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Items: 1 to 20 of 88

1.

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3.

Kleinert M, Parker BL, Chaudhuri R, Fazakerley DJ, Serup A, Thomas KC, Krycer JR, Sylow L, Fritzen AM, Hoffman NJ, Jeppesen J, Schjerling P, Ruegg MA, Kiens B, James DE, Richter EA.

Mol Metab. 2016 Jun 22;5(8):646-55. doi: 10.1016/j.molmet.2016.06.007. eCollection 2016 Aug.

2.

mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1.

Moloughney JG, Kim PK, Vega-Cotto NM, Wu CC, Zhang S, Adlam M, Lynch T, Chou PC, Rabinowitz JD, Werlen G, Jacinto E.

Mol Cell. 2016 Sep 1;63(5):811-26. doi: 10.1016/j.molcel.2016.07.015. Epub 2016 Aug 25.

PMID:
27570073
3.

Altered Co-Translational Processing Plays a Role in Huntington's Pathogenesis-A Hypothesis.

Nissley DA, O'Brien EP.

Front Mol Neurosci. 2016 Jul 6;9:54. doi: 10.3389/fnmol.2016.00054. eCollection 2016.

4.

VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis.

Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T.

Mol Cell Oncol. 2014 Dec 23;1(3):e964024. doi: 10.4161/23723548.2014.964024. eCollection 2014 Jul-Sep.

5.

The small GTPases Ras and Rap1 bind to and control TORC2 activity.

Khanna A, Lotfi P, Chavan AJ, Montaño NM, Bolourani P, Weeks G, Shen Z, Briggs SP, Pots H, Van Haastert PJ, Kortholt A, Charest PG.

Sci Rep. 2016 May 13;6:25823. doi: 10.1038/srep25823.

6.

Regulation of global and specific mRNA translation by the mTOR signaling pathway.

Nandagopal N, Roux PP.

Translation (Austin). 2015 Feb 2;3(1):e983402. doi: 10.4161/21690731.2014.983402. eCollection 2015 Jan-Jun. Review.

7.

Signaling crosstalk between the mTOR complexes.

Xie J, Proud CG.

Translation (Austin). 2014 Feb 14;2(1):e28174. doi: 10.4161/trla.28174. eCollection 2014. Review.

8.

Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition.

Damerill I, Biggar KK, Abu Shehab M, Li SS, Jansson T, Gupta MB.

Mol Endocrinol. 2016 Feb;30(2):201-16. doi: 10.1210/me.2015-1194. Epub 2015 Dec 29.

PMID:
26714229
9.

Decreased PCSK9 expression in human hepatocellular carcinoma.

Bhat M, Skill N, Marcus V, Deschenes M, Tan X, Bouteaud J, Negi S, Awan Z, Aikin R, Kwan J, Amre R, Tabaries S, Hassanain M, Seidah NG, Maluccio M, Siegel P, Metrakos P.

BMC Gastroenterol. 2015 Dec 16;15:176. doi: 10.1186/s12876-015-0371-6.

10.

Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation.

Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton AC.

Biochem J. 2016 Feb 15;473(4):509-23. doi: 10.1042/BJ20151013. Epub 2015 Dec 3.

11.

Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting.

De Cicco M, Rahim MS, Dames SA.

Membranes (Basel). 2015 Sep 29;5(4):553-75. doi: 10.3390/membranes5040553. Review.

12.

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W.

Cancer Discov. 2015 Nov;5(11):1194-209. doi: 10.1158/2159-8290.CD-15-0460. Epub 2015 Aug 20.

13.

Human Dynactin-Associated Protein Transforms NIH3T3 Cells to Generate Highly Vascularized Tumors with Weak Cell-Cell Interaction.

Kunoh T, Wang W, Kobayashi H, Matsuzaki D, Togo Y, Tokuyama M, Hosoi M, Koseki K, Wada S, Nagai N, Nakamura T, Nomura S, Hasegawa M, Sasaki R, Mizukami T.

PLoS One. 2015 Aug 18;10(8):e0135836. doi: 10.1371/journal.pone.0135836. eCollection 2015.

14.

The PI3K/AKT Pathway and Renal Cell Carcinoma.

Guo H, German P, Bai S, Barnes S, Guo W, Qi X, Lou H, Liang J, Jonasch E, Mills GB, Ding Z.

J Genet Genomics. 2015 Jul 20;42(7):343-53. doi: 10.1016/j.jgg.2015.03.003. Epub 2015 Mar 19. Review.

15.

Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching.

Zhao Y, Lin Y, Zhang H, Mañas A, Tang W, Zhang Y, Wu D, Lin A, Xiang J.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9644-9. doi: 10.1073/pnas.1508647112. Epub 2015 Jul 20.

16.

Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).

Ray RM, Bavaria M, Johnson LR.

Cell Signal. 2015 Sep;27(9):1850-9. doi: 10.1016/j.cellsig.2015.06.002. Epub 2015 Jun 17.

17.

TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules.

Jevtov I, Zacharogianni M, van Oorschot MM, van Zadelhoff G, Aguilera-Gomez A, Vuillez I, Braakman I, Hafen E, Stocker H, Rabouille C.

J Cell Sci. 2015 Jul 15;128(14):2497-508. doi: 10.1242/jcs.168724. Epub 2015 Jun 8.

18.

Restoration of Normal Cerebral Oxygen Consumption with Rapamycin Treatment in a Rat Model of Autism-Tuberous Sclerosis.

Chi OZ, Wu CC, Liu X, Rah KH, Jacinto E, Weiss HR.

Neuromolecular Med. 2015 Sep;17(3):305-13. doi: 10.1007/s12017-015-8359-5. Epub 2015 Jun 6.

19.

PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation.

Yu JS, Ramasamy TS, Murphy N, Holt MK, Czapiewski R, Wei SK, Cui W.

Nat Commun. 2015 May 22;6:7212. doi: 10.1038/ncomms8212.

20.

mTOR: a pharmacologic target for autophagy regulation.

Kim YC, Guan KL.

J Clin Invest. 2015 Jan;125(1):25-32. doi: 10.1172/JCI73939. Epub 2015 Jan 2. Review.

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