination.

Zan H, Tat C, Qiu Z, Taylor JR, Guerrero JA, Shen T, Casali P.

Nat Commun. 2017 Feb 8;8:14244. doi: 10.1038/ncomms14244.


DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination.

Biehs R, Steinlage M, Barton O, Juhász S, Künzel J, Spies J, Shibata A, Jeggo PA, Löbrich M.

Mol Cell. 2017 Feb 16;65(4):671-684.e5. doi: 10.1016/j.molcel.2016.12.016. Epub 2017 Jan 26.



Hromas R, Williamson E, Lee SH, Nickoloff J.

Trans Am Clin Climatol Assoc. 2016;127:176-195.


Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex.

Dutta A, Eckelmann B, Adhikari S, Ahmed KM, Sengupta S, Pandey A, Hegde PM, Tsai MS, Tainer JA, Weinfeld M, Hegde ML, Mitra S.

Nucleic Acids Res. 2017 Mar 17;45(5):2585-2599. doi: 10.1093/nar/gkw1262.


WRN regulates pathway choice between classical and alternative non-homologous end joining.

Shamanna RA, Lu H, de Freitas JK, Tian J, Croteau DL, Bohr VA.

Nat Commun. 2016 Dec 6;7:13785. doi: 10.1038/ncomms13785.


Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching.

Le MX, Haddad D, Ling AK, Li C, So CC, Chopra A, Hu R, Angulo JF, Moffat J, Martin A.

Sci Rep. 2016 Nov 17;6:37215. doi: 10.1038/srep37215.


DNA Polymerase θ: A Unique Multifunctional End-Joining Machine.

Black SJ, Kashkina E, Kent T, Pomerantz RT.

Genes (Basel). 2016 Sep 21;7(9). pii: E67. doi: 10.3390/genes7090067. Review.


Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining.

Kent T, Mateos-Gomez PA, Sfeir A, Pomerantz RT.

Elife. 2016 Jun 17;5. pii: e13740. doi: 10.7554/eLife.13740.


FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.

Kais Z, Rondinelli B, Holmes A, O'Leary C, Kozono D, D'Andrea AD, Ceccaldi R.

Cell Rep. 2016 Jun 14;15(11):2488-99. doi: 10.1016/j.celrep.2016.05.031. Epub 2016 Jun 2.


Noncanonical views of homology-directed DNA repair.

Verma P, Greenberg RA.

Genes Dev. 2016 May 15;30(10):1138-54. doi: 10.1101/gad.280545.116. Review.


The DNA resection protein CtIP promotes mammary tumorigenesis.

Reczek CR, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R.

Oncotarget. 2016 May 31;7(22):32172-83. doi: 10.18632/oncotarget.8605.


Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?

Tsai RY.

Cell Mol Life Sci. 2016 May;73(9):1803-23. doi: 10.1007/s00018-016-2152-y. Epub 2016 Feb 17. Review.


Risky business: Microhomology-mediated end joining.

Sinha S, Villarreal D, Shim EY, Lee SE.

Mutat Res. 2016 Jun;788:17-24. doi: 10.1016/j.mrfmmm.2015.12.005. Epub 2016 Jan 2. Review.


DNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiae.

Meyer D, Fu BX, Heyer WD.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6907-16. doi: 10.1073/pnas.1507833112. Epub 2015 Nov 25.


Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model.

Balestrini A, Nicolas L, Yang-Lott K, Guryanova OA, Levine RL, Bassing CH, Chaudhuri J, Petrini JH.

Mol Cancer Res. 2016 Feb;14(2):185-95. doi: 10.1158/1541-7786.MCR-15-0281. Epub 2015 Nov 4.


Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

Sfeir A, Symington LS.

Trends Biochem Sci. 2015 Nov;40(11):701-14. doi: 10.1016/j.tibs.2015.08.006. Epub 2015 Oct 1. Review.


Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells.

Khair L, Baker RE, Linehan EK, Schrader CE, Stavnezer J.

PLoS Genet. 2015 Aug 11;11(8):e1005438. doi: 10.1371/journal.pgen.1005438. eCollection 2015 Aug.

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